Effect of naloxone on the induction of immediately early genes following oxygen- and glucose-deprivation in PC12 cells.

abstract：:Aging is associated with cognitive deterioration. A recent study showed two polymorphisms (rs505058 in LMNA and rs11622883 near a SERPINA13 gene), identified in a genome-wide association study of late-onset Alzheimer's disease, to be associated with cognitive function (Mini Mental State Examination) in a UK elderly po...

journal_title：Neuroscience letters

authors： Yeh HL,Hou SJ,Yen FC,Hong CJ,Liou YJ,Yang AC,Liu ME,Tsai SJ

更新日期：2011-10-17 00:00:00

abstract：:Protein synthesis is required for long-lasting synaptic plasticity. We examined the time-dependent changes in protein expression that occurred in the hippocampus during synaptic plasticity using two-dimensional gel electrophoresis followed by mass spectrometry. The levels of 15 proteins were significantly changed in m...

journal_title：Neuroscience letters

authors： Matsuura K,Nakamura-Hirota T,Takano M,Otani M,Kadoyama K,Matsuyama S

更新日期：2013-10-25 00:00:00

abstract：:MicroRNAs (miRs) are endogenous small RNAs that regulate gene expression at the post-transcriptional level by mediating mRNA degradation or transcriptional inhibition. MiRs were implicated in the pathogenesis of numerous neurodegenerative diseases, including Parkinson's disease (PD). In this study we analyzed the poss...

journal_title：Neuroscience letters

authors： Lungu G,Stoica G,Ambrus A

更新日期：2013-10-11 00:00:00

abstract：:Oxytocin (OT) modulation of synaptic transmission between olfactory bulb neurones has been implicated in the induction of maternal behaviour, but the mechanism of action is unknown. We examined the action of OT on gamma-aminobutyric acid(A) (GABA(A)) receptor-mediated spontaneous inhibitory postsynaptic currents (sIPS...

journal_title：Neuroscience letters

authors： Osako Y,Otsuka T,Taniguchi M,Oka T,Kaba H

更新日期：2000-07-28 00:00:00

abstract：:Post-stroke 'pushing' behaviour appears to be caused by impaired perception of vertical in the roll plane. While pushing behaviour typically resolves with stroke recovery, it is not known if misperception of vertical persists. The purpose of this study was to determine if perception of vertical is impaired amongst str...

journal_title：Neuroscience letters

authors： Mansfield A,Fraser L,Rajachandrakumar R,Danells CJ,Knorr S,Campos J

更新日期：2015-03-17 00:00:00

abstract：:Total RNA was purified from rat forebrain at different postnatal ages and analyzed by Northern blot using a specific neurotensin receptor RNA probe. The rat neurotensin receptor mRNA was present in high amount during the first 10 days of life. Thereafter, it rapidly decreased and was undetected after 20 days. [3H]neur...

journal_title：Neuroscience letters

authors： Hermans E,Jeanjean AP,Laduron PM,Octave JN,Maloteaux JM

更新日期：1993-07-09 00:00:00

abstract：:Basal forebrain (BF) lesions induced by ibotenic acid produced increases in the Bmax and Kd values of [3H]QNB binding sites in the frontal cortex, parietal cortex, and hippocampus. Twenty-eight-day successive administration of propentofylline (10 and 25 mg/kg, p.o.) significantly reduced the Kd values of [3H]QNB bindi...

journal_title：Neuroscience letters

authors： Fuji K,Hiramatsu M,Hayashi S,Kameyama T,Nabeshima T

更新日期：1993-02-05 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) immunoreactive afferent nerves were seen intrarenally by prenatal day 16. They grow rapidly and CGRP positive nerves are observed at birth associated with the arterial and venous vascular tree, forming a rich plexus in the pelvic region and in the connective tissue located near t...

journal_title：Neuroscience letters

authors： Barajas L,Liu L,Nishiyama C

更新日期：1991-12-09 00:00:00

abstract：:Reflex micturition was evoked in both non-immobilized (n = 5) and immobilized (n = 5) decerebrate cats by filling the bladder with physiological saline. Intracellular recordings were made from pudendal motoneurons (PU-MNs; n = 14) throughout the periods of before, during and after reflex micturition. The changes in th...

journal_title：Neuroscience letters

authors： Shimoda N,Takakusaki K,Nishizawa O,Tsuchida S,Mori S

更新日期：1992-02-03 00:00:00

abstract：:Using in vivo voltammetric detection of nitric oxide (NO) a previous study demonstrated an increased NO release at the lumbar dorsal horn level of the spinal cord by peripheral inflammatory processes in decerebrated-spinalized rats. This study concerns the effects of acute peripheral stimulations. Gentle non-noxious o...

