Abstract:
:The effects of bilateral cut of the stria terminalis (ST) on the dosage of estradiol benzoate (EB) needed to induce the lordosis reflex in the ovariectomized female rat were examined. Seven different doses ranging 0.5-20 micrograms were given s.c. in oil, daily for 2 days in a counterbalanced order, at 3-week intervals. The log dose-response relationship was linear in both ST-cut and sham-operated control rats. A significantly larger dose of 9.3 +/- 1.4 (mean +/- SEM) micrograms/day of EB was needed in the ST-cut rats (n = 8) to obtain a 50% lordosis quotient than in the controls (n = 7), in which a 2.0 +/- 0.3 micrograms/day dose had a similar effect. The slope of the dose-effect curve was significantly steeper in the ST-cut rats than in the controls. The ST mediates facilitatory effects of estrogen on the lordosis reflex that originate presumably in the amygdala.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Takeo T,Kudo M,Sakuma Ydoi
10.1016/0304-3940(94)11173-gsubject
Has Abstractpub_date
1995-01-23 00:00:00pages
79-81issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(94)11173-Gjournal_volume
184pub_type
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journal_title:Neuroscience letters
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