当前位置： SCI文献检索 > NEUROSCIENCE LETTERS期刊下所有文献 > Proteomic analysis of time-dependent changes in proteins expressed in mouse hippocampus during synaptic plasticity induced by GABAA receptor blockade.

Proteomic analysis of time-dependent changes in proteins expressed in mouse hippocampus during synaptic plasticity induced by GABAA receptor blockade.

Abstract：

:Protein synthesis is required for long-lasting synaptic plasticity. We examined the time-dependent changes in protein expression that occurred in the hippocampus during synaptic plasticity using two-dimensional gel electrophoresis followed by mass spectrometry. The levels of 15 proteins were significantly changed in mouse hippocampus 8h after bicuculline application (1.0mg/kg, i.p.). Expression of 14 proteins (i.e., dihydropyrimidinase-related protein 2, α-tubulin isotype M-α-2, tubulin β-1 chain, tubulin β-2A chain, protein disulfide-isomerase ERp61 precursor, chaperonin-containing T complex polypeptide 1 β subunit, T complex polypeptide 1 [partial], creatine kinase B-type, cytosolic malate dehydrogenase [partial], vacuolar adenosine triphosphatase subunit A, and uncharacterized protein LOC433182) was increased and expression of one protein (i.e., actin γ, cytoplasmic 1) was decreased. Western blotting also validated the changes in dihydropyrimidinase-related protein 2, creatine kinase B-type, and vacuolar adenosine triphosphatase subunit A levels in mouse hippocampus 8h after bicuculline application. The identified proteins were effectors of cellular functions including neuronal differentiation, cytoskeletal dynamics, folding of proteins, stress response, energy metabolism, synapse formation, and unknown function. Taken together, these findings indicate that the identified proteins play an important role in synaptic plasticity in the hippocampus.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Matsuura K,Nakamura-Hirota T,Takano M,Otani M,Kadoyama K,Matsuyama S

doi

10.1016/j.neulet.2013.07.036

subject

Has Abstract

pub_date

2013-10-25 00:00:00

pages

18-23

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(13)00682-4

journal_volume

555

pub_type

杂志文章

相关文献

NEUROSCIENCE LETTERS文献大全
  • Neonatal rat brain astroglial dipeptidyl peptidase II activity regulation by cations and anions.

    abstract：:Astrocytic glial cells from neonatal rat brains were grown in primary culture. Dipeptidyl peptidase II (DPP-II) enzyme activity was measured in cells disrupted by nonionic detergent. The rate of enzyme activity was measured in the presence of various ions, under isosmotic conditions adjusted using mannitol and NaCl. D...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(88)90546-0

    authors： Stevens BR,Fernandez A,Sumners C,Hearing L

    更新日期：1988-07-08 00:00:00

  • Adrenergic neurons in sheep brain demonstrated by immunohistochemistry with antibodies to phenylethanolamine N-methyltransferase (PNMT) and dopamine-beta-hydroxylase (DBH): absence of the C1 cell group in the sheep brain.

    abstract：:Using immunohistochemistry with specific antisera against dopamine-beta-hydroxylase and phenylethanolamine N-methyltransferase, we present the first description of the adrenergic structures of the sheep medulla oblongata. Dopamine-beta-hydroxylase-immunoreactive perikarya in the sheep brain are localized as described ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(88)90641-6

    authors： Tillet Y

    更新日期：1988-12-19 00:00:00

  • Substance P modulation of striatal dopamine outflow is determined by M(1) and M(2) muscarinic receptors in male wistar rats.

    abstract：:Substance P (SP) stimulates striatal dopamine outflow through a cholinergic muscarinic link. SP-induced increase in acetylcholine (Ach) is concentration-dependent, whereas the stimulation of dopamine outflow is seen only over a limited concentration range. M(1) and M(2) receptor stimulation has opposite effects on dop...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(00)01529-9

    authors： Khan S,Whelpton R,Michael-Titus AT

    更新日期：2000-11-03 00:00:00

  • Beta-alanine induced ion channels in the membrane of cultured spinal cord neurons.

