Abstract:
:Addition of vasopressin to hypothalamo-neurohypophysial explants in vitro increased cyclic AMP accumulation whereas exogenous oxytocin decreased cyclic AMP. An opposite response pattern was observed in the neural lobe of the pituitary where vasopressin decreased and oxytocin increased cyclic AMP accumulation. Forskolin elicited a 3-fold greater increase in cyclic AMP in the neural lobe than in the supraoptic nucleus and enhanced the sensitivity of the tissues to both vasopressin and oxytocin. The ability of both vasopressin and oxytocin to modulate local cyclic AMP metabolism suggests the possibility of internal feedback within the hypothalamo-neurohypophysial system.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Meeker RB,Michels KM,Hayward JNdoi
10.1016/0304-3940(90)90076-lsubject
Has Abstractpub_date
1990-07-03 00:00:00pages
225-30issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(90)90076-Ljournal_volume
114pub_type
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