Effect of TJ-960 (a Japanese herbal medicine) on free radical changes within an iron-induced focal epileptogenic region in rat brain measured by in vivo L-band electron spin resonance.

Abstract:

:In vivo L-band electron spin resonance (ESR) system was used to measure the decay of nitroxide radicals in the living rat cerebrum containing a cortical area with an iron-induced epileptogenic region. Carbamoyl-PROXYL (3-carbamoyl-2,2,5,5-tetramethyl-1-pyrrolinyloxy) was injected intraperitoneally. The decay of nitroxide radicals in the iron-injected regions at the subacute stage of epileptogenesis was prolonged. The Japanese herbal medicine, sho-saiko-to-go-keishi-ka- shakuyakuto (TJ-960), a compound known to have free radical scavenging activity, inhibited the delay of nitroxide radical decay in the rat cerebrum with an iron-induced epileptic focus following injection of carbamoyl-PROXYL. TJ-960 did not affect the decay of nitroxide radicals in the control rats' brain. These data show that TJ-960 has the scavenging activity for free radicals generated within an iron-induced epileptogenic regions of rat brain.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Komatsu M,Hiramatsu M,Yokoyama H,Willmore LJ

doi

10.1016/0304-3940(96)12412-5

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

189-92

issue

3

eissn

0304-3940

issn

1872-7972

pii

0304394096124125

journal_volume

205

pub_type

杂志文章
  • Lovastatin and mevastatin reduce basal and cytokine-stimulated production of prostaglandins from rat microglial cells in vitro: evidence for a mechanism unrelated to the inhibition of hydroxy-methyl-glutaryl CoA reductase.

    abstract::Statins were recently shown to possess anti-inflammatory activities, which might be responsible for their favourable effects in cardiovascular or CNS disorders independently from the inhibition of hydroxy-methyl-glutaryl CoA reductase. Here we investigated the effects of the statins lovastatin and mevastatin on prosta...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2003.09.066

    authors: Tringali G,Vairano M,Dello Russo C,Preziosi P,Navarra P

    更新日期:2004-01-09 00:00:00

  • Genotype combinations for monoamine oxidase-B intron 13 polymorphism and dopamine D2 receptor TaqIB polymorphism are associated with ever-smoking status among men.

    abstract::Tobacco smoke inhibits monoamine oxidase-B (MAO-B) activity in vitro and in vivo, suggesting that MAO-B inhibition is a possible contributing factor to tobacco smoke addiction. Thus, MAO-B is a possible candidate gene for predisposition to smoking. The TaqIB polymorphism for the Dopamine D2 Receptor gene (DRD2) has be...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2005.05.035

    authors: Costa-Mallen P,Costa LG,Checkoway H

    更新日期:2005-09-09 00:00:00

  • Changes in paradoxical sleep accompanying instrumental learning in the cat.

    abstract::Five animals were used as their own controls for a replication on cats of earlier findings of facilitated paradoxical sleep (PS) after learning. The experiment was based on an instrumental conditioning with positive reinforcement and three-hour recordings of the subsequent sleep. Facilitation was observed as (a) an in...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(76)90066-5

    authors: Lecas JC

    更新日期:1976-12-01 00:00:00

  • Striatal cholinergic activity during morphine-induced catalepsy in the rat: development of tolerance.

    abstract::Morphine hydrochloride (10 mg/kg,i.p.) induced marked catalepsy in rats, which was associated with significantly enhanced striatal acetylcholine levels and reduced cholinesterase activity. Rapid tolerance to morphine-induced catalepsy was noted after twice daily administrations, the tolerance being discernible after t...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(79)95355-2

    authors: Bose R,Kumar A,Bhattacharya SK

    更新日期:1979-09-01 00:00:00

  • Sex and regional differences in effects of chronic intermittent ethanol exposure on subsequent excitotoxic challenges in hippocampal slice cultures.

    abstract::The organotypic hippocampal slice culture technique was used to study how the effects of repeated ethanol withdrawal might differ between males and females at the cellular level, including potential modulation of subsequent insults. A chronic intermittent ethanol (CIE) exposure paradigm was employed, with 3 days of ex...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2013.05.011

    authors: Walls SA,Rosenwasser AM,Devaud LL

    更新日期:2013-08-29 00:00:00

  • VEGF-mediated NF-κB activation protects PC12 cells from damage induced by hypoxia.

