Blockade of nitric oxide formation by N omega-nitro-L-arginine mitigates ischemic brain edema and subsequent cerebral infarction in rats.

abstract：OBJECTIVE:To explore whether the cognitive impairment is correlated with freezing of gait (FOG) in patients with Parkinson disease (PD). METHODS:A total of 186 patients with Parkinson disease (104 patients with FOG and 82 patients with no clinical history of freezing behavior) and 125 healthy individuals were selected...

journal_title：Neuroscience letters

authors： Yao Z,Shao Y,Han X

更新日期：2017-08-24 00:00:00

abstract：:Methylated beta-carboline compounds are mammalian indole metabolites that we have proposed to be endogenous neurotoxins due to their structural similarity to MPP+, the active oxidized product of the dopaminergic toxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Several laboratories have demonstrated that MPP...

journal_title：Neuroscience letters

authors： Neafsey EJ,Drucker G,Raikoff K,Collins MA

更新日期：1989-11-06 00:00:00

abstract：:The effect of a chronic 17 beta-estradiol (10 micrograms, b.i.d.) treatment of 2 weeks to ovariectomized rats was investigated on lateral and medial caudate-putamen dopamine receptors. Dopamine D2 receptors were assayed with [3H]spiperone binding to caudate-putamen homogenates or by autoradiography of forebrain sectio...

journal_title：Neuroscience letters

authors： Falardeau P,Di Paolo T

更新日期：1987-02-10 00:00:00

abstract：:Using a specific radioimmunoassay (RIA), we have quantitated the hypothalamic and extrahypothalamic distribution of vasoactive intestinal polypeptide (VIP) in the rat brain. Highest concentrations of VIP were found in cerebral cortex, suprachiasmatic nucleus, and medial amygdaloid nucleus. Lower concentrations were fo...

journal_title：Neuroscience letters

authors： Samson WK,Said SI,McCann SM

更新日期：1979-05-01 00:00:00

abstract：:The pharmacological properties of presynaptic calcium (Ca) channels on rat hippocampal mossy fiber synaptosomes were characterized by determining the inhibitory potencies for various classes of Ca antagonists on depolarization-induced Ca mobilization and the release of dynorphin A(1-8)-like immunoreactivity (Dyn-LI). ...

journal_title：Neuroscience letters

authors： Terrian DM,Damron DS,Dorman RV,Gannon RL

更新日期：1989-12-04 00:00:00

abstract：:Recent evidence has been presented demonstrating that group III mechanoreceptors comprise an important part of the sensory arm of the exercise pressor reflex, which in turn functions to increase arterial blood flow to contracting skeletal muscles. Although group III afferents are stimulated by mechanical distortion of...

journal_title：Neuroscience letters

authors： Leal AK,Stone AJ,Yamauchi K,McCord JL,Kaufman MP

更新日期：2013-10-25 00:00:00

abstract：:Ca2+ signals regulate most aspects of animal cell life. They are of particular importance to the nervous system, in which they regulate specific functions, from neuronal development to synaptic plasticity. The homeostasis of cell Ca2+ must thus be very precisely regulated: in all cells Ca2+ pumps transport it from the...

journal_title：Neuroscience letters

authors： Calì T,Brini M,Carafoli E

更新日期：2018-01-10 00:00:00

abstract：:The intramedullary axon collateral systems of adult cat spinal alpha-motoneurones were studied with morphological and physiological techniques 12 weeks after peripheral transection of the motor axons. Morphologically, intracellular horseradish peroxidase (HRP) staining showed that the axotomy induced an elimination of...

journal_title：Neuroscience letters

authors： Havton L,Kellerth JO

更新日期：1984-11-23 00:00:00

abstract：:Human apolipoprotein E (apoE) exists in three major isoforms encoded by distinct alleles (APOE epsilon2, epsilon3 and epsilon4) and has important functions in nerve development and repair. Inheritance of the 4 allele is a major risk factor for the development of Alzheimer's disease. To investigate the role of APOE pol...

journal_title：Neuroscience letters

authors： Zetterberg H,Palmér M,Ricksten A,Poirier J,Palmqvist L,Rymo L,Zafiropoulos A,Arvanitis DA,Spandidos DA,Blennow K

更新日期：2002-05-24 00:00:00

abstract：:Post-stroke 'pushing' behaviour appears to be caused by impaired perception of vertical in the roll plane. While pushing behaviour typically resolves with stroke recovery, it is not known if misperception of vertical persists. The purpose of this study was to determine if perception of vertical is impaired amongst str...

