Immunochemical and immunohistochemical characterization of a synaptic membrane protein that binds the competitive antagonists of NMDA receptors.

abstract：:In this study, we have developed a microarray including 1467 cDNAs that were selected to specifically measure stress response in peripheral blood leukocytes. Venous blood was collected from 10 graduate students 2 h before and 2 or 24 h after an open presentation for their Ph.D. The mRNA levels in leukocytes were compa...

journal_title：Neuroscience letters

authors： Morita K,Saito T,Ohta M,Ohmori T,Kawai K,Teshima-Kondo S,Rokutan K

更新日期：2005-06-10 00:00:00

abstract：:Nerve plexuses showing 5-hydroxytryptamine (5-HT)-like immunoreactivity (5-HTLI) have been demonstrated in all the major cerebral arteries of the rat using fluorescence immunohistochemistry on whole-mount stretch preparations. Following bilateral superior cervical ganglionectomy, nerves disappeared from all the vessel...

journal_title：Neuroscience letters

authors： Cowen T,Alafaci C,Crockard HA,Burnstock G

更新日期：1987-07-22 00:00:00

abstract：:The actions of vasoactive intestinal polypeptide (VIP) were investigated on superficial dorsal horn (LI-IV) neurones in longitudinal slices of the rat lumbar spinal cord in vitro. Bath application of VIP (1-2 mM) cause depolarizations which were accompanied by a lowering of the threshold for excitation of the neurone ...

journal_title：Neuroscience letters

authors： Liu XH,Morris R

更新日期：1999-11-26 00:00:00

abstract：:P2Y(1) is probably an important subtype of purinergic receptors (P2Rs) in modulation of the astrocyte activation in spinal cord. The aim of this study was to observe the effect of P2Y(1) receptor on the abnormal energy metabolism of the cultured rat spinal astrocyte induced by extracellular adenosine diphosphate (ADP)...

journal_title：Neuroscience letters

authors： Cui J,Ou S,He WJ,Du L,Zhao YD,Ruan HZ

更新日期：2011-10-10 00:00:00

abstract：:The mechanism of action of the 'geste antagonistique', or sensory trick, used by patients with dystonic blepharospasm (BSP) to transiently diminish their symptoms is presently unknown. In this paper we examined the effects induced by a sensory trick consisting of finger contact with the face on the electrically induce...

journal_title：Neuroscience letters

authors： Gómez-Wong E,Martí MJ,Cossu G,Fabregat N,Tolosa ES,Valls-Solé J

更新日期：1998-07-24 00:00:00

abstract：:Lithium has been successfully employed therapeutically for treatment of bipolar depressive illness; however, its mechanism of action is poorly understood. Recently, it has been demonstrated by us that lithium can prevent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) dopaminergic neurotoxicity in mice. From analy...

journal_title：Neuroscience letters

authors： Arraf Z,Amit T,Youdim MB,Farah R

更新日期：2012-05-10 00:00:00

abstract：:Mirror neurons, which have now been found in the human and songbird as well as the macaque, respond to both the observation and the performance of the same action. It has been suggested that their matching response properties have evolved as an adaptation for action understanding; alternatively, these properties may a...

journal_title：Neuroscience letters

authors： Catmur C

更新日期：2013-04-12 00:00:00

abstract：:To elucidate the mechanisms of individual differences in pain and analgesic sensitivity, we analyzed the variable number of tandem repeat polymorphism in the third exon of the dopamine D4 receptor gene. Alleles that were less than four repeats long and four or more repeats long were considered Short and Long, respecti...

journal_title：Neuroscience letters

authors： Aoki Y,Nishizawa D,Kasai S,Fukuda K,Ichinohe T,Yamashita S,Ikeda K

更新日期：2013-05-10 00:00:00

abstract：:Motor and sensory neuropathies with the clinical features of HMSN III (Dejerine-Sottas syndrome, DSS) are etiologically related to heterozygous mutations in either peripheral myelin protein-22 (PMP22) or myelin protein zero (MPZ). Heterozygous mutations in either of these two genes are also responsible for other hered...

journal_title：Neuroscience letters

authors： Stögbauer F,Young P,Wiebusch H,Timmerman V,Kuhlenbäumer G,Nelis E,Ringelstein EB,Kurlemann G,Assmann G,Van Broeckhoven C,Funke H

更新日期：1998-01-02 00:00:00

abstract：:Anti-Hu is an autoantibody that recognizes an antigen (Hu) highly restricted to neuronal nuclei. In the developing rat brain all neurons and the germinal cell layer were anti-Hu positive. Ependyma and choroid plexus were positive only in the early stages of development. The strongest expression of Hu was seen in the m...