    abstract::Neuronal apoptosis is a contributing cause of disability and death in cerebral ischemia. Nuclear factor-κB (NF-κB) may become a potential therapeutic target for hypoxic/ischemic neuron damage because NF-κB is inactivated after hypoxia exposure. Vascular endothelial growth factor (VEGF) has been found to improve neurol...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2015.10.051

    authors: Mo SJ,Hong J,Chen X,Han F,Ni Y,Zheng Y,Liu JQ,Xu L,Li Q,Yang XH,Sun RH,Yin XY

    更新日期:2016-01-01 00:00:00

  • Diffusive oxidative stress following acute spinal cord injury in guinea pigs and its inhibition by polyethylene glycol.

    abstract::Spinal cord injury (SCI) results in rapid and significant oxidative stress. We have previously demonstrated that polyethylene glycol (PEG) repairs neuronal membrane and inhibits lipid peroxidation in an in vitro model of SCI. In this study we tested the effects of PEG on oxidative stress in guinea pigs after SCI. Oxid...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2004.02.027

    authors: Luo J,Shi R

    更新日期:2004-04-15 00:00:00

  • 'Collapsed' (argyrophilic, dark) neurons in rat model of transient focal cerebral ischemia.

    abstract::To elucidate the early histopathological changes after transient focal cerebral ischemia, we made 1 h intraluminal occlusion of the middle cerebral artery on rats. After different reperfusion time, from minutes to 3 days, argyrophil III method was used for the demonstration of 'collapsed' (argyrophilic, dark) neurons....

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(93)90562-y

    authors: Czurkó A,Nishino H

    更新日期:1993-11-12 00:00:00

  • Increased adult neurogenesis in mice with a permanent overexpression of the postsynaptic 5-HT1A receptor.

    abstract::Depression is among the leading causes of disability and disease burden. Recent studies point to an involvement of altered serotonin1A receptor (5-HT1AR) -mediated adult neurogenesis in depression. However, the exact underlying mechanisms remain unclear, mainly due to the complexity of the serotonergic system with its...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2016.09.051

    authors: Noto B,Klempin F,Alenina N,Bader M,Fink H,Sander SE

    更新日期:2016-10-28 00:00:00

  • Paradoxical timing of the circadian rhythm of sleep propensity serves to consolidate sleep and wakefulness in humans.

    abstract::The contribution of the circadian pacemaker and the sleep homeostat to sleep tendency and consolidation was quantified by forced desynchrony of the sleep-wake cycle from the circadian pacemaker in eight men who lived in time-isolation for 33-36 days. Analysis of 175 polygraphically recorded sleep episodes revealed tha...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(94)90841-9

    authors: Dijk DJ,Czeisler CA

    更新日期:1994-01-17 00:00:00

  • In vivo BDNF modulation of adult functional and morphological synaptic plasticity at hippocampal mossy fibers.

    abstract::Brain-derived neurotrophic factor (BDNF) has been proposed as a key regulator and mediator of long-term synaptic modifications related to learning and memory maintenance. Our previous studies show that application of high-frequency stimulation (HFS) sufficient to elicit LTP at the dentate gyrus (DG)-CA3 pathway produc...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2008.08.069

    authors: Gómez-Palacio-Schjetnan A,Escobar ML

    更新日期:2008-11-07 00:00:00

  • Direct projections from the ventral premotor cortex to the hindlimb region of the supplementary motor area in the macaque monkey.

    abstract::A retrograde tracer, Diamidino yellow, was injected into the hindlimb region of the supplementary motor area after intracortical microstimulation mapping in the Japanese monkey. As a result, a cluster of retrogradely labeled neurons was found in the caudal bank of the arcuate sulcus, which corresponds to the ventral p...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(94)90629-7

    authors: Tokuno H,Inase M

    更新日期:1994-04-25 00:00:00

  • Morphological and conduction changes in the sciatic nerve of spontaneously hypertensive rats.

    abstract::The morphology and function of sciatic nerve were investigated in spontaneously hypertensive rats (SHR), either control or hydralazine-treated, and in normotensive Wistar Kyoto rats of 6 months of age. In control SHR decreased percentages of class I fibers (20-15 microm in diameter), of axonal NFP-H 200 kDa neurofilam...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2004.03.014

    authors: Tomassoni D,Traini E,Vitaioli L,Amenta F

    更新日期:2004-05-20 00:00:00

  • Modulatory effects of ketamine on catecholamine efflux from in vivo cardiac sympathetic nerve endings in cats.

    abstract::With the use of the microdialysis technique, we examined the modulatory effect of ketamine on catecholamine efflux from in vivo cardiac sympathetic nerve endings. A dialysis probe was implanted in the left ventricular myocardium, and dialysate norepinephrine (NE) levels in anesthetized cats were measured with liquid c...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(02)00208-2

    authors: Kitagawa H,Yamazaki T,Akiyama T,Yahagi N,Kawada T,Mori H,Sunagawa K

    更新日期:2002-05-24 00:00:00

  • Stable expression of cloned rat GABAA receptor subunits in a human kidney cell line.

