Neonatal transection of the corpus callosum affects paw preference lateralization of adult Swiss mice.

Abstract:

:In the present work, the hypothesis that the ontogenetic development of the corpus callosum (CC) affects the establishment of behavioral lateralization was tested by studying paw preference performance in adult Swiss mice that were subjected to mid-sagittal transection of the CC on the first postnatal day. Magnitude and direction of laterality were evaluated independently. No significant differences between groups were found for the magnitude of paw preference. On the other hand, the transected group presented a significant populational bias favoring the left paw that was not present in the control groups. These results lend support to the hypothesis that the development of the CC plays a role in the establishment of the normal pattern of behavioral lateralization.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Manhães AC,Krahe TE,Caparelli-Dáquer E,Ribeiro-Carvalho A,Schmidt SL,Filgueiras CC

doi

10.1016/s0304-3940(03)00746-8

keywords:

subject

Has Abstract

pub_date

2003-09-11 00:00:00

pages

69-72

issue

2

eissn

0304-3940

issn

1872-7972

pii

S0304394003007468

journal_volume

348

pub_type

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