Abstract:
:Using retrograde transport of Fluoro-Gold (FG) combined with immunofluorescence for phenylethanolamine-N-methyltransferase (PNMT), we have examined afferents to the nucleus locus coeruleus (LC) from the rostral ventrolateral medulla (nucleus paragigantocellularis; PGi) in rats sustaining lesions of the medullary adrenergic bundle (MB). In lesioned rats, very few adrenergic LC-projecting neurons persist in the PGi ipsilateral to the lesion, representing a 90% decrease in comparison to non-lesioned animals. These results indicate that almost all adrenergic input to the LC from C1 neurons in PGi is conveyed by the MB. In contrast, the number of non-adrenergic LC afferent neurons in the PGi ipsilateral to the lesion only decreased by 48% after such lesions. Thus, this pathway also provides non-adrenergic projections to LC from PGi, but many of these are conveyed by other route(s) as well.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Astier B,Van Bockstaele EJ,Aston-Jones G,Pieribone VAdoi
10.1016/0304-3940(90)90612-dsubject
Has Abstractpub_date
1990-10-16 00:00:00pages
141-6issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(90)90612-Djournal_volume
118pub_type
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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更新日期:2007-04-18 00:00:00
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