journal_title：Neuroscience letters

authors： Rivot JP,Montagne-Clavel J,Besson JM

更新日期：2002-03-01 00:00:00

abstract：:The distribution of neurons containing the messenger RNA encoding preprotachykinin, the precursor of the neuropeptides substance P and K, was examined in the striatum of the rat. The large majority of cells densely labelled by in situ hybridization histochemistry (using a 35S-radiolabelled RNA probe complementary of t...

journal_title：Neuroscience letters

authors： Chesselet MF,Robbins E

更新日期：1989-01-02 00:00:00

abstract：:The perinatal period of brain is characterized by dynamic changes in structure and high propensity for epilepsy. Animal models have shown that alterations of AMPA receptor (AMPAR) assembly or function may be related to seizure-induced cell damage, long-lasting impairments in brain development and seizure threshold. Ho...

journal_title：Neuroscience letters

authors： Jiang Q,Wang J,Wu Y,Wu X,Qin J,Jiang Y

更新日期：2008-10-17 00:00:00

abstract：:Although a neural component has been suggested to contribute to the energetic cost of muscle contraction in vivo, the association between neural and energetic factors has not been determined during voluntary contractions in humans. Twenty young (24±1years, 10 women) healthy individuals performed isometric ankle dorsif...

journal_title：Neuroscience letters

authors： Christie AD,Foulis SA,Kent JA

更新日期：2016-08-26 00:00:00

abstract：:Neural stem cells (NSCs) are pluripotent cells capable of differentiation into dopaminergic (DA) neurons, which are the major cell types damaged in Parkinson's disease (PD). Therefore, NSCs are considered the most promising cell source for cell replacement therapy of PD. However, the poor differentiation and maturatio...

journal_title：Neuroscience letters

authors： Tan X,Zhang L,Zhu H,Qin J,Tian M,Dong C,Li H,Jin G

更新日期：2014-06-13 00:00:00

abstract：:The reversible specific binding of [3H]diazepam was observed by a radioligand method in homogenates of cultured cells of mouse glioblastoma. It was characterized by an equilibrium dissociation constant Kd = 91 +/- 5 nM and the number of maximal binding sites (Bmax) of 1006 +/- 100 fmol/mg protein. The half-saturation ...

journal_title：Neuroscience letters

authors： Zlobina GP,Kondakova LI,Khalansky AS

更新日期：1984-12-21 00:00:00

abstract：:Several constituents of chromaffin granules were quantitatively determined in noradrenaline and adrenaline cells purified from bovine adrenal medulla. As far as secretory peptides are concerned noradrenaline granules contained slightly more secretogranin II, but much less chromogranin A than adrenaline granules. This ...

journal_title：Neuroscience letters

authors： Weiss C,Cahill AL,Laslop A,Fischer-Colbrie R,Perlman RL,Winkler H

更新日期：1996-06-14 00:00:00

abstract：:One of the clinical characteristics of psychogenic tremors (PT) is the disruption or transient cessation of tremor with distractive manoeuvres, including those involving the performance of voluntary movements with the contralateral hand. Seven patients with PT, 11 patients with Parkinson's disease (PD), 10 patients wi...

journal_title：Neuroscience letters

authors： Kumru H,Valls-Solé J,Valldeoriola F,Marti MJ,Sanegre MT,Tolosa E

更新日期：2004-11-11 00:00:00

abstract：:The potassium conductance (gK) blockers tetraethylammonium (TEA) and 4-aminopyridine (4-AP) strongly excited experimental neuromas that had spontaneous discharge, but had minimal effects on acutely cut nerves and on old, quiescent neuromas. Resting gK apparently moderates hyperexcitability in active neuromas. ...

journal_title：Neuroscience letters

authors： Devor M

更新日期：1983-09-30 00:00:00

abstract：:This study assessed whether the use of an "anchor system" benefited older adults who performed a tandem walking task. Additionally, we tested the effects of practice with the anchor system during walking on trunk stability, in the frontal plane, of older adults. Forty-four older adults were randomly assigned to three ...

journal_title：Neuroscience letters

authors： Costa AA,Manciopi PA,Mauerberg-deCastro E,Moraes R

更新日期：2015-11-16 00:00:00

abstract：:Plasma renin activity (PRA) was determined in plasma samples obtained approximately at 6-min intervals during consecutive non-rapid eye movement sleep (NREMS) and rapid eye movement sleep (REMS) periods in rats chronically implanted with EEG electrodes, a brain thermistor, and an intracardiac catheter. PRA was low in ...

