Abstract:
:Several constituents of chromaffin granules were quantitatively determined in noradrenaline and adrenaline cells purified from bovine adrenal medulla. As far as secretory peptides are concerned noradrenaline granules contained slightly more secretogranin II, but much less chromogranin A than adrenaline granules. This can be explained by the dependence of the biosynthesis of chromogranin A on corticosteroids. Proteolytic processing of chromogranin A and secretogranin II was higher in noradrenaline cells which was paralleled by a higher content of the prohormone convertase PC2. Noradrenaline granules also contained a higher concentration of the vesicular monoamine transporter (vMAT2). No differences were found for dopamine beta-hydroxylase, prohormone convertase PC1, carboxypeptidase H and synaptophysin. These results indicate that the secretory cocktail of peptides released from these cells differs significantly between adrenaline and noradrenaline storing cells.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Weiss C,Cahill AL,Laslop A,Fischer-Colbrie R,Perlman RL,Winkler Hdoi
10.1016/0304-3940(96)12712-9subject
Has Abstractpub_date
1996-06-14 00:00:00pages
29-32issue
1eissn
0304-3940issn
1872-7972pii
0304394096127129journal_volume
211pub_type
杂志文章abstract::The role of 5-HTTLPR and 5-HT2C Cys23Ser polymorphisms in the psychopathology of mood disorders and suicide behavior is controversial. The aim of present study was to investigate the association between 5-HTTLPR and 5-HT2C Cys23Ser variants and susceptibility to bipolar I disorder (BID). The 5-HT2C genotypes were stud...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2015.01.027
更新日期:2015-03-17 00:00:00
abstract::We measured levels of basal and norepinephrine (NE) -induced melatonin release in cultured pineal bodies of rats just after and 2 days after irradiation (20 or 200 Gy) or sham-irradiation. On the day of irradiation, basal and NE-induced melatonin release were not affected by irradiation. Two days after irradiation, ba...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(00)00984-8
更新日期:2000-04-21 00:00:00
abstract::The neurotransmitter gamma-aminobuteric acid (GABA) is believed to have a controlling action on spinal locomotor networks. In spasticity, spinal locomotor networks are thought to play a role. A well known drug in the treatment of spasticity is the GABA(B) agonist Baclofen. We report an inhibitory effect of Baclofen on...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(01)02404-1
更新日期:2002-03-15 00:00:00
abstract::The aim of this study was to clarify whether 12-lipoxygenase (12-LOX) activation was involved in reactive oxygen species (ROS) generation, extensive poly(ADP-ribose) polymerase (PARP) activation and neuronal death induced by glucose-deprivation, followed by glucose-reload (GD/R). The decrease of neuronal viability and...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2007.09.073
更新日期:2007-12-18 00:00:00
abstract::Diurnal variation of N-acetylserotonin in the retina was studied in male rats housed under a photoperiod of 12 h light and 12 h darkness (lights on at 06.00 h) for two weeks. N-acetylserotonin was extracted from the retina by ethyl acetate at pH less than or equal to 3 and was determined by radioimmunoassay. There is ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(81)90381-5
更新日期:1981-01-20 00:00:00
abstract:OBJECTIVE:Diabetic neuropathic pain (DNP) is one of the most common and severe complications in patients with diabetes. This study aimed to investigate serum brain-derived neurotrophic factor (BDNF) levels in patients with DNP and to evaluate the association between BDNF and disease severity. METHODS:A total of 143 T2...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2021.135655
更新日期:2021-01-21 00:00:00
abstract::Tourette syndrome/chronic tic phenotype (TS-CTD) is a neurological disorder manifested particularly by motor and vocal tics and associated with a variety of behavioral abnormalities. Recently, the mitochondrial ribosomal protein L3 gene (MRPL3) S75N, the DnaJ (Hsp40) homolog subfamily C member 13 gene (DNAJC13) A2057S...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2012.03.097
更新日期:2012-05-23 00:00:00
abstract::Growing amounts of evidence suggest that N-Methyl-d-aspartate (NMDA) receptor mediated glutamate neurotransmission may be involved in the pathophysiology of drug dependence. The NMDA receptor consists of three subfamilies (NR1, NR2, and NR3). The ability of subunit NR3 to negatively modulate the NMDA receptor function...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2016.08.025