    abstract：:beta-Alanine (beta-ALa) is a structural analog of the putative inhibitory transmitters gamma-aminobutyric acid (GABA) and glycine. beta-ALa itself depresses firing in cultured mouse spinal cord (SC) neurons, by selectively increasing membrane conductance to chloride ions. Patch clamp recordings now reveal that beta-AL...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(90)90718-o

    authors： Mathers DA,Grewal A,Wang YH

    更新日期：1990-01-01 00:00:00

  • Absence of SHATI/Nat8l reduces social interaction in mice.

    abstract：:We previously identified a novel molecule "Shati/Nat8l" from the nucleus accumbens of mice. However, the physiological roles of the SHATI protein are not clear. To investigate the effect of SHATI on the central nervous system and behavior, we studied knockout mice of this protein. We carried out various behavior tests...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2012.08.028

    authors： Furukawa-Hibi Y,Nitta A,Fukumitsu H,Somiya H,Toriumi K,Furukawa S,Nabeshima T,Yamada K

    更新日期：2012-09-27 00:00:00

  • The posterior pretectal nucleus: evidence for a direct projection to the inferior olive of the cat.

    abstract：:In our horseradish peroxidase (HRP) study of the afferents to the medullary raphe nuclei in the cat, HRP uptake by damaged axons en route to the inferior olive (IO) was thought to be responsible for retrograde labelling of specific midbrain nuclei. To control for such indirect labelling, HRP was injected iontophoretic...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(79)90026-0

    authors： Abols IA,Basbaum AI

    更新日期：1979-07-01 00:00:00

  • Acute effects of cryotherapy on postural control.

    abstract：:To investigate the acute effects of whole-body cryotherapy (WBC) on postural control, we measured postural sway (COP) in a quiet stance with eyes open in four consecutive 20-second tests: before and 1, 6 and 11min after the WBC. Twenty-four healthy young subjects aged 19.3±0.9 were exposed to WBC (-110°C) for 2min. Th...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2012.12.037

    authors： Giemza C,Czech P,Paluszak A,Bieć E,Borzucka D,Kuczyński M

    更新日期：2013-03-01 00:00:00

  • Corticotropin-releasing factor suppresses the afterhyperpolarization in cerebellar Purkinje neurons.

    abstract：:Corticotropin-releasing factor (CRF) is present in climbing fibers and their terminations on Purkinje neurons. To determine whether CRF may have a postsynaptic action in this pathway, CRF effects on the electrophysiological properties of cultured cerebellar Purkinje neurons were studied. CRF produced a dose-dependent ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(93)90358-r

    authors： Fox EA,Gruol DL

    更新日期：1993-01-04 00:00:00

  • The impact of physical activity on motor preparation in young adults.

    abstract：:Regular physical activity benefits brain health and function. Physical activity performed by young adults is declining. However, the influence of diminished physical activity on cognitive performance and motor preparation in young adults remains unclear. This study measured changes in behavior and brain activity durin...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2016.12.045

    authors： Cirillo J,Finch JB,Anson JG

    更新日期：2017-01-18 00:00:00

  • Mediodorsal thalamic stimulation is not protective against seizures induced by amygdaloid kindling in rats.

    abstract：:Deep brain stimulation (DBS) is now emerging as a new option for treating intractable epilepsy. Cumulative studies suggest that the mediodorsal thalamic nucleus (MD) is involved in limbic seizure activity. This study aims to investigate whether DBS of the MD can protect against seizures induced by amygdaloid kindling....