    abstract::A predominant form of the GABAA/benzodiazepine receptor-Cl- channel complex is believed to consist of three different 48-55 kDa subunits (alpha, beta, gamma) with unknown stoichiometry. Plasmids containing the rat GABAA receptor cDNAs coding for alpha 1, beta 2, and gamma 2 were co-transfected, along with a plasmid en...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(93)90323-d

    authors: Hamilton BJ,Lennon DJ,Im HK,Im WB,Seeburg PH,Carter DB

    更新日期:1993-04-30 00:00:00

  • Ultrastructural demonstration of serotonin-immunoreactivity in the nervous system of an insect (Calliphora erythrocephala).

    abstract::Serotonin (5-HT) immunocytochemistry, was performed on the whole dissected nervous system of the blowfly. Employing the peroxidase-antiperoxidase technique and osmium postfixation, it was possible to examine 5-HT-immunoreactive neuronal elements first light microscopically in 25 microns sections, and, after re-embeddi...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(84)90020-x

    authors: Nässel DR,Elekes K

    更新日期:1984-07-27 00:00:00

  • Transient postnatal thyroxine treatment leads to an increased number of cholinergic neurons in the medial septum and to a higher density of cholinergic fibers in hippocampal CA3 in rats.

    abstract::Newborn male pups of Sprague-Dawley rats received daily injections of buffered L-thyroxine or saline during the first 12 days postnatally. At the age of 12 weeks, the number of immunocytochemically labeled cholinergic neuronal profiles in the medial septum/diagonal band (MS/vDB) was counted, and the density of acetylc...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(95)11997-b

    authors: Schwegler H

    更新日期:1995-10-06 00:00:00

  • Transient receptor potential protein mRNA expression in rat substantia nigra.

    abstract::Receptor gated Ca2+ entry has been associated with transient receptor potential (TRP) proteins encoded by several different genes. Here, we compare expression of mRNA for TRP isoforms encoded by genes TRP1-6 in the rat substantia nigra and whole brain. The substantia nigra and the whole brain expressed mRNA predominan...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(01)01533-6

    authors: Sylvester JB,Mwanjewe J,Grover AK

    更新日期:2001-03-09 00:00:00

  • Effect of retinoic acid and ethanol on retinoic acid receptor beta and glial fibrillary acidic protein mRNA expression in human astrocytoma cells.

    abstract::This work explores the hypothesis that perturbations caused by ethanol on the regulatory role of retinoids in brain development may be a mechanism involved in the neuropathology of fetal alcohol syndrome. The interaction of ethanol and retinoic acid (RA) on RA receptor (RAR) beta and glial fibrillary acidic protein (G...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(00)01538-x

    authors: Grummer MA,Salih ZN,Zachman RD

    更新日期:2000-11-17 00:00:00

  • APOE promoter polymorphisms and dementia in the elderly.

    abstract::Previous observations suggest a contribution of two APOE promoter polymorphisms (-219 G/T and -491 A/T) in dementia. From two independent populations of elderly (mean age of 84 and 85 years old, respectively), we observed that subjects bearing the -219T allele were at increased risk of dementia (OR = 1.9 (95% CI, 1.3-...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2004.04.063

    authors: Lambert JC,Berr C,Cottel D,Amouyel P,Helbecque N

    更新日期:2004-07-22 00:00:00

  • Involvement of alpha-adrenoceptors in norepinephrine-induced prostaglandin E2 release by rat pineal gland in vitro.

    abstract::Rat pineal glands incubated in vitro with 10 or 100 microM norepinephrine (NE) released 51% and 415% more prostaglandin E2 (PGE2) to the medium than in the absence of NE. Phentolamine (10 microM) prevented fully the effect of NE at both concentrations, whereas propranolol failed to affect it significantly. After super...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(82)90038-6

    authors: Ritta MN,Cardinali DP

    更新日期:1982-08-31 00:00:00

  • Node-like areas of intramembraneous particles in the unensheathed axons of dystrophic mice.

    abstract::The unensheathed axons in the spinal roots of adult dystrophic mice were examined by freeze-fracture electron microscopy. In most areas of these abnormal fibers the distribution of intramembraneous particles was similar to that of the internodal segments of normal axons with many more particles on the PF (internal) le...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(79)90042-9

    authors: Bray GM,Cullen MJ,Aguayo AJ,Rasminsky M

    更新日期:1979-07-01 00:00:00

  • Polymerase chain reaction quantification of lymphoid amyloid precursor protein mRNAs in Alzheimer's disease and Down's syndrome.

