Time-dependent effects of oral morphine on autotomy following brachial nerve section in the rat.

Abstract:

:In this study, the effects of morphine in drinking water on autotomy in male F344 rats having undergone brachial nerve sections were assessed during a 3-week period. Morphine was self-administered orally in tap water by the rats. Rats administered morphine just after the nerve section or 1 week after the nerve section showed a significant increase in the severity of autotomy when compared to the rats administered distilled water. Morphine had no effect on autotomy when it was administered 2 weeks after the nerve section. These results suggested that the effect of oral morphine on autotomy changes in a time-dependent manner.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Yamamoto T,Mizuguchi T

doi

10.1016/0304-3940(92)90886-c

keywords:

subject

Has Abstract

pub_date

1992-07-20 00:00:00

pages

166-8

issue

2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(92)90886-C

journal_volume

141

pub_type

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