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2010.06.060

    authors： Wang S,Wu DC,Fan XN,Zhu MZ,Hu QY,Zhou D,Ding MP,Chen Z

    更新日期：2010-09-06 00:00:00

  • Marked variations of the relative distributions of neurotensin and neuromedin N in micropunched rat brain areas suggest differential processing of their common precursor.

    abstract：:Neuromedin N (NN) is a hexapeptide that shares a four amino acid identity with the C-terminus of neurotensin (NT) and exhibits NT-like effects in the central nervous system. Both peptides were recently shown to be encoded in the same precursor molecule. By means of specific and sensitive radioimmunoassays, we compared...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(91)90810-g

    authors： Kitabgi P,Masuo Y,Nicot A,Berod A,Cuber JC,Rostène W

    更新日期：1991-03-11 00:00:00

  • Long-interval facilitation and inhibition are differentially affected by conditioning stimulus intensity over different time courses.

    abstract：:Intracortical facilitatory and inhibitory processes in the primary motor cortex (M1) play an important role in both the preparation and execution of motor tasks. Here we aimed to (1) confirm the existence of, and further characterise, intracortical facilitation at long conditioning-test stimulus intervals at subthresh...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2014.03.060

    authors： Vallence AM,Schneider LA,Pitcher JB,Ridding MC

    更新日期：2014-06-06 00:00:00

  • Increases in cytosolic Ca2+ in rat area postrema/mNTS neurons produced by angiotensin II and arginine-vasopressin.

    abstract：:It is well established that neurons in the dorsal medulla, including the area postrema and the medial nucleus tractus solitarius (mNTS), are involved in the central actions of circulating peptides such as angiotensin II (ANG II) and arginine vasopressin (AVP). This report describes a preparation that permits the ident...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(93)90001-2

    authors： Hay M,Edwards GL,Lindsley K,Murphy S,Sharma RV,Bhalla RC,Johnson AK

    更新日期：1993-03-19 00:00:00

  • Effect of calcium on the histochemical distribution and intensity of biogenic amine-containing neurons in the mouse brain.

    abstract：:The effect of calcium on the biogenic amine level and distribution in the mouse brain was investigated by a histochemical method using a microscopic photometer (Pl, Nikon). Histochemical fluorescence intensities in the corpus striatum and cortex cerebri regions were significantly increased by the intraventricular admi...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(86)90422-2

    authors： Sutoo D,Akiyama K

    更新日期：1986-08-15 00:00:00

  • Dextromethorphan does not protect against quinolinic acid neurotoxicity in rat striatum.

    abstract：:Dextromethorphan (DM, 40 or 80 mg/kg, i.p.) and MK-801 (3 or 10 mg/kg, i.p.) were compared in their ability to prevent the depletion of choline acetyltransferase (ChAT) activity in the rat striatum following intrastriatal injection of quinolinic acid. DM did not reduce striatal ChAT depletion following injection of ei...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(88)90669-6

    authors： Engber TM,Chase TN

    更新日期：1988-12-19 00:00:00

  • In vivo release of enkephalin from the globus pallidus.

    abstract：:Push-pull cannulae were acutely positioned through previously implanted guides in the globus pallidus of unanesthetized freely moving cats and rats. During slow-flow perfusions, enkephalin release was detected in resting conditions and increased more than 3-fold when both 50 mM K+ and 1.8 mM Ca2+ were present in the p...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(81)90360-8

    authors： Bayon A,Shoemaker WJ,Lugo L,Azad R,Ling N,Drucker-Colin RR,Bloom FE

    更新日期：1981-06-12 00:00:00

  • The inhibition by indoleamines (tryptamine and serotonin) of ocular serotonin-N-acetyltransferase from Rana perezi is temperature-dependent.

    abstract：:Temperature effects on ocular serotonin N-acetyltransferase (NAT) kinetics characteristics from Rana perezi have been studied with respect to tryptamine and serotonin as substrates. Monoamine oxidase (MAO) activity does not interfere in NAT assay at acceptoramine concentrations used in NAT kinetics characterization fr...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(93)90667-a

    authors： Alonso-Gómez AL,Alonso-Bedate M,Delgado MJ

    更新日期：1993-05-28 00:00:00

  • Expression of neuronal isoform of nitric oxide synthase in spinal neurons of neonatal rats after sciatic nerve transection.

