Stria terminalis conveys a facilitatory estrogen effect on female rat lordosis reflex.

Abstract:

:The effects of bilateral cut of the stria terminalis (ST) on the dosage of estradiol benzoate (EB) needed to induce the lordosis reflex in the ovariectomized female rat were examined. Seven different doses ranging 0.5-20 micrograms were given s.c. in oil, daily for 2 days in a counterbalanced order, at 3-week intervals. The log dose-response relationship was linear in both ST-cut and sham-operated control rats. A significantly larger dose of 9.3 +/- 1.4 (mean +/- SEM) micrograms/day of EB was needed in the ST-cut rats (n = 8) to obtain a 50% lordosis quotient than in the controls (n = 7), in which a 2.0 +/- 0.3 micrograms/day dose had a similar effect. The slope of the dose-effect curve was significantly steeper in the ST-cut rats than in the controls. The ST mediates facilitatory effects of estrogen on the lordosis reflex that originate presumably in the amygdala.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Takeo T,Kudo M,Sakuma Y

doi

10.1016/0304-3940(94)11173-g

subject

Has Abstract

pub_date

1995-01-23 00:00:00

pages

79-81

issue

2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(94)11173-G

journal_volume

184

pub_type

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