Vasopressin and oxytocin regulation of cyclic AMP accumulation in rat hypothalamo-neurohypophysial explants in vitro.

Abstract:

:Addition of vasopressin to hypothalamo-neurohypophysial explants in vitro increased cyclic AMP accumulation whereas exogenous oxytocin decreased cyclic AMP. An opposite response pattern was observed in the neural lobe of the pituitary where vasopressin decreased and oxytocin increased cyclic AMP accumulation. Forskolin elicited a 3-fold greater increase in cyclic AMP in the neural lobe than in the supraoptic nucleus and enhanced the sensitivity of the tissues to both vasopressin and oxytocin. The ability of both vasopressin and oxytocin to modulate local cyclic AMP metabolism suggests the possibility of internal feedback within the hypothalamo-neurohypophysial system.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Meeker RB,Michels KM,Hayward JN

doi

10.1016/0304-3940(90)90076-l

subject

Has Abstract

pub_date

1990-07-03 00:00:00

pages

225-30

issue

2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(90)90076-L

journal_volume

114

pub_type

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