    abstract：:Motoneuron death induced by sciatic nerve transection in neonatal rats has been related to induction of the neuronal isoform of nitric oxide synthase (nNOS), a diaphorase of which one of the cofactors is nicotinamide adenine dinucleotide phosphate (NADPH). We transected the sciatic nerve of neonatal rats (P2) and exam...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(01)01931-0

    authors： Rogério F,Teixeira SA,de Souza Queiroz L,De Nucci G,Langone F

    更新日期：2001-07-13 00:00:00

  • Vasoactive intestinal peptide (VIP)-like immunoreactive neurons located in the rat suprachiasmatic nucleus receive a direct retinal projection.

    abstract：:The existence of a direct projection from retinal ganglion cells to vasoactive intestinal peptide (VIP)-like immunoreactive neuronal elements in the rat suprachiasmatic nucleus (SCN) was revealed by combining analysis of degenerating axons following enucleation and electron microscopic immunocytochemistry. Degeneratin...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(89)90129-8

    authors： Ibata Y,Takahashi Y,Okamura H,Kawakami F,Terubayashi H,Kubo T,Yanaihara N

    更新日期：1989-02-13 00:00:00

  • Luteolin attenuates interleukin-6-mediated astrogliosis in human iPSC-derived neural aggregates: A candidate preventive substance for maternal immune activation-induced abnormalities.

    abstract：:Maternal infection during pregnancy increases the risk of neurodevelopmental conditions such as autism spectrum disorders and schizophrenia in offspring. Several previous animal studies have indicated that maternal immune activation (MIA), rather than a specific pathogen, alters fetal brain development. Among them, pr...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2017.06.004

    authors： Zuiki M,Chiyonobu T,Yoshida M,Maeda H,Yamashita S,Kidowaki S,Hasegawa T,Gotoh H,Nomura T,Ono K,Hosoi H,Morimoto M

    更新日期：2017-07-13 00:00:00

  • Depression of the firing of rat cerebral cortical neurons by 2-azido analogues of adenine nucleotides.

    abstract：:Iontophoretically applied 2-azido photoaffinity analogues of adenosine 5'-triphosphate (ATP) and adenosine 5'-monophosphate (AMP) have been tested on rat cerebral cortical neurons. 2-Azido-AMP and 2-azido-ATP had a powerful depressant action on the spontaneous firing of cortical neurons. Both compounds were equipotent...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(81)90058-6

    authors： Phillis JW

    更新日期：1981-01-01 00:00:00

  • Exposure of rat hippocampal neurons to amyloid beta peptide (25-35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3 beta.

    abstract：:Exposure of rat hippocampal neurons to the peptide amyloid beta (A beta) (25-35) as well as A beta (1-40) peptides enhances phosphorylation of tau to a paired helical filament (PHF)-state through activation of tau protein kinase I (TPK I)/glycogen synthase kinase-3 beta (GSK-3 beta) [Busciglio, J., Lorenzo, A., Yeh, J...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(95)12257-5

    authors： Takashima A,Noguchi K,Michel G,Mercken M,Hoshi M,Ishiguro K,Imahori K

    更新日期：1996-01-12 00:00:00

  • The direct pathway from the brainstem reticular formation to the cerebral cortex in the ascending reticular activating system: A diffusion tensor imaging study.

    abstract：:Precise evaluation of the ascending reticular activating system (ARAS) is important for diagnosis, prediction of prognosis, and management of patients with disorders of impaired consciousness. In the current study, we attempted to reconstruct the direct neural pathway between the brainstem reticular formation (RF) and...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2015.09.004

    authors： Jang SH,Kwon HG

    更新日期：2015-10-08 00:00:00

  • Influence of the apolipoprotein E epsilon4 allele on human embryonic development.

