Abstract:
:Immunohistochemical and biochemical investigations showed that significant protein nitration occurs in human gliomas, especially in grade IV glioblastomas at the level of astrocytes and oligodendrocytes and neurones. Enhanced alpha-tubulin immunoreactivity was co-present in the same elements in the glioblastomas. Proteomic methodologies were employed to identify a nitrated protein band at 55 kDa as alpha-tubulin. Peptide mass fingerprinting procedures demonstrated that tubulin is nitrated at Tyr224 in grade IV tumour samples but is unmodified in grade I samples and in non-cancerous brain tissue. These results provide the first characterisation of endogenously nitrated tubulin from human tumour samples.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Fiore G,Di Cristo C,Monti G,Amoresano A,Columbano L,Pucci P,Cioffi FA,Di Cosmo A,Palumbo A,d'Ischia Mdoi
10.1016/j.neulet.2005.10.011keywords:
subject
Has Abstractpub_date
2006-02-06 00:00:00pages
57-62issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(05)01161-4journal_volume
394pub_type
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