Abstract:
:Metamorphosis in the fly (Musca domestica) involves extensive lysis, neurogenesis and reorganization of neural tissue. Despite this, two experiments are reported which show aspects of larval memory persist into the adult form. Experimental larvae were reared in sawdust scented with aversive odours (mint or geraniol). Control larvae were reared on plain sawdust. In blind post-metamorphosis testing using a Y maze, adult flies showed a preference for the specific odour to which the larvae had been exposed. Control flies found both test odours aversive. A second experiment explores the possible role of cell survival through metamorphosis as a mechanism of the persistence of memory. Cells from trained donor flies when grafted into untrained recipients produced specific changes in recipient odour preference reflecting the donor larvae training.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ray Sdoi
10.1016/s0304-3940(98)00892-1keywords:
subject
Has Abstractpub_date
1999-01-04 00:00:00pages
37-40issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(98)00892-1journal_volume
259pub_type
杂志文章abstract::The vanilloid receptor-1 (TRPV1), expressed by nociceptive fibers, is a transducer of thermal and chemical nociceptive messages. However, endogenous ligands excite TRPV1 receptors localized on central nociceptive terminals and interneurons. Using immunocytochemistry at the ultrastructural level, we show that TRPV1 is ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2003.12.051
更新日期:2004-03-04 00:00:00
abstract::The hypothesis that synaptic transmission between the auditory nerve and the cochlear nucleus is mediated by an excitatory amino acid acting through N-methyl-D-aspartate (NMDA) receptors was examined in an in vitro preparation of the chicken brainstem. The ability of various bath-applied excitatory amino acid receptor...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(83)90089-7
更新日期:1983-09-19 00:00:00
abstract::Using renal arteries from young (6 months), mature (18 months) and old (70 months) rabbits, the effect of dopamine on 3',5'-cyclic adenosine monophosphate (cAMP) generation was studied. No significant differences in basal adenylate cyclase values were found in homogenates of renal artery from young, mature or old rabb...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(84)90394-x
更新日期:1984-10-26 00:00:00
abstract::The involvement of protein kinases A and C in the induction of low frequency stimulation-induced long-term depression (LTD) in the medial perforant path of the dentate gyrus in vitro has been studied using the selective PKA inhibitors H-89 and KT 5720 and PKC inhibitors Bisindolylmaleimide and Ro-31-8220. The PKC inhi...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(99)00561-3
更新日期:1999-10-22 00:00:00
abstract::Cerebral ischemia/reperfusion involves inflammatory process and naloxone is able to reduce infarct volume and has been used as a therapeutic agent for brain injury. Hypoxia induces the immediate early genes (IEGs) rapidly and transiently that may initiate a cascade of cellular responses that are necessary for survival...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.04.036
更新日期:2008-06-20 00:00:00
abstract:INTRODUCTION:Several lines of evidence support an immunologic involvement in obsessive-compulsive disorder (OCD): the increased prevalence of OCD in patients with rheumatic fever (RF), and the aggregation of obsessive-compulsive spectrum disorders among relatives of RF probands. Tumor necrosis factor alpha is a proinfl...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.07.022
更新日期:2008-09-12 00:00:00
abstract::Two opposing hypotheses on the homology of the avian brain suggest that the dorsal ventricular ridge of birds is comparable in certain respects either to the neocortex or to the claustroamygdalar complex of mammals. To help resolve this issue, we examined in adult chicken brains the gene expression of RORβ mRNA, a sel...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2012.05.068
更新日期:2012-07-19 00:00:00
abstract::A cDNA clone encoding a novel protein (Cer-1) was isolated from a mouse cerebellar cDNA library. The deduced amino acid sequence of Cer-1 is not homologous to other sequences in the protein sequence data base. RNA blot analysis suggests that expression of Cer-1 RNA occurs selectively in the adult cerebellum and in pur...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(96)12628-8
更新日期:1996-05-10 00:00:00
abstract::Intracellular recordings were made from primary sensory hair cells located on the dorsal side of the anterior crista segment of the squid statocyst. These hair cells were electrophysiologically identified by the occurrence of an antidromic action potential after electrical stimulation of the crista nerve. Two types of...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(93)90300-a
更新日期:1993-10-29 00:00:00
abstract::Vasopressin (VP) is a peptide consisting of 9 amino acids which acts as a neurotransmitter or neuromodulator in the central nervous system. Neurons containing VP project to some nuclei in the hypothalamus that have a role in energy metabolism. To clarify the possible role of VP on glucose metabolism in the brain, we e...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(95)11536-6
