Morphological and conduction changes in the sciatic nerve of spontaneously hypertensive rats.

Abstract:

:The morphology and function of sciatic nerve were investigated in spontaneously hypertensive rats (SHR), either control or hydralazine-treated, and in normotensive Wistar Kyoto rats of 6 months of age. In control SHR decreased percentages of class I fibers (20-15 microm in diameter), of axonal NFP-H 200 kDa neurofilament protein immunoreactivity and of nerve conduction velocity were found. The percentages of class III (10-5 microm in diameter) and IV (<5 microm in diameter) and of S100beta-immunoreactive Schwann cell profiles were increased. Treatment with the hypotensive drug hydralazine countered sciatic nerve changes. The shift of nerve composition vs. smaller fibers is probably the cause of reduced nerve conduction velocity found in SHR and is consistent with the occurrence of a sympathetic hyper innervation in this animal model of hypertension. Our findings support the hypothesis that arterial hypertension may represent a risk factor of neuropathy.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Tomassoni D,Traini E,Vitaioli L,Amenta F

doi

10.1016/j.neulet.2004.03.014

keywords:

subject

Has Abstract

pub_date

2004-05-20 00:00:00

pages

131-5

issue

2

eissn

0304-3940

issn

1872-7972

pii

S0304394004003039

journal_volume

362

pub_type

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