Alterations in cortical thickness and neuronal density in the frontal cortex of Albert Einstein.

abstract：:Previous observations suggest a contribution of two APOE promoter polymorphisms (-219 G/T and -491 A/T) in dementia. From two independent populations of elderly (mean age of 84 and 85 years old, respectively), we observed that subjects bearing the -219T allele were at increased risk of dementia (OR = 1.9 (95% CI, 1.3-...

journal_title：Neuroscience letters

authors： Lambert JC,Berr C,Cottel D,Amouyel P,Helbecque N

更新日期：2004-07-22 00:00:00

abstract：:Cochlear hair cell loss results in the secondary loss of spiral ganglion cells (SGCs). The death of these SGCs is due to apoptosis. The E2F1-cyclin dependent kinase 1 (CDK1) pathway is believed to represent an important mechanism of neuronal cell death. However, the role of this pathway in spiral ganglion neuronal apo...

journal_title：Neuroscience letters

authors： Liu YY,Wang GP,Peng Z,Guo JY,Wu Q,Xie J,Gong SS

更新日期：2016-03-23 00:00:00

abstract：:Immunohistochemical fluorescent double labeling revealed the coexistence of galanin and substance P in nerve fibers in the mouse nasal mucosa. At the base of and in the epithelium, all galanin fibers also contained substance P, but around the blood vessels and glands, most of them did not. Since substance P fibers in ...

journal_title：Neuroscience letters

authors： Matsuda H,Tsukuda M,Kadota T,Kusunoki T,Kishida R

更新日期：1994-05-23 00:00:00

abstract：:Conduction velocities of antidromically evoked impulses along the goldfish Mauthner axon were found to be inversely correlated with body length. To test the hypothesis that such a relation is accompanied by a reduction in axonal diameter with increasing fish size, Mauthner axon diameters were measured. A parabolic rel...

journal_title：Neuroscience letters

authors： Funch PG,Kinsman SL,Faber DS,Koenig E,Zottoli SJ

更新日期：1981-12-11 00:00:00

abstract：:The present study tests the hypothesis that nitration is a potential mechanism of N-methyl-D-aspartate (NMDA) receptor modification, by assessing the effect of peroxynitrite in vitro on the glutamate and ion-channel sites of the NMDA receptor in the fetal guinea pig. Nitration of NMDA receptor subunits was confirmed b...

journal_title：Neuroscience letters

authors： Zanelli SA,Ashraf QM,Delivoria-Papadopoulos M,Mishra OP

更新日期：2000-12-15 00:00:00

abstract：:Rat neocortical slices maintained in Mg2(+)-free Krebs medium developed spontaneous paroxysmal discharges which were attenuated or suppressed by the gamma-aminobutyric acid-B (GABAB) receptor agonist baclofen, occasionally accompanied by a slight hyperpolarisation, and antagonised by the specific GABAB-receptor antago...

journal_title：Neuroscience letters

authors： Ong J,Kerr DI,Johnston GA,Hall RG

更新日期：1990-02-05 00:00:00

abstract：:Previous studies have extensively reported an advantage of females in empathy as compared with males. It remains to be clarified, however, whether these sex differences are associated with sex specific neural processes underlying empathic response to different intensity of emotional stimulus. The present study examine...

journal_title：Neuroscience letters

authors： Luo P,Zheng X,Chen X,Li Y,Wang J,Deng L,Zheng X

更新日期：2014-08-22 00:00:00

abstract：:We have studied the electrophysiological properties of enzymatically dissociated adult pigeon semicircular canal type I (chalice shaped) and type II (cylindrical shaped) hair cells using whole cell patch clamp techniques. Under current clamp conditions, type I hair cells often exhibit more hyperpolarized resting poten...

journal_title：Neuroscience letters

authors： Correia MJ,Lang DG

更新日期：1990-08-14 00:00:00

abstract：:Tenascin-R (TN-R) is a neural specific protein and an important molecule involved in inhibition of axonal regeneration after spinal cord injury (SCI). Here we report on rabbit-derived TN-R polyclonal antibody, which acts as a TN-R antagonist with high titer and high specificity, promoted neurite outgrowth and sproutin...

journal_title：Neuroscience letters

authors： You J,Hong SQ,Zhang MY,Zhao HL,Liu TZ,Zhou HL,Cai YQ,Xu ZM,Guo Y,Jiang XD,Xu RX

更新日期：2012-09-13 00:00:00

abstract：:A three-dimensional (3D) clinostat is a device for generating multidirectional G force, resulting in an environment with an average of 10(-3)G. We cultured human malignant glioma cell lines in a 3D-clinostat (CL group) and examined the growth properties and chemosensitivity of the cells compared to cells cultured unde...