更新日期:1995-05-12 00:00:00
abstract::Fluorescent tracers (Nuclear Yellow, True Blue, Fast Blue) were injected, in various combinations, into the globus pallidus and substantia nigra in three marmosets. Examination of perikarya in the ipsilateral neostriatum, well removed from pallidal injection sites, revealed that the predominant pattern was of single-l...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(84)90127-7
更新日期:1984-08-24 00:00:00
abstract::Recordings from the intact nervus terminalis with a hook electrode or from a stump of the divided nerve with a suction electrode show a tonic, irregular discharge of broad, low frequency spikes in ca. 4-6 units. These nerve impulses are efferent from the brain. The mean frequency of discharge is not influenced by vari...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(84)90074-0
更新日期:1984-02-10 00:00:00
abstract::The major human neurodegenerative diseases are characterised by ubiquitin-positive intraneuronal inclusions, however the precise nature of the ubiquitin modifications in these structures is unclear. Using a monoclonal antibody specific for Lys63-linked polyubiquitin we have performed the first immunohistochemical anal...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2009.05.074
更新日期:2009-09-04 00:00:00
abstract::It is well established that neurons in the dorsal medulla, including the area postrema and the medial nucleus tractus solitarius (mNTS), are involved in the central actions of circulating peptides such as angiotensin II (ANG II) and arginine vasopressin (AVP). This report describes a preparation that permits the ident...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(93)90001-2
更新日期:1993-03-19 00:00:00
abstract::Chronological changes of dopamine D1 receptor binding were determined in the strionigral system of the rat brain by using [3H]SCH 23390, a highly selective dopamine D1 antagonist, in vitro autoradiography after 90 min of right middle cerebral artery (MCA) occlusion and after such occlusion followed by different period...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(92)90533-d
更新日期:1992-01-06 00:00:00
abstract::Hyperactivity of the hypothalamic-pituitary-adrenal axis is associated with depression. We investigated the effect of various types of antidepressant agents in vitro on the function of glucocorticoid receptor (GR). Desipramine, clomiplamine, fluoxetine, milnacipran and clorgyline all induced rapid and sustained transl...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(03)00261-1
更新日期:2003-05-22 00:00:00
abstract::Hypoxic-ischemic brain damage (HIBD) leads to acute death and chronic neurological dysfunction in neonates. To date, there is no satisfactory acknowledged strategy to provide neuroprotection completely. Verbascoside (VB) has been proved to possess antioxidative, anti aging and neuroprotective activities. The aim of th...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2019.134415
更新日期:2019-10-15 00:00:00
abstract::The streptozotocin (STZ)-induced diabetes model is widely used for the induction of neuropathy in the rat. In this model, diabetic animals often display chronic illness, which raises objections not only on ethical but also on scientific grounds. In this study, the investigators set out to determine the impact of bodyw...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.02.051
更新日期:2008-05-02 00:00:00
abstract::We investigated the effects of a representative anti-epileptic or anti-psychotic drug, carbamazepine (CBZ), on the induction of long-term potentiation (LTP) in the perforant path-dentate gyrus pathway in 15 chronically prepared rabbits. Pharmacokinetically injected low-dose CBZ, which produced steady serum levels of 2...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)90266-6
更新日期:1994-03-28 00:00:00
abstract::Pargyline, an inhibitor of monoamine oxidase (MAO), prevented 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced inhibition of dihydroxyphenylalanine (DOPA) production by tyrosine hydroxylase (TH) system in rat striatal tissue slices. The result suggests that the metabolism of MPTP in rat striatal tissue slic...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(85)90509-9
更新日期:1985-06-24 00:00:00
abstract::We studied the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) on seizure susceptibility in rats. rTMS of 1000 pulses at 0.5 Hz led to a prolonged latency for seizure development after an intraperitoneal injection of pentylenetetrazol. The rTMS effectively prevented the development of stat...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(01)02116-4
更新日期:2001-09-14 00:00:00
abstract::The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene has been reported to be a candidate gene for susceptibility to Parkinson's disease (PD), but results of different studies are conflicting. Here, we conducted a meta-analysis of published case-control studies to evaluate the association between MTHFR C677T and A...