journal_title：Neuroscience letters

authors： Graus F,Ferrer I

更新日期：1990-04-20 00:00:00

abstract：:Interleukin-6 (IL-6) has been shown to have potent neurotrophic activity on peripheral and central neurons in vitro. However, it remains to be determined whether or not IL-6 rescues hippocampal CA1 neurons from lethal ischemia and prevents ischemia-induced learning disability. In the present in vivo study, we infused ...

journal_title：Neuroscience letters

authors： Matsuda S,Wen TC,Morita F,Otsuka H,Igase K,Yoshimura H,Sakanaka M

更新日期：1996-02-02 00:00:00

abstract：:The aim of the present study was to investigate whether mice with a deletion of the gene that encodes the protein kinase C gamma (PKC gamma) isoform could affect the G-protein activation mediated through the opioid receptor-like (ORL-1) receptor and mu-opioid receptor in the mouse pons/medulla and spinal cord, monitor...

journal_title：Neuroscience letters

authors： Narita M,Mizoguchi H,Khotib J,Suzuki M,Ozaki S,Yajima Y,Narita M,Tseng LF,Suzuki T

更新日期：2002-10-04 00:00:00

abstract：:Morphine injections in 16-day-old rats caused an increase in norepinephrine concentration in both superior cervical ganglion and iris after 1 h. Although the increase in the ganglion was blocked by naloxone pretreatment, the increase in the iris was not prevented. The morphine-induced increase did not require the pres...

journal_title：Neuroscience letters

authors： Mattio TG,Kirby ML

更新日期：1983-09-09 00:00:00

abstract：:As the pre-dementia phase of Alzheimer disease, mild cognitive impairment (MCI) involves the onset and development of cognitive impairments. Opioid receptors play pivotal roles in the regulation of learning and cognition. Our study focused on the association of OPRK1 and OPRM1 methylation with MCI in Xinjiang Uygur an...

journal_title：Neuroscience letters

authors： Liu G,Ji H,Liu J,Xu C,Chang L,Cui W,Ye C,Hu H,Chen Y,Zhou X,Duan S,Wang Q

更新日期：2017-01-01 00:00:00

abstract：:Cortical spreading depression (SD) may produce some symptoms of the aura of classical migraine but it is less probable that it can account for the headache. The aversiveness of SD was examined in unanesthetized rats. In Exp. 1, rats with implanted cortical cannulae were confined in the dark compartment of the step-thr...

journal_title：Neuroscience letters

authors： Koroleva VI,Bures J

更新日期：1993-01-12 00:00:00

abstract：:This work investigates the design of a new method to evaluate the importance of visual elements taken into account by a handball goalkeeper facing a thrower. Virtual reality was used to design and reproduce standardised situations in a controlled environment. Under such conditions, it was possible to isolate for inves...

journal_title：Neuroscience letters

authors： Bideau B,Multon F,Kulpa R,Fradet L,Arnaldi B,Delamarche P

更新日期：2004-11-30 00:00:00

abstract：:The purpose of this study was to identify the subcortical neural pathways which mediate adrenocortical responses following cortical stimulation. The frontal cortex was stimulated in intact rats and in animals with medial or lateral septal or preoptic lesions or with large or small anterior hypothalamic deafferentation...

journal_title：Neuroscience letters

authors： Feldman S,Conforti N

更新日期：1987-01-02 00:00:00

abstract：:Aquaporin-1 (AQP1) is a water channel expressed in the choroid plexus and participates in forming cerebrospinal fluid. Interestingly, reactive astrocytes also express AQP1 in the central nervous system under some pathological conditions. On the other hand, 3-nitropropionic acid (3NP) is a mitochondrial toxin that caus...

journal_title：Neuroscience letters

authors： Hoshi A,Tsunoda A,Yamamoto T,Tada M,Kakita A,Ugawa Y

更新日期：2016-07-28 00:00:00

abstract：:Nicotine is known to stimulate energy expenditure, although the precise mechanism is unclear. To clarify the involvement of corticotropin-releasing factor (CRF) in the mechanism by which nicotine increases energy expenditure, the effect of intraperitoneal injection of nicotine (0.1 or 0.5mg/kg) on the release of norad...

journal_title：Neuroscience letters

authors： Mano-Otagiri A,Iwasaki-Sekino A,Ohata H,Arai K,Shibasaki T

更新日期：2009-05-08 00:00:00

abstract：:We studied the extracellular concentration of glutamate and taurine in the frontal cortex of freely-moving pentylenetetrazole (PTZ) kindled rats using an in vivo microdialysis. A significant and sustained increase in the glutamate level was observed in the kindled rats, in contrast, a slight and delayed increase was o...

journal_title：Neuroscience letters

authors： Li Z,Yamamoto Y,Morimoto T,Ono J,Okada S,Yamatodani A

更新日期：2000-03-17 00:00:00

abstract：:The involvement of L-type calcium channels in heterosynaptic long-term depression (LTD) of the stratum radiatum input to area CA1 was studied in rat hippocampal slices. LTD of the radiatum field excitatory postsynaptic potential (EPSP) and population spike, produced by tetanization of the alveus in the presence of pic...

