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The role of Period1 in non-photic resetting of the hamster circadian pacemaker in the suprachiasmatic nucleus.

Abstract：

:Non-photic stimuli, such as diurnal wheel running in rodents, phase shift the circadian clock and suppress the expression of Per1 in the suprachiasmatic nucleus (SCN). The goal of the present study was to directly decrease Per1 expression using antisense (AS) oligodeoxynucleotides to determine if such suppression produced non-photic phase shifts. Injections of Per1-AS suppressed expression of Per1 within the SCN and produced phase shifts similar to those resulting from other non-photic manipulation, with large phase advances to injections during the subjective day. These results indicate that the decrease in expression of Per1 is a cause rather than a consequence of non-photic phase shifts.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Hamada T,Antle MC,Silver R

doi

10.1016/j.neulet.2004.02.061

keywords:

subject

Has Abstract

pub_date

2004-05-20 00:00:00

pages

87-90

issue

2

eissn

0304-3940

issn

1872-7972

pii

S030439400400268X

journal_volume

362

pub_type

杂志文章

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