Anatomical evidence for multiple pathways leading from the rostral ventrolateral medulla (nucleus paragigantocellularis) to the locus coeruleus in rat.

Abstract:

:Using retrograde transport of Fluoro-Gold (FG) combined with immunofluorescence for phenylethanolamine-N-methyltransferase (PNMT), we have examined afferents to the nucleus locus coeruleus (LC) from the rostral ventrolateral medulla (nucleus paragigantocellularis; PGi) in rats sustaining lesions of the medullary adrenergic bundle (MB). In lesioned rats, very few adrenergic LC-projecting neurons persist in the PGi ipsilateral to the lesion, representing a 90% decrease in comparison to non-lesioned animals. These results indicate that almost all adrenergic input to the LC from C1 neurons in PGi is conveyed by the MB. In contrast, the number of non-adrenergic LC afferent neurons in the PGi ipsilateral to the lesion only decreased by 48% after such lesions. Thus, this pathway also provides non-adrenergic projections to LC from PGi, but many of these are conveyed by other route(s) as well.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Astier B,Van Bockstaele EJ,Aston-Jones G,Pieribone VA

doi

10.1016/0304-3940(90)90612-d

subject

Has Abstract

pub_date

1990-10-16 00:00:00

pages

141-6

issue

2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(90)90612-D

journal_volume

118

pub_type

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