Abstract:
:Preconditioning increases the neurons' resistance to subsequent hypoxia. An in vitro study was conducted to explore kinetic aspects of hypoxic preconditioning. Hippocampal slices were exposed to one single or repeated episodes of oxygen and glucose deprivation (OGD). The interval between OGD episodes varied between 30 min and 180 min. OGD led to a significant reduction in the population spike amplitude. Subsequent episodes of OGD did not result in a further reduction in the population spike amplitude if the interval between the episodes was ca. 60 min, which demonstrated that there were preconditioning effects. In the experiment using an interval of 30 min, population spike amplitude decreased after each OGD episode. The set-up described is useful for detecting damaging effects of OGD as well as preconditioning effects. A time window of ca. 60 min is required to induce protective mechanisms.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Brödemann R,Peters B,Höllt V,Becker Adoi
10.1016/j.neulet.2013.10.069subject
Has Abstractpub_date
2014-01-13 00:00:00pages
175-9eissn
0304-3940issn
1872-7972pii
S0304-3940(13)00983-Xjournal_volume
558pub_type
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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