更新日期:2016-09-19 00:00:00
abstract::The levels of immunoreactive Leu-enkephalin (ir-Leu-Enk) were measured in acid extract of hearts and lungs of adult normotensive Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats. Heart contents in ir-Leu-Enk were significantly higher in SHR rats (2.67 pmol/g) than in WKY rats (1.5 pmol/g). However, no sign...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(88)90280-7
更新日期:1988-11-22 00:00:00
abstract::The size and somatotopic distribution of corneal afferent neurons in the guinea pig trigeminal ganglion were determined using a retrograde axonal tracing technique. Wheat germ agglutinin-horseradish peroxidase (WGA-HRP) was applied to the central cornea of the guinea pig and the animals were perfusion-fixed 48 h later...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(91)90696-q
更新日期:1991-01-02 00:00:00
abstract::Mitochondrial dysfunction and oxidative stress are often linked to various neurodegenerative disorders including ischemic stroke and Huntington's disease (HD). S-Nitrosoglutathione (GSNO) is an endogenous nitric oxide carrier recently identified as a potent antioxidant capable of neutralizing oxidative stress. In the ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2004.03.028
更新日期:2004-05-27 00:00:00
abstract::The cellular localization of butyrylcholinesterase (E,C 3.1.1.8) in rat cerebellum was determined by immunofluorescence with a monospecific immune serum raised against rat brain butyrylcholinesterase. The antiserum specifically stains only glial cells. ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(83)90068-x
更新日期:1983-08-29 00:00:00
abstract::Spinal cord injury (SCI) triggers pronounced inflammatory responses that are accompanied by neuronal disruption and functional deficits. SCI treatment remains an unmet clinical need. Emerging evidence suggests that riluzole may exert a neuroprotective effect due to its anti-inflammatory properties. However, details of...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2020.134829
更新日期:2020-04-01 00:00:00
abstract::The study examined whether the generation of the forward propulsive force (PF) during gait initiation resulted mainly from the electromyogram activity of stance ankle plantar flexor muscles (APF) which 'push' on the ground as is generally claimed in the literature. Six unilateral above-knee amputees performed a specif...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(02)00255-0
更新日期:2002-06-07 00:00:00
abstract::This study analyses the finger force sharing using power grip task with adapted experimental conditions. This paradigm limits as much as possible the external constraints when the Index (I), Middle (M), Ring (R) and Little (L) fingers act simultaneously: the thumb did not oppose the other fingers and no secondary mome...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2011.09.050
更新日期:2011-10-31 00:00:00
abstract::Corticotropin-releasing factor (CRF) is present in climbing fibers and their terminations on Purkinje neurons. To determine whether CRF may have a postsynaptic action in this pathway, CRF effects on the electrophysiological properties of cultured cerebellar Purkinje neurons were studied. CRF produced a dose-dependent ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(93)90358-r
更新日期:1993-01-04 00:00:00
abstract::The purpose of the present experiment was to investigate the effect of vision on postural control following a lower limbs muscular fatigue. Ten adult males were asked to maintain a single leg upright posture as immobile as possible in two conditions of no-fatigue and fatigue of the calf muscles. This muscles fatigue w...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(01)01987-5
更新日期:2001-08-03 00:00:00
abstract::Three forms of stress-induced analgesia (electric shock, forced water-swim and novelty) were used to examine the nature of the endogenous antiopiate system. It was hypothesized that a role of the antiopiate system may be to regulate the extent of antinociception within varying environments. The antiopiate properties o...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(88)90527-7
更新日期:1988-02-03 00:00:00
abstract::In this study, we investigated the effect of PSD-95 antisense oligodeoxynucleotides on the phosphorylation of MLK3, JNK3 and interactions of MLK3 and PSD-95 with kainate receptor (GluR6) by immunoprecipitation and immunoblotting. Transient (15 min) brain ischemia was induced by the four-vessel occlusion in Sprague-Daw...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2004.05.082
更新日期:2004-08-26 00:00:00