journal_title：Neuroscience letters

authors： Mansfield A,Fraser L,Rajachandrakumar R,Danells CJ,Knorr S,Campos J

更新日期：2015-03-17 00:00:00

abstract：:The effects of intrathecal injections of morphine and other opioid receptor selective drugs were tested on urinary bladder contractions in the anesthetized rat. Morphine produced dose-related inhibition of bladder motility which was abolished by naloxone. This action was also observed with mu- and delta-opioid recepto...

journal_title：Neuroscience letters

authors： Dray A,Metsch R

更新日期：1984-06-01 00:00:00

abstract：:Rapid removal of synaptically released glutamate from the extracellular space ensures a high signal-to-noise ratio in excitatory neurotransmission. In the cerebellum, glial glutamate transporters, GLAST and GLT-1, are co-localized in the processes of Bergmann glia wrapping excitatory synapses on Purkinje cells (PCs). ...

journal_title：Neuroscience letters

authors： Takatsuru Y,Iino M,Tanaka K,Ozawa S

更新日期：2007-06-08 00:00:00

abstract：:In urethane-anesthetized rats, injections of 50 pmol of arginine-vasopressin (AVP) or thyrotropin-releasing hormone (TRH) into a lateral cerebral ventricle (i.c.v.) elicit short-latency increases in blood pressure. i.c.v. injection of 50 pmol of the AVP antagonist, d(CH2)5Tyr(Me)AVP, but not of the vehicle (artificial...

journal_title：Neuroscience letters

authors： Pittman QJ,Franklin LG

更新日期：1985-05-14 00:00:00

abstract：:Using a training protocol that effectively induces procedural memory consolidation (PMC) in young adults, we show that older adults are good learners, robustly improving their motor performance during training. However, performance declined over the day, and overnight 'offline' consolidation phase performance gains we...

journal_title：Neuroscience letters

authors： Korman M,Dagan Y,Karni A

更新日期：2015-10-08 00:00:00

abstract：:In order to clarify the participation of substance P in the expression of opiate withdrawal, we have investigated the effects induced by the new selective neurokinin-1 antagonist RP 67580 on naloxone-induced morphine withdrawal syndrome in rats. Intracerebroventricular administration of RP 67580 elicited a decrease in...

journal_title：Neuroscience letters

authors： Maldonado R,Girdlestone D,Roques BP

更新日期：1993-06-25 00:00:00

abstract：:Neuronal density, neuron size, and the number of neurons under 1 mm2 of cerebral cortical surface area were measured in the right pre-frontal cortex of Albert Einstein and five elderly control subjects. Measurement of neuronal density used the optical dissector technique on celloidin-embedded cresyl violet-stained sec...

journal_title：Neuroscience letters

authors： Anderson B,Harvey T

更新日期：1996-06-07 00:00:00

abstract：:We have looked at the effect of synthetic mu-conotoxin GIIIA, a selective blocker of muscle Na channels, on various parameters of synaptic transmission at the frog sartorius nerve-muscle preparation. We found that 5 microM mu-conotoxin consistently blocked muscle action potentials, but had no effect on nerve action po...

journal_title：Neuroscience letters

authors： Sosa MA,Zengel JE

更新日期：1993-07-23 00:00:00

abstract：:Stroke is a major cause of epilepsy, but the molecular mechanisms underlying post-stroke epileptogenesis are unknown. The expression of cystatin C, a cysteine protease inhibitor, is increased in the hippocampus during status epilepticus (SE)-induced epileptogenesis, and regulates both cell death and birth. To test the...

journal_title：Neuroscience letters

authors： Pirttilä TJ,Pitkänen A

更新日期：2006-03-06 00:00:00

abstract：:The effects of systemic hypothermia (33.5 degrees C) on the ischemia-evoked release of the neurotransmitter amino acids, glutamate, aspartate, gamma-amino-butyric acid (GABA) and glycine into rat cerebral cortical superfusates were evaluated in the rat four vessel occlusion model. Glutamate, aspartate and GABA, but no...

journal_title：Neuroscience letters

authors： Simpson RE,Walter GA,Phillis JW

更新日期：1991-03-11 00:00:00

abstract：:APPsw transgenic mice showing substantial features of brain Abeta amyloidosis such as senile plaques and behavioral abnormalities were examined by immunostaining to determine whether Abeta deposits could induce the subsequent disturbance of neurotransmitter systems including somatostatin, substance P and choline acety...

journal_title：Neuroscience letters

authors： Tomidokoro Y,Harigaya Y,Matsubara E,Ikeda M,Kawarabayashi T,Okamoto K,Shoji M

