Somatotopic distribution of corneal afferent neurons in the guinea pig trigeminal ganglion.

Abstract:

:The size and somatotopic distribution of corneal afferent neurons in the guinea pig trigeminal ganglion were determined using a retrograde axonal tracing technique. Wheat germ agglutinin-horseradish peroxidase (WGA-HRP) was applied to the central cornea of the guinea pig and the animals were perfusion-fixed 48 h later. In addition, a preliminary study examined corneal afferent neurons in two animals latently infected with the herpes simplex virus by corneal inoculation. The majority of WGA-HRP-labelled neurons were located in the ophthalmic division of the ipsilateral ganglion. A clear dorsoventral somatotopic arrangement of labelled corneal afferent neurons was noted. The size of the neurons averaged 23 microns and the number of cells per ganglion averaged 205. By contrast, the number of labelled neurons in latently infected ganglia averaged less than 50. No size or morphological distinctions could be made between neurons from uninfected or latently infected ganglia. The results of this study have provided for the first time the precise location and somata diameter of primary afferent corneal neurons within the guinea pig trigeminal ganglion.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Keller JT,Bubel HC,Wander AH,Tierney BE

doi

10.1016/0304-3940(91)90696-q

subject

Has Abstract

pub_date

1991-01-02 00:00:00

pages

247-50

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(91)90696-Q

journal_volume

121

pub_type

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