当前位置： SCI文献检索 > NEUROSCIENCE LETTERS期刊下所有文献 > Uridine 5'-triphosphate (UTP) protects against cerebral ischemia reperfusion injury in rats.

Uridine 5'-triphosphate (UTP) protects against cerebral ischemia reperfusion injury in rats.

Abstract：

AIMS:To test the hypothesis that uridine 5'-triphosphate (UTP) had a protective effect on cerebral ischemia reperfusion (IR) injury in rats. METHODS:Ischemia was induced by intraluminal suture of middle cerebral artery occlusion (MCAO). UTP solution was delivered through an indwelling tail venous catheter via microinfusion pump 30 min after the occlusion of MCA at a rate of 0.5 ml/100 g/min. Neurological deficit score (NDS) and brain water content were determined 24 h after reperfusion. Infarct volume was determined by 2,3,5-triphenyl-tetrazolium chloride (TTC) staining and magnetic resonance imaging (MRI), and nerve cell death was studied under an electron microscope. RESULTS:There was a dose-dependent relationship among 10, 30 and 90 microg/kg UTP. The 90 microg/kg UTP had the best protective effect among the 3 groups. We compared 90 microg/kg UTP group with normal saline group and found that UTP had a protective effect on cerebral IR by the results of TTC staining (15.9% vs 30.5%, P<0.01). MRI at 6, 30 and 54 h after reperfusion showed smaller infarct volume in 90 microg/kg group compared with 0 microg/kg group (283.5, 352.1, 367.45 mm(3) vs 401.36, 576.75 and 677.11 mm(3), respectively), and electron microscope showed less nerve cell death in 90 microg/kg group compared with 0 microg/kg group. CONCLUSION:UTP has a dose-dependent protective effect on cerebral IR.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Tian ML,Zou Z,Yuan HB,Wang CC,Zhu QF,Xu HT,Gao X,Shi XY

doi

10.1016/j.neulet.2009.08.076

subject

Has Abstract

pub_date

2009-11-06 00:00:00

pages

55-60

issue

1

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(09)01180-X

journal_volume

465

pub_type

杂志文章

相关文献

NEUROSCIENCE LETTERS文献大全
  • Cerebrospinal fluid vasopressin and oxytocin: evidence for an osmotic response.

    abstract：:A push-pull perfusion technique was used to sample third ventricular cerebrospinal fluid (CSF) in the conscious rat. Ventricular perfusate contained significant quantities of vasopressin and oxytocin, 13.1 and 4.5 pg/ml, respectively. Vasopressin and oxytocin levels were stable over a 3 h perfusion period. High sodium...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(82)90329-9

    authors： Barnard RR Jr,Morris M

    更新日期：1982-04-26 00:00:00

  • Early induction of c-Myc is associated with neuronal cell death.

    abstract：:Neuronal cell cycle activation has been implicated in neurodegenerative diseases such as Alzheimer's disease, while the initiating mechanism of cell cycle activation remains to be determined. Interestingly, our previous studies have shown that cell cycle activation by c-Myc (Myc) leads to neuronal cell death which sug...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2011.10.004

    authors： Lee HP,Kudo W,Zhu X,Smith MA,Lee HG

    更新日期：2011-11-14 00:00:00

  • gamma-Aminobutyric acidB receptors in the rat brain: quantitative autoradiographic localization using [3H](-)-baclofen.

    abstract：:The light microscopic localization of gamma-aminobutyric acidB (GABAB) receptors in the rat brain has been accomplished using in vitro autoradiography with [3H]baclofen as a ligand. Initial biochemical studies indicated this compound specifically bound to slide-mounted tissue sections with high affinity in a saturable...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(85)90126-0

    authors： Gehlert DR,Yamamura HI,Wamsley JK

    更新日期：1985-05-14 00:00:00

  • Decision-making to initiate voluntary movements in the rat is altered during deprivation of rapid eye movement sleep.