更新日期：2000-10-13 00:00:00

abstract：:Astrocytic glial cells from neonatal rat brains were grown in primary culture. Dipeptidyl peptidase II (DPP-II) enzyme activity was measured in cells disrupted by nonionic detergent. The rate of enzyme activity was measured in the presence of various ions, under isosmotic conditions adjusted using mannitol and NaCl. D...

journal_title：Neuroscience letters

authors： Stevens BR,Fernandez A,Sumners C,Hearing L

更新日期：1988-07-08 00:00:00

abstract：:Twenty years ago, Wolfe, Xia, and Selkoe identified two aspartate residues in Alzheimer's presenilin protein that constitute the active site of the γ-secretase complex. Mutations in the genes encoding amyloid precursor protein (APP) or presenilin (PS) cause early onset familial Alzheimer's disease (AD), and sequential...

journal_title：Neuroscience letters

authors： Xia W

更新日期：2019-05-14 00:00:00

abstract：:Using a new polyclonal antibody against prostacyclin (PGI2)-synthase this enzyme was shown to be present in neuronal cells of bovine, rat and human brain, most abundantly in Purkinje cells of the cerebellum and cortical neurons, but not in glial cells. Western blots confirmed the specificity of the antibody and applie...

journal_title：Neuroscience letters

authors： Mehl M,Bidmon HJ,Hilbig H,Zilles K,Dringen R,Ullrich V

更新日期：1999-08-27 00:00:00

abstract：:This is the first report of the presence of nitric oxide synthase (NOS) immunoreactivity and NADPH-diaphorase (NADPH-d) activity in a subpopulation of the intrinsic neurones that innervate the heart. A cytochemical technique to detect NADPH-d and antisera raised against purified rat cerebellar NOS were employed to exa...

journal_title：Neuroscience letters

authors： Hassall CJ,Saffrey MJ,Belai A,Hoyle CH,Moules EW,Moss J,Schmidt HH,Murad F,Förstermann U,Burnstock G

更新日期：1992-08-31 00:00:00

abstract：:Ischemic cerebrovascular diseases, usually involved in hypoxia and reoxygenation, have been reported to increase the risk of dementia such as Alzheimer's disease (AD). beta-site amyloid protein precursor (APP)-cleaving enzymes (BACE1) have been identified to participate in the secretion of beta-amyloid peptides (Abeta...

journal_title：Neuroscience letters

authors： Xue S,Jia L,Jia J

更新日期：2006-09-25 00:00:00

abstract：:The effects of histamine (HA) on the resting membrane potential and input resistance of rat medial vestibular nucleus (MVN) neurons were investigated using intracellular recording techniques from a submerged brain slice preparation. The exogenous application of HA predominantly produced a concentration-dependent membr...

journal_title：Neuroscience letters

authors： Phelan KD,Nakamura J,Gallagher JP

更新日期：1990-02-16 00:00:00

abstract：:The effect of the spectral tone structure on pre-attentive and attentive pitch discrimination was investigated. The mismatch negativity (MMN) component was recorded from reading subjects to pitch changes of identical magnitude in pure tones with only one sinusoidal frequency component and in spectrally rich tones with...

journal_title：Neuroscience letters

authors： Tervaniemi M,Ilvonen T,Sinkkonen J,Kujala A,Alho K,Huotilainen M,Näätänen R

更新日期：2000-01-21 00:00:00

abstract：:Single-site variants in the calmodulin-binding domain of RC3/neurogranin were heterologously expressed in Xenopus oocytes to examine their effects on serotonin-evoked currents. RC3 variants serine36 -->alanine (Ser36-->Ala), serine36-->glycine (Ser36-->Gly), and phenylalanine37-->tryptophan (Phe37-->Trp), which bind c...

journal_title：Neuroscience letters

authors： Watson JB,Margulies JE,Coulter PM 2nd,Gerendasy DD,Sutcliffe JG,Cohen RW

更新日期：1996-11-29 00:00:00

abstract：:This study explored whether patients with Parkinson's disease alter the regulation of upright standing according to constraints imposed by the environmental context. The provision of context-dependent adaptations was inferred from the presence of adjustments to standing postural control that would serve to reduce fall...

journal_title：Neuroscience letters

authors： Brown LA,Doan JB,Whishaw IQ,Suchowersky O

更新日期：2007-05-18 00:00:00

abstract：:Occurrence of neurocalcin, a calcium-binding protein with three EF hand motifs, was examined immunohistochemically in the rat olfactory epithelium and vomeronasal organ epithelium. Immunoreactivity was detected in receptor cells in these epithelia. Immunoreactions were distributed in cytoplasm associated with outer mi...

journal_title：Neuroscience letters

authors： Iino S,Kobayashi S,Okazaki K,Hidaka H

更新日期：1995-05-19 00:00:00