journal_title：Neuroscience letters

authors： Takeda M,Magaki T,Okazaki T,Kawahara Y,Manabe T,Yuge L,Kurisu K

更新日期：2009-09-29 00:00:00

abstract：:The major human neurodegenerative diseases are characterised by ubiquitin-positive intraneuronal inclusions, however the precise nature of the ubiquitin modifications in these structures is unclear. Using a monoclonal antibody specific for Lys63-linked polyubiquitin we have performed the first immunohistochemical anal...

journal_title：Neuroscience letters

authors： Paine S,Bedford L,Thorpe JR,Mayer RJ,Cavey JR,Bajaj N,Sheppard PW,Lowe J,Layfield R

更新日期：2009-09-04 00:00:00

abstract：:Antidepressants such as tricyclic antidepressants, and serotonin noradrenaline reuptake inhibitors are a first-line treatment for neuropathic pain. Here, we aimed to determine the involvement of the spinal dopaminergic system in the antihyperalgesic effects of antidepressants in a rat model of neuropathic pain induced...

journal_title：Neuroscience letters

authors： Chen M,Hoshino H,Saito S,Yang Y,Obata H

更新日期：2017-05-10 00:00:00

abstract：:In 16 rats, the extensor digitorum longus (EDL) - a fast muscle - was grafted, complete with its innervation, into the bed of the (removed) soleus - a slow muscle. Following the transposition, performed on one side only, EDL recovered and showed the contraction time of the contralateral EDL that served as control. How...

journal_title：Neuroscience letters

authors： Gutmann E

更新日期：1976-07-01 00:00:00

abstract：:Cocaine-induced modifications of glutamatergic synaptic transmission in the mesolimbic system play a key role in adaptations that promote addictive behaviors. In particular, the activation of ionotropic glutamate N-methyl-D-aspartate receptor (NMDAR) in the ventral tegmental area (VTA) is critical for both cocaine-ind...

journal_title：Neuroscience letters

authors： Schumann J,Matzner H,Michaeli A,Yaka R

更新日期：2009-09-18 00:00:00

abstract：:In man, an anesthetic agent that induces surgical anesthesia with minimal influence on descending pyramidal tract activity remains to be found. Anesthesia with ketamine allows recording of stable compound muscle action potentials (CMAPs) to single transcranial magnetic stimulations of the motor cortex (CortStim) in mo...

journal_title：Neuroscience letters

authors： Kothbauer K,Schmid UD,Liechti S,Rösler KM

更新日期：1993-05-14 00:00:00

abstract：:We are constantly exposed to symbols such as traffic signs, emoticons in internet communication, or other abstract representations of objects as well as, of course, the written words. However, aside from the word reading, little is known about the way our brain responds when we read non-lexical iconic symbols. By usin...

journal_title：Neuroscience letters

authors： Shin YW,Kwon JS,Kwon KW,Gu BM,Song IC,Na DG,Park S

更新日期：2008-05-16 00:00:00

abstract：OBJECTIVES:To determine clinical characteristics and frequency of leucine-rich repeat kinase 2 gene (LRRK2) mutations in a cohort of patients with Parkinson's disease (PD) from Argentina. BACKGROUND:Variation in the LRRK2 gene represents the most common genetic determinant of PD, only few data are available from Latin...

journal_title：Neuroscience letters

authors： Gatto EM,Parisi V,Converso DP,Poderoso JJ,Carreras MC,Martí-Massó JF,Paisán-Ruiz C

更新日期：2013-03-14 00:00:00

abstract：:We carried out an immunohistochemical investigation of the spinal cords of 15 patients with sporadic amyotrophic lateral sclerosis (ALS), using antibodies to inducible nitric oxide synthase (iNOS) and nitrotyrosine; our purpose was to search for a possible role of increased oxidative damage in the motor system that ma...

journal_title：Neuroscience letters

authors： Sasaki S,Shibata N,Komori T,Iwata M

更新日期：2000-09-08 00:00:00

abstract：:Near-infrared spectroscopy (NIRS) is a non-invasive optical technique which has been successfully used to register substantial cerebral ischemia. There are indications that NIRS is sensible enough to detect also small metabolic changes during the performance of cognitive tasks. In the present study, two-channel NIRS o...

journal_title：Neuroscience letters

authors： Fallgatter AJ,Strik WK

更新日期：1997-02-21 00:00:00

abstract：:Lucifer Yellow (LY) selectively labels embryonic chick amacrine cells from days 11 until 14 in vivo. Its usefulness as an in vitro marker was investigated. In vivo labeling and subsequent culturing was not possible due to dye leakage. Neurons, however, could be labeled at various times in vitro. The number of neurons ...

