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Association between dopamine D4 receptor (DRD4) exon III polymorphism and Neuroticism in the Japanese population.

Abstract：

:The association between the dopamine D4 receptor (DRD4) exon III polymorphism and personality trait of novelty seeking (NS) has been studied intensively. In the Japanese population, the results of the previous studies did not always coincide. In the present study, we investigated the association between the polymorphism and personality traits evaluated by using the Revised NEO Personality Inventory (NEO PI-R) and State-Trait Anxiety Inventory (STAI) in 196 Japanese subjects. A meta-analysis of the present and previous Japanese studies was also conducted regarding NS. As a result, significant association was observed between the polymorphism and personality traits evaluated by using NEO PI-R as a whole (p=0.022, MANCOVA). Subsequent analyses showed a significant association between short alleles (2-4 repeats) and higher scores for Neuroticism or its subscales, Anxiety, Depression, and Vulnerability (p=0.015, 0.039, 0.021, and 0.008, respectively, uncorrected). No other significant difference in the scores for NEO PI-R was observed in the subsequent analyses. Significant association was also observed between the polymorphism and scores for STAI as a whole (p=0.004, MANCOVA). Subsequent analyses did not show significant association, although a weak trend for the relation between the genotype consisting of short alleles and Trait Anxiety was observed (p=0.10, uncorrected). The meta-analysis showed no significant association between the polymorphism and NS. Thus, the present study suggested the association between the short allele of the DRD4 exon III polymorphism and personality trait of Neuroticism in Japanese subjects.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Tochigi M,Hibino H,Otowa T,Kato C,Marui T,Ohtani T,Umekage T,Kato N,Sasaki T

doi

10.1016/j.neulet.2006.01.020

keywords:

subject

Has Abstract

pub_date

2006-05-08 00:00:00

pages

333-6

issue

3

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(06)00047-4

journal_volume

398

pub_type

杂志文章,meta分析

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