    abstract：:Eight male rats were deprived of rapid eye movement (REM) sleep for 6 days by means of a cuff pedestal which makes it possible to use the animal as its own control. In order to obtain access to food, the rat had to jump from its pedestal to a strip of wire mesh suspended from the ceiling of the deprivation chamber. Th...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(86)90011-x

    authors： Elomaa E,Johansson GG

    更新日期：1986-01-02 00:00:00

  • Nicotinamide-N-methyltransferase is higher in the lumbar cerebrospinal fluid of patients with Parkinson's disease.

    abstract：:Parkinson's disease (PD) may be initiated or precipitated by endogenous toxins with a structure similar to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in genetically-predisposed individuals. Nicotinamide N-methyltransferase (NNMT) catalyzes N-methylation of nicotinamide and other pyridines to form pyridinium ions. Th...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(00)01723-7

    authors： Aoyama K,Matsubara K,Kondo M,Murakawa Y,Suno M,Yamashita K,Yamaguchi S,Kobayashi S

    更新日期：2001-01-26 00:00:00

  • Circadian rhythm in metabolic activity of suprachiasmatic, supraoptic and raphe nuclei.

    abstract：:Previous studies using 2-deoxyglucose (2-DG) autoradiography have demonstrated that the suprachiasmatic nucleus (SCN) of the hypothalamus, a putative neural circadian pacemaker, displays circadian rhythmicity in its metabolic activity. In the present study, we show that distinct circadian variations in 2-DG uptake occ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(85)90161-2

    authors： Rosenwasser AM,Trubowitsch G,Adler NT

    更新日期：1985-07-31 00:00:00

  • Modulations on cortical oscillations by subthalamic deep brain stimulation in patients with Parkinson disease: A MEG study.

    abstract：OBJECTIVE:The study aimed to explore the modification to cortical oscillations of Parkinson disease (PD) patients by subthalamic nucleus deep brain stimulation (STN DBS). METHODS:With Magnetoencephalogram (MEG) detection, we examined the changes in absolute power spectrum of cortical oscillations in the PD patients wi...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2016.11.009

    authors： Cao CY,Zeng K,Li DY,Zhan SK,Li XL,Sun BM

    更新日期：2017-01-01 00:00:00

  • Interactions between emotional stress due to fear and hypovolemic stimuli in the control of vasopressin secretion in rats.

    abstract：:Interactions between emotional stress due to fear and hypovolemic stimuli on vasopressin secretion were studied in rats. Intraperitoneally injected dextran did not significantly change plasma osmolality and arterial blood pressure but increased blood hemoglobin and plasma vasopressin level. An i.v. infused physiologic...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(90)90034-7

    authors： Onaka T,Yagi K

    更新日期：1990-12-11 00:00:00

  • Impaired neurotransmitter systems by Abeta amyloidosis in APPsw transgenic mice overexpressing amyloid beta protein precursor.

    abstract：:APPsw transgenic mice showing substantial features of brain Abeta amyloidosis such as senile plaques and behavioral abnormalities were examined by immunostaining to determine whether Abeta deposits could induce the subsequent disturbance of neurotransmitter systems including somatostatin, substance P and choline acety...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(00)01443-9

    authors： Tomidokoro Y,Harigaya Y,Matsubara E,Ikeda M,Kawarabayashi T,Okamoto K,Shoji M

    更新日期：2000-10-13 00:00:00

  • Acrylamide decreased dopamine levels and increased 3-nitrotyrosine (3-NT) levels in PC 12 cells.

    abstract：:Acrylamide is a chemical known to produce neurotoxicity in animals, as well as in humans. The mechanism of acrylamide-induced neurotoxicity is not fully known. However, recent studies have revealed that acrylamide affects the dopaminergic system. Therefore, the aim of this study was to investigate the effect of acryla...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2009.04.016

    authors： Tareke E,Lyn-Cook BD,Duhart H,Newport G,Ali S

    更新日期：2009-07-17 00:00:00

  • Are stance ankle plantar flexor muscles necessary to generate propulsive force during human gait initiation?

