Abstract:
:beta-Alanine (beta-ALa) is a structural analog of the putative inhibitory transmitters gamma-aminobutyric acid (GABA) and glycine. beta-ALa itself depresses firing in cultured mouse spinal cord (SC) neurons, by selectively increasing membrane conductance to chloride ions. Patch clamp recordings now reveal that beta-ALa-sensitive chloride channels in SC cells can open to at least 5 conductance states, 4 of which are very similar to states seen when GABA or glycine is applied to these cells. However, a large, 80 pS conductance state is activated at detectable frequency only in the presence of beta-ALa itself.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Mathers DA,Grewal A,Wang YHdoi
10.1016/0304-3940(90)90718-osubject
Has Abstractpub_date
1990-01-01 00:00:00pages
127-31issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(90)90718-Ojournal_volume
108pub_type
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