    abstract::Amyloid beta-protein, the major constituent of Alzheimer's disease (AD) brain amyloid deposits, is encoded by several alternatively spliced amyloid precursor protein (APP) mRNAs. The well-established associated in Down's syndrome (DS) between APP overproduction and premature development of AD, as well as the recent de...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(95)11681-l

    authors: Ledoux S,Bergeron C,Nalbantoglu J,Gauthier S,Cashman NR

    更新日期:1995-06-30 00:00:00

  • Neurocalcin immunoreactivity in rat olfactory bulb.

    abstract::Neurocalcin, a newly discovered calcium-binding protein belonging to the recoverin-like superfamily, was detected immunohistochemically in tufted cells from the rat olfactory bulb. More precisely, only periglomerular tufted cells and some tufted cells from the external plexiform layer were expressing neurocalcin. West...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(93)90285-s

    authors: Bastianelli E,Okazaki K,Hidaka H,Pochet R

    更新日期:1993-10-29 00:00:00

  • Species differences in the localization of 'peripheral' type cholecystokinin receptors in rodent brain.

    abstract::A comparison of cholecystokinin (CCK) receptor binding to sections of rat, mouse and guinea pig brain has been performed using 125I-Bolton Hunter CCK and the selective peripheral CCK receptor antagonist L-365,031. In both rat and mouse, 125I-Bolton Hunter CCK binding in the region of the interpeduncular nucleus (IPN) ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(87)90445-9

    authors: Hill DR,Shaw TM,Woodruff GN

    更新日期:1987-08-31 00:00:00

  • A GABAergic projection from the central nucleus of the amygdala to the parabrachial nucleus: an ultrastructural study of anterograde tracing in combination with post-embedding immunocytochemistry in the rat.

    abstract::To determine whether axonal terminals emanating from the central nucleus of amygdala (Ce) to the parabrachial nucleus (PBN) contain gamma-aminobutyric acid (GABA) as their neurotransmitter, an electron microscopic study was performed employing the combined techniques of WGA-HRP anterograde tracing and post-embedding i...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2005.03.013

    authors: Jia HG,Zhang GY,Wan Q

    更新日期:2005-07-01 00:00:00

  • A combinatorial approach to modulate microenvironment toward regeneration and repair after spinal cord injury in rats.

    abstract::Traumatic spinal cord injury (SCI) is a devastating condition of CNS which leads to loss of sensory as well as motor functions. Secondary damage after SCI initiates cascade of events that creates an inhibitory milieu for axonal growth and repair. Combinatorial therapies are the hope to attenuate secondary injury progr...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2020.135500

    authors: Bhattacharyya S,Dinda A,Vishnubhatla S,Anwar MF,Jain S

    更新日期:2021-01-10 00:00:00

  • Downregulation of mu-opioid receptor mRNA in the mediobasal hypothalamus of the female guinea pig following morphine treatment.

    abstract::Ribonuclease protection assays were performed on the basal hypothalamus (BH), the preoptic area (POA) and the thalamus (THAL) from female guinea pigs that were ovariectomized and implanted with morphine (n = 8) or placebo (n = 8) pellets for 1 week. An antisense [32P]rUTP labeled riboprobe, representing a 280 bp fragm...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:

    authors: Rønnekleiv OK,Bosch MA,Cunningham MJ,Wagner EJ,Grandy DK,Kelly MJ

    更新日期:1996-09-27 00:00:00

  • Robust localization and lateralization of human language function: an optimized clinical functional magnetic resonance imaging protocol.

    abstract::An optimized clinical functional magnetic resonance imaging (fMRI) protocol with a total scanning time of 8 min is presented that localizes Broca's and Wernicke's areas robustly and determines hemispheric dominance. Language function was visualized using two different sentence generation (SG) and word generation (WG) ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(03)00561-5

    authors: Stippich C,Mohammed J,Kress B,Hähnel S,Günther J,Konrad F,Sartor K

    更新日期:2003-07-31 00:00:00

  • Differential modulation of pressure pain threshold in response to transcutaneous spinal direct current stimulation with physical activity level.

    abstract::This study investigated the interaction between physical activity level and responses to transcutaneous spinal direct current stimulation (tsDCS) as reflected in changes in pressure pain threshold (PPT) in the lower extremity. Participants (n = 35, 15 males) consisted of physically active young adults. PPTs were deter...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2019.01.025

    authors: Gibson J,Tremblay F

    更新日期:2019-04-17 00:00:00