    abstract：:The study examined whether the generation of the forward propulsive force (PF) during gait initiation resulted mainly from the electromyogram activity of stance ankle plantar flexor muscles (APF) which 'push' on the ground as is generally claimed in the literature. Six unilateral above-knee amputees performed a specif...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(02)00255-0

    authors： Michel V,Do MC

    更新日期：2002-06-07 00:00:00

  • Integration of heard and seen speech: a factor in learning disabilities in children.

    abstract：:Normal-learning children (NL) and children with learning disabilities (LD) reported their perceptions of unisensory (auditory or visual), concordant audiovisual (e.g. visual /apa/ and auditory /apa/) and conflicting (e.g. visual /aka/ and auditory /apa/) speech stimuli in quiet and noise (0 dB and -12 dB signal-to-noi...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(03)00971-6

    authors： Hayes EA,Tiippana K,Nicol TG,Sams M,Kraus N

    更新日期：2003-11-06 00:00:00

  • Feeding the developing brain: Juvenile rats fed diet rich in prebiotics and bioactive milk fractions exhibit reduced anxiety-related behavior and modified gene expression in emotion circuits.

    abstract：:Early life nutrition is critical for brain development. Dietary prebiotics and bioactive milk fractions support brain development by increasing plasticity and altering activity in brain regions important for cognition and emotion regulation, perhaps through the gut-microbiome-brain axis. Here we examined the impact of...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2018.01.052

    authors： Mika A,Gaffney M,Roller R,Hills A,Bouchet CA,Hulen KA,Thompson RS,Chichlowski M,Berg BM,Fleshner M

    更新日期：2018-06-11 00:00:00

  • Pinprick hypo- and hyperalgesia in diabetic rats: Can diet content affect experimental outcome?

    abstract：:Existing literature concerning the effect of experimentally-induced diabetes on pain thresholds in rodent models remains controversial. In this work, we describe a phenotypical switch from streptozotocin-induced pinprick hypoalgesia to hyperalgesia observed in the same laboratory, in the same strain of rats, obtained ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2018.02.054

    authors： Yadlapalli JSK,Dogra N,Walbaum AW,Prather PL,Crooks PA,Dobretsov M

    更新日期：2018-04-23 00:00:00

  • Mice and rats differ with respect to activity-dependent slowing of conduction velocity in the saphenous peripheral nerve.

    abstract：:We assess in mice, the electrophysiological criteria developed in humans and rats in vivo for unmyelinated (C) fibre differentiation into sub-classes, derived from the activity-induced latency increase ("slowing") in response to electrical stimulation during 6 min at 0.25 Hz followed by 3 min at 2 Hz. Fibres are consi...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2015.02.057

    authors： Hoffmann T,De Col R,Messlinger K,Reeh PW,Weidner C

    更新日期：2015-04-10 00:00:00

  • Dopamine modulation of glutamate metabotropic receptors in conditioned reaction of sensory motor cortex neurons of the cat.

    abstract：:The dopamine modulation of microiontophoretic application of antagonists of glutamate metabotropic synaptic transmission was studied in the sensory motor cortex of awake cats during instrumental conditioned reflex. The substances depressed the background and intensity of evoked impulse activity of pyramidal neurons of...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2003.11.039

    authors： Storozhuk VM,Khorevin VI,Rozumna NM,Villa AE,Tetko IV

    更新日期：2004-02-12 00:00:00

  • Altered vesicular glutamate transporter expression in human temporal lobe epilepsy with hippocampal sclerosis.

