Differences in the composition of chromaffin granules in adrenaline and noradrenaline containing cells of bovine adrenal medulla.

Abstract:

:Several constituents of chromaffin granules were quantitatively determined in noradrenaline and adrenaline cells purified from bovine adrenal medulla. As far as secretory peptides are concerned noradrenaline granules contained slightly more secretogranin II, but much less chromogranin A than adrenaline granules. This can be explained by the dependence of the biosynthesis of chromogranin A on corticosteroids. Proteolytic processing of chromogranin A and secretogranin II was higher in noradrenaline cells which was paralleled by a higher content of the prohormone convertase PC2. Noradrenaline granules also contained a higher concentration of the vesicular monoamine transporter (vMAT2). No differences were found for dopamine beta-hydroxylase, prohormone convertase PC1, carboxypeptidase H and synaptophysin. These results indicate that the secretory cocktail of peptides released from these cells differs significantly between adrenaline and noradrenaline storing cells.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Weiss C,Cahill AL,Laslop A,Fischer-Colbrie R,Perlman RL,Winkler H

doi

10.1016/0304-3940(96)12712-9

subject

Has Abstract

pub_date

1996-06-14 00:00:00

pages

29-32

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304394096127129

journal_volume

211

pub_type

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