journal_title：Neuroscience letters

authors： Wickens JR,Abraham WC

更新日期：1991-09-02 00:00:00

abstract：:By recording the locomotor activity rhythm of hagfish, Eptatretus burgeri, in which surgical lesions of the preoptic nucleus (PON) were made, we searched for the location of the circadian pacemaker in the hypothalamus. The characteristic rhythms were lost in animals lacking the anterior part of the hypothalamus, which...

journal_title：Neuroscience letters

authors： Ooka-Souda S,Kadota T,Kabasawa H

更新日期：1993-12-24 00:00:00

abstract：:Three variations of the in vitro neonatal rat spinal cord preparation were used to investigate motor responses to stimulation of the ventrolateral funiculus (VLF). In a partially hemisected spinal cord preparation, stimuli elicited frequency-dependent activity in lumbar ventral roots that outlasted the stimulus train ...

journal_title：Neuroscience letters

authors： Magnuson DS,Schramm MJ,MacLean JN

更新日期：1995-06-09 00:00:00

abstract：:Two electrophysiologically distinct cell types were found with intracellular recordings for the first time in an in vitro preparation of the olfactory epithelium of the salamander, Ambystoma tigrinum. Intracellular recordings showed that Type I cells did not discharge action potentials but had high resting membrane po...

journal_title：Neuroscience letters

authors： Masukawa LM,Kauer JS,Shepherd GM

更新日期：1983-01-31 00:00:00

abstract：:8-OH-DPAT is a 5-HT(1A/7) receptor agonist that enhances behavioral recovery after traumatic brain injury (TBI). This study is a first attempt to decipher whether the benefits induced by 8-OH-DPAT after TBI are mediated by 5-HT(1A) or 5-HT(7) receptors. A single i.p. injection of 8-OH-DPAT (0.5 mg/kg) alone or co-admi...

journal_title：Neuroscience letters

authors： Yelleswarapu NK,Tay JK,Fryer WM,Shah MA,Garcia AN,Cheng JP,Kline AE

更新日期：2012-05-02 00:00:00

abstract：:The superoxide (O2.-) scavenging activity and the neuroprotective effects of pterin-6-aldehyde (P6A), a xanthine oxidase inhibitor, were examined and compared with those of alpha-phenyl-N-tert-butyl nitrone (PBN), a spin trapping agent. The scavenging activity of P6A was more potent than that of PBN by 150-fold in neu...

journal_title：Neuroscience letters

authors： Mori H,Arai T,Ishii H,Adachi T,Endo N,Makino K,Mori K

更新日期：1998-01-30 00:00:00

abstract：:Extracellular recordings were obtained from 58 phasically active neurosecretory neurons in the hypothalamic paraventricular nucleus (PVN) of urethane-anesthetized male rats. Of these PVN neurons, 39 exhibited an increase and 11 displayed a reduction in ongoing activity following electrical stimulation of the subfornic...

journal_title：Neuroscience letters

authors： Tanaka J,Saito H,Seto K

更新日期：1988-10-05 00:00:00

abstract：:The effects of the group III mGluR agonist, L-2-amino-4-phosphonobutyrate (L-AP4), on depolarization-stimulated cGMP levels in adult rat cerebellar slices were determined. L-AP4 elicited a concentration-dependent, complete inhibition of cGMP formation stimulated by 4-aminopyridine (4-AP; 1 mM), yielding an IC50 value ...

journal_title：Neuroscience letters

authors： Cartmell J,Kemp JA,Mutel V

更新日期：1997-06-13 00:00:00

abstract：:In micturition control, the roles of ionotropic glutamate (iGlu) receptors NMDA and AMPA are well established, whereas little is known about the function of metabotropic glutamate (mGlu) receptors. Since antagonists for mGlu5 receptors are efficacious in animal models of inflammatory and neuropathic pain, we examined ...

journal_title：Neuroscience letters

authors： Hu Y,Dong L,Sun B,Guillon MA,Burbach LR,Nunn PA,Liu X,Vilenski O,Ford AP,Zhong Y,Rong W

更新日期：2009-01-23 00:00:00

abstract：:Incorporation of the N-methyl-d-aspartate receptor (NMDAR) subunit NR3A into functional NMDARs results in reduced channel conductance and Ca(2+) permeability. To further investigate the function of NR3A, we have set out to characterize its intracellular binding partners. Here, we report a novel protein interaction bet...

journal_title：Neuroscience letters

authors： Eriksson M,Samuelsson H,Björklund S,Tortosa E,Avila J,Samuelsson EB,Benedikz E,Sundström E

更新日期：2010-05-07 00:00:00