journal_title：Neuroscience letters

authors： Obál F Jr,Beranek L,Brandenberger G

更新日期：1994-09-26 00:00:00

abstract：:Prostaglandins (PGs) were measured in perfusate from the lumbar intrathecal (IT) space of pentobarbital anaesthetized rats. The level of PGE2, but not of PGF2 alpha or 6-keto PGF1 alpha, was increased by immersion of a hindpaw in water at a noxious temperature (50 degrees C). No increase in PGE2 was produced by non-no...

journal_title：Neuroscience letters

authors： Coderre TJ,Gonzales R,Goldyne ME,West J,Levine JD

更新日期：1990-07-31 00:00:00

abstract：:Five monoclonal antibodies specific for rat monocytes/macrophages were used to characterize macrophages/microglia bulk isolated from neonatal and adult rat brain. The majority of brain macrophages was positive for all antibodies tested with minor differences between cultures derived from developing and mature central ...

journal_title：Neuroscience letters

authors： Graeber MB,Banati RB,Streit WJ,Kreutzberg GW

更新日期：1989-09-11 00:00:00

abstract：:A non-calcium-dependent chloride channel of conductance 62 pS, found in isolated inside-out patches of cultured fetal rat hippocampal neurons, is described. The channel does not require the presence of any neurotransmitter to be active and probably plays a part in maintaining the normal resting membrane potential. ...

journal_title：Neuroscience letters

authors： Shukla H,Pockett S

更新日期：1990-05-04 00:00:00

abstract：:Cholecystokinin octapeptide (CCK-8) is the most potent endogenous anti-opioid peptide and regulates a variety of physiological processes. In our previous study, we found that exogenous CCK-8 attenuated naloxone-induced withdrawal symptoms, but the possible regulative effects of CCK-8 on the rewarding effects of morphi...

journal_title：Neuroscience letters

authors： Wen D,Cong B,Ma C,Yang S,Yu H,Ni Z,Li S

更新日期：2012-02-21 00:00:00

abstract：:Parvalbumin-immunoreactive dystrophic neurites and aberrant terminal sprouts associated with senile plaques, together with preserved density of parvalbumin-immunoreactive neurons, were found in the cerebral cortex of two patients with Alzheimer's disease, one of them familiar, in which a biopsy of the left frontal lob...

journal_title：Neuroscience letters

authors： Ferrer I,Zújar MJ,Rivera R,Soria M,Vidal A,Casas R

更新日期：1993-08-20 00:00:00

abstract：:Vanilloid receptors are activated by capsaicin, the pungent ingredient in hot pepper. They are also specifically and competitively inhibited by capsazepine (CPZ). To determine whether CPZ is specific to vanilloid receptors, its effects were tested on the currents evoked by nicotine in rat trigeminal ganglia. We found ...

journal_title：Neuroscience letters

authors： Liu L,Simon SA

更新日期：1997-05-30 00:00:00

abstract：:The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene has been reported to be a candidate gene for susceptibility to Parkinson's disease (PD), but results of different studies are conflicting. Here, we conducted a meta-analysis of published case-control studies to evaluate the association between MTHFR C677T and A...

journal_title：Neuroscience letters

authors： Liu L,Zhang L,Guo L,Yu Q,Li H,Teng J,Xie A

更新日期：2018-01-01 00:00:00

abstract：:A new modification of the nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase reaction was used to study the distribution of a specific subset of neurons in rat striatum. These neurons are known to also contain somatostatin-like immunoreactivity (SLI). We have previously found a heterogeneous distribution o...

journal_title：Neuroscience letters

authors： Kowall NW,Beal MF,Ferrante RJ,Martin JB

更新日期：1985-08-16 00:00:00

abstract：:An approximately 54-kDa protein that has binding sites for the competitive N-methyl-D-aspartate (NMDA) receptor antagonists 3-((+-)-2-carboxypiperazine-4-yl)-propyl-1-phosphonic acid (CPP) and (+-)-(E)-2-amino-4-propyl-5-phosphonopentenoic acid (CGP 39653) was purified from rat brain synaptic membranes. Polyclonal ant...

journal_title：Neuroscience letters

authors： Eggeman KT,Pal R,Walsh J,Kumar KN,Michaelis EK

更新日期：1993-08-20 00:00:00

abstract：:Aquaporin-1 (AQP1) is a water channel expressed in the choroid plexus and participates in forming cerebrospinal fluid. Interestingly, reactive astrocytes also express AQP1 in the central nervous system under some pathological conditions. On the other hand, 3-nitropropionic acid (3NP) is a mitochondrial toxin that caus...

journal_title：Neuroscience letters

authors： Hoshi A,Tsunoda A,Yamamoto T,Tada M,Kakita A,Ugawa Y

更新日期：2016-07-28 00:00:00