journal_title：Neuroscience letters

authors： Zeevalk GD,Hyndman AG

更新日期：1986-03-14 00:00:00

abstract：:Several studies demonstrated that the overexpression of miR-124 in neural stem cells (NSCs) could lead the NSCs to differentiate into neurons and astrocytes, which may be important for functional recovery in spinal cord injury. The present study attempted to explore the potential repairing effect of the NSCs transfect...

journal_title：Neuroscience letters

authors： Xu W,Li P,Qin K,Wang X,Jiang X

更新日期：2012-10-31 00:00:00

abstract：:Several lines of evidence indicate that the histaminergic (HA) system is important for wakefulness and behavioral state regulation. We investigated the hypothesis that age-related changes in HA system occur which may be related to decreased alertness in aging. Although histidine decarboxylase mRNA levels did not chang...

journal_title：Neuroscience letters

authors： Terao A,Steininger TL,Morairty SR,Kilduff TS

更新日期：2004-01-23 00:00:00

abstract：:We have used light microscopic autoradiography to localize differentially Type 1 and 2 benzodiazepine receptors using pharmacologic and detergent treatment techniques. The triazolopyridazine CL218872 has preferential affinity for Type 1 receptors from which it displaces [3H]flunitrazepam selectivity. In biochemical ex...

journal_title：Neuroscience letters

authors： Lo MM,Niehoff DL,Kuhar MJ,Snyder SH

更新日期：1983-08-19 00:00:00

abstract：:Adaptation of the response to voluntary rapid arm flexion during 3 phases of the step cycle in humans are examined. The onset of arm movement was similar to the standing condition and was unaffected by the phase of the step cycle. The locomotor cycle in contrast was altered. These changes improved the stability of the...

journal_title：Neuroscience letters

authors： Patla AE

更新日期：1986-08-04 00:00:00

abstract：AIMS:To test the hypothesis that uridine 5'-triphosphate (UTP) had a protective effect on cerebral ischemia reperfusion (IR) injury in rats. METHODS:Ischemia was induced by intraluminal suture of middle cerebral artery occlusion (MCAO). UTP solution was delivered through an indwelling tail venous catheter via microinf...

journal_title：Neuroscience letters

authors： Tian ML,Zou Z,Yuan HB,Wang CC,Zhu QF,Xu HT,Gao X,Shi XY

更新日期：2009-11-06 00:00:00

abstract：:The streptozotocin (STZ)-induced diabetes model is widely used for the induction of neuropathy in the rat. In this model, diabetic animals often display chronic illness, which raises objections not only on ethical but also on scientific grounds. In this study, the investigators set out to determine the impact of bodyw...

journal_title：Neuroscience letters

authors： Hoybergs YM,Biermans RL,Meert TF

更新日期：2008-05-02 00:00:00

abstract：:In experiments using a synaptosomal preparation from the striatum and nucleus accumbens, somatostatin caused a dose-dependent increase in dopamine synthesis. This increase was additive with that produced by 8-BrcAMP but not with that produced by the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA), and was bl...

journal_title：Neuroscience letters

authors： Chowdhury M,Steardo L,Fillenz M

更新日期：1987-11-23 00:00:00

abstract：:Electrical stimulation of the primary auditory cortex (AI) of the cat was found to evoke EPSPs, IPSPs or EPSP-IPSP sequences in colliculogeniculate (CG) neurons in the inferior colliculus (IC) which responded antidromically to stimulation of the medial geniculate nucleus. The CG neurons responding to the AI stimulatio...

journal_title：Neuroscience letters

authors： Mitani A,Shimokouchi M,Nomura S

更新日期：1983-12-02 00:00:00

abstract：:A free radical scavenger edaravone is clinically used in Japan for acute stroke, and several basic researches have carefully examined the mechanisms of edaravone's protective effects. However, its actions on pro-inflammatory responses under stroke are still understudied. In this study, we subjected adult male Sprague-...

journal_title：Neuroscience letters

authors： Fujiwara N,Som AT,Pham LD,Lee BJ,Mandeville ET,Lo EH,Arai K

更新日期：2016-10-28 00:00:00

abstract：:A study was carried out to determine at what stage of development the adult pattern of primary afferent projections to the substantia gelatinosa (SG) is first established. Horseradish peroxidase conjugated wheat-germ agglutinin (WGA-HRP) was applied to cut ends of sciatic nerves at mid-thigh level in adult and neonata...

journal_title：Neuroscience letters

authors： Fitzgerald M,Swett J

更新日期：1983-12-30 00:00:00