Abstract:
:In vivo L-band electron spin resonance (ESR) system was used to measure the decay of nitroxide radicals in the living rat cerebrum containing a cortical area with an iron-induced epileptogenic region. Carbamoyl-PROXYL (3-carbamoyl-2,2,5,5-tetramethyl-1-pyrrolinyloxy) was injected intraperitoneally. The decay of nitroxide radicals in the iron-injected regions at the subacute stage of epileptogenesis was prolonged. The Japanese herbal medicine, sho-saiko-to-go-keishi-ka- shakuyakuto (TJ-960), a compound known to have free radical scavenging activity, inhibited the delay of nitroxide radical decay in the rat cerebrum with an iron-induced epileptic focus following injection of carbamoyl-PROXYL. TJ-960 did not affect the decay of nitroxide radicals in the control rats' brain. These data show that TJ-960 has the scavenging activity for free radicals generated within an iron-induced epileptogenic regions of rat brain.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Komatsu M,Hiramatsu M,Yokoyama H,Willmore LJdoi
10.1016/0304-3940(96)12412-5subject
Has Abstractpub_date
1996-03-01 00:00:00pages
189-92issue
3eissn
0304-3940issn
1872-7972pii
0304394096124125journal_volume
205pub_type
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