abstract::Precursor cells have been shown to be affected by oxidative stress, in vivo and vitro, but little is known about the expression of antioxidant mechanisms in neuronal/glial differentiation. We have characterized the expression of Cu/Zn superoxide dismutase (Cu/Zn SOD), one of the main antioxidant proteins involved in t...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2006.03.010
更新日期:2006-06-19 00:00:00
abstract::To determine how position sense depends on the functional state of the receptors involved, we assessed the accuracy of knee position sense before and after a moderate exercise on a cycle ergometer. Measurements were done on 32 healthy subjects with four protocols combining two tasks (intramodal: using the contralatera...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(00)01297-0
更新日期:2000-08-04 00:00:00
abstract::In vitro quantitative autoradiography was used to visualize nicotinic receptors in large cryosections of human brain hemispheres. Sections 80 microns thick of human brain hemispheres were incubated with (-)-[3H]nicotine and the distribution of nicotinic receptors in human brain was studied. Increasing numbers of nicot...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(89)90540-5
更新日期:1989-07-03 00:00:00
abstract::The specific mRNA of myelin basic protein (MBP) was isolated from active myelinating rat brains. The isolated mRNA was able to direct the synthesis of immunochemically detectable MBP in a wheat-germ cell free protein synthesis system. There was, however, no evidence of neuronal translational control of the in vitro MB...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(82)90370-6
更新日期:1982-03-17 00:00:00
abstract::The sexual axis of rats can be rendered photoresponsive by testosterone implants. We have studied in these conditions whether rat pars tuberalis (PT) melatonin receptor density would be decreased after exposure to short photoperiod (SP) like as observed in long day seasonal breeders. The answer is no, but we observed ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(96)12903-7
更新日期:1996-08-16 00:00:00
abstract::Hippocampal output is mediated via the subiculum, which is the principal target of CA1 pyramidal cells, and which sends projections to a variety of cortical and subcortical regions. Pyramidal cells in the subiculum display two different firing modes and are classified as being burst-spiking or regular-spiking. In a pr...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.11.012
更新日期:2009-01-16 00:00:00
abstract::beta-Amyloid protein immunoreactivity in neocortex and hippocampus of Alzheimer's disease and control brains has been measured using an automatic image analysis system. Successive fields from the pial surface to white matter in 4 neocortical sites, parahippocampal gyrus and along the pyramidal cell layer in the hippoc...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(91)90733-a
更新日期:1991-08-05 00:00:00
abstract::The anatomical relationships between pro-opiomelanocortin-containing axons and serotonin neurons in the nucleus raphe dorsalis (NRD) of the rat were examined at the light microscope level with antibodies against CLIP (corticotropin-like intermediate lobe peptide), alpha-MSH (alpha-melanocyte-stimulating hormone) and s...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(91)90217-h
更新日期:1991-09-02 00:00:00
abstract::The mechanisms underlying aggregate formation in age-related neurodegenerative diseases remain not well understood. Here we investigated whether dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A (Dyrk1A) is involved in the formation of regulator of calcineurin 1 (RCAN1) aggregates. We show that RCAN1 s...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2013.08.066
更新日期:2013-10-25 00:00:00
abstract::Throughout life, new neurons are continuously generated from subventricular zone and added to the olfactory bulb (OB). Because a subset of mature OB neurons undergoes spontaneous cell death, adult OB neurogenesis serves for the replacement of this cell loss. Spontaneous cell turnover should alter the neuronal circuits...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2013.05.017
更新日期:2013-08-26 00:00:00
abstract::Twelve human subjects performed a reciprocal precision aiming task of varying difficulty (index of difficulty=4, 5, or 6) while vision of the ongoing movement was available either continuously or intermittently. In the intermittent conditions, vision of the moving end-effector was available at regular intervals (equal...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(02)01003-0
更新日期:2002-11-22 00:00:00