journal_title:Neuroscience letters
pub_type: 杂志文章,meta分析
doi:10.1016/j.neulet.2017.10.060
更新日期:2018-01-01 00:00:00
abstract::The diagonal band of Broca (DBB) is involved in cardiovascular control in rats. In the present study, we report the effect of acute and reversible neurotransmission inhibition in the DBB by bilateral microinjection of the nonselective neurotransmission blocker CoCl(2) (1mM, 100 nL) on the cardiac baroreflex response i...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.10.055
更新日期:2008-12-26 00:00:00
abstract::We recently showed that the RNA regulator, HuR, is translocated to the cytoplasm in astrocytes in the acute phase of spinal cord injury (SCI), consistent with its activation. HuR positively modulates expression of many pro-inflammatory factors, including IL-1β, TNF-α, and MMP-12, which are present at high levels in th...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2017.05.003
更新日期:2017-06-09 00:00:00
abstract::Intracellular recording techniques were used to monitor the evoked responses in hippocampal CA1 pyramidal cells following focal stimulation of the proximally and distally located apical dendritic synapses. The local anaesthetic, QX-314, when injected into individual cells, caused a complete time-dependent blockade of ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)90665-3
更新日期:1994-05-19 00:00:00
abstract::We examined effects of centrally administered capsaicin on sympathetic nerve activity (SNA), blood pressure (BP) and heart rate (HR) in chloralose anesthetized cats (n = 18). Upon perfusion of the lower brain stem via the left vertebral artery, capsaicin (0.1-1.0 microM) caused dose-dependent increases in preganglioni...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(97)00280-2
更新日期:1997-05-02 00:00:00
abstract::The cerebrospinal fluid (CSF)/serum albumin ratio has been used a marker for blood CSF barrier permeability in 116 normal patients. We attempted to correlate the CSF/serum albumin ratio with a number of clinically measurable parameters including alcohol consumption. Alcohol consumption had a significant effect on the ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(87)90700-2
更新日期:1987-08-18 00:00:00
abstract::Decreased expression of NT-3 mRNA in the sciatic nerve and leg muscles of streptozotocin (STZ)-diabetic rats has been associated with the pathogenesis of diabetic neuropathy. The aim of this study was to determine whether STZ-induced diabetes also affects the expression of NT-3 mRNA in the central and peripheral proje...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(99)00124-x
更新日期:1999-03-26 00:00:00
abstract::We present results of homozygosity mapping in two siblings affected with early onset Parkinson's disease (EOPD) and mutation screening of ATP13A2 in these and other Iranian EOPD patients. Genome-wide SNP homozygosity analysis revealed linkage to a locus that included ATP13A2, and sequencing of the gene revealed a nove...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2014.06.023
更新日期:2014-08-08 00:00:00
abstract::Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) may involve many target organs with relevant variability among affected individuals. We performed a multi-organ assessment tapping nervous system, skeletal muscle and cardiovascular system in thirty-nine individuals be...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2011.10.062
更新日期:2012-01-06 00:00:00