    abstract：:Human apolipoprotein E (apoE) exists in three major isoforms encoded by distinct alleles (APOE epsilon2, epsilon3 and epsilon4) and has important functions in nerve development and repair. Inheritance of the 4 allele is a major risk factor for the development of Alzheimer's disease. To investigate the role of APOE pol...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(02)00198-2

    authors： Zetterberg H,Palmér M,Ricksten A,Poirier J,Palmqvist L,Rymo L,Zafiropoulos A,Arvanitis DA,Spandidos DA,Blennow K

    更新日期：2002-05-24 00:00:00

  • The astrocyte marker Aldh1L1 does not reliably label enteric glial cells.

    abstract：:Enteric glial cells are increasingly acknowledged as important partners of enteric neurons in the control of gastrointestinal function. They share morphological features and expression of antigenic markers with astrocytes of the central nervous system. Recently, aldehyde dehydrogenase 1 family member L1 (Aldh1L1) has ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2014.02.042

    authors： Boesmans W,Rocha NP,Reis HJ,Holt M,Vanden Berghe P

    更新日期：2014-04-30 00:00:00

  • Cerebellar involvement in verb generation: an fMRI study.

    abstract：:A possible role of the human cerebellum in the generation of verbs corresponding to presented nouns has been suggested. Previous functional brain imaging studies have compared generation of verbs with the reading of nouns as a measure of verb generation. In the present fMRI study involving healthy human subjects, the ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2006.08.058

    authors： Frings M,Dimitrova A,Schorn CF,Elles HG,Hein-Kropp C,Gizewski ER,Diener HC,Timmann D

    更新日期：2006-11-27 00:00:00

  • A subset of nociceptin/orphanin FQ receptor-expressing neurons in the anterior hypothalamic area, as revealed in mice with lacZ reporter gene.

    abstract：:Nociceptin/orphanin FQ (N/OFQ) is an endogenous peptide agonist for the opioid receptor homolog, N/OFQ receptor, and serves for the central control of autonomic functions. Morphological details including the cell types that may account for such N/OFQ functions, however, remain unclear. By using X-gal histochemistry fo...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(02)01186-2

    authors： Houtani T,Ikeda M,Kase M,Sato K,Sakuma S,Kakimoto S,Ueyama T,Munemoto Y,Takeshima H,Sugimoto T

    更新日期：2003-01-02 00:00:00

  • Role of alpha 1 and alpha 2-adrenoceptors of the lateral hypothalamic area on urinary excretion caused by centrally administered angiotensin II.

    abstract：:To determine whether central alpha 1 and alpha 2-adrenergic mechanisms are involved in urinary sodium and potassium excretion and urine volume induced by angiotensin II (ANGII), these renal parameters were measured in volume-expanded Holtzman rats with cannulas implanted into lateral ventricle (LV) and lateral hypotha...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(95)11751-h

    authors： Saad WA,Camargo LA,Renzi A,Menani JV,Saad WA

    更新日期：1995-07-21 00:00:00

  • Greater electroencephalographic coherence between left and right temporal lobe structures during increased geomagnetic activity.

    abstract：:Interhemispheric coherence for 19 channel EEG activity collected over a three year period from 184 men and women who relaxed in a quiet, darkened chamber showed significant increased coherence between caudal temporal regions for the 11 Hz frequency band during increased (>∼8 nT) global geomagnetic activity at the time...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2013.11.024

    authors： Saroka KS,Caswell JM,Lapointe A,Persinger MA

    更新日期：2014-02-07 00:00:00

  • Differential palmitoylation of two mouse glutamate receptor interacting protein 1 forms with different N-terminal sequences.

    abstract：:Glutamate receptor interacting protein (GRIP) is a member of the PDZ domain-containing protein family that is localized in the postsynaptic density area. This protein has been reported to interact specifically with the C-termini of AMPA-selective glutamate receptor channel subunits, GluRalpha2 and GluRalpha3 through i...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(01)01766-9

    authors： Yamazaki M,Fukaya M,Abe M,Ikeno K,Kakizaki T,Watanabe M,Sakimura K

    更新日期：2001-05-18 00:00:00