Inhibition of GABA and benzodiazepine receptor binding by penicillins.

Abstract:

:Penicillins are thought to be GABA receptor antagonists. In order to determine the affinities of various penicillin derivatives for the GABA receptor, their potencies as inhibitors of specific [3H]GABA binding to rat brain membranes were investigated. All investigated penicillins inhibit specific [3H]GABA binding, with IC50 values ranging from 2 to 60 mM. The results are consistent with the assumption that penicillins are weak GABA receptor antagonists.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Antoniadis A,Müller WE,Wollert U

doi

10.1016/0304-3940(80)90302-x

subject

Has Abstract

pub_date

1980-07-01 00:00:00

pages

309-12

issue

3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(80)90302-X

journal_volume

18

pub_type

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