    abstract：:Vesicular glutamate transporters (VGLUTs) are responsible for loading glutamate into synaptic vesicles. Altered VGLUT protein expression has been suggested to affect quantal size and glutamate release under both physiological and pathological conditions. In this study, we investigated mRNA and protein expression level...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2015.01.080

    authors： Van Liefferinge J,Jensen CJ,Albertini G,Bentea E,Demuyser T,Merckx E,Aronica E,Smolders I,Massie A

    更新日期：2015-03-17 00:00:00

  • Pragmatic inferences modulate N400 during sentence comprehension: evidence from picture-sentence verification.

    abstract：:The present study examines the online realization of pragmatic meaning using event-related potentials (ERPs). Participants read sentences including the English quantifier some, which has both a semantic meaning (at least one) and a pragmatic meaning (not all). Unlike previous ERP studies of this phenomenon, sentences ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2012.11.044

    authors： Hunt L 3rd,Politzer-Ahles S,Gibson L,Minai U,Fiorentino R

    更新日期：2013-02-08 00:00:00

  • Insulin-like growth factor 1 (IGF1) and its active peptide (1-3)IGF1 enhance the expression of synaptic markers in neuronal circuits through different cellular mechanisms.

    abstract：:Insulin-like growth factor-1 (IGF1) and its active peptide (1-3)IGF1 modulate brain growth and plasticity and are candidate molecules for treatment of brain disorders. IGF1 N-terminal portion is naturally cleaved to generate the tri-peptide (1-3)IGF1 (glycine-praline-glutamate). IGF1 and (1-3)IGF have been proposed as...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2012.05.029

    authors： Corvin AP,Molinos I,Little G,Donohoe G,Gill M,Morris DW,Tropea D

    更新日期：2012-06-27 00:00:00

  • Effects of unilateral lesion of the nucleus basalis magnocellularis on carbachol- and serotonin-stimulated [3H]inositolmonophosphate accumulation in rat fronto-parietal cortex.

    abstract：:We examined the effects of ibotenic acid induced unilateral lesion of the nucleus basalis magnocellularis (nBM) on carbachol- and serotonin-stimulated phosphoinositide (PI) breakdown in miniprisms obtained from rat fronto-parietal cortex 1 week following the lesion. Lesion-side muscarinic and serotoninergic receptor r...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(95)11658-j

    authors： Erfurth A,Holmes TC

    更新日期：1995-06-23 00:00:00

  • Prolonged exposure to N-methyl-D-aspartate increases intracellular and secreted somatostatin in rat cortical cells.

    abstract：:Somatostatin (SRIF) release from fetal rat cortical cells was stimulated by exposure to 10(-5) M N-methyl-D-aspartate (NMDA) (250 +/- 20% of basal at 96 h). A similar but much less potent effect was seen with kainate (KA) but not with quisqualate (Q) which inhibited SRIF release (KA 150 +/- 13%, Q 65 +/- 18% of basal ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(91)90476-a

    authors： Ham J,Rickards C,Scanlon M

    更新日期：1991-08-19 00:00:00

  • Hypoxia and reoxygenation increased BACE1 mRNA and protein levels in human neuroblastoma SH-SY5Y cells.

    abstract：:Ischemic cerebrovascular diseases, usually involved in hypoxia and reoxygenation, have been reported to increase the risk of dementia such as Alzheimer's disease (AD). beta-site amyloid protein precursor (APP)-cleaving enzymes (BACE1) have been identified to participate in the secretion of beta-amyloid peptides (Abeta...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2006.07.013

    authors： Xue S,Jia L,Jia J

    更新日期：2006-09-25 00:00:00

  • Overeating, alcohol and sucrose consumption decrease in CB1 receptor deleted mice.

    abstract：:Administration of the cannabinoid CB1 receptor antagonist SR141716 (3-10 mg/kg i.p.) abolished neuropeptide Y-induced overeating and significantly reduced ethanol and sucrose intake in CB1 wild-type (+/+) mice. In CB1 receptor knockout (-/-) mice, neuropeptide Y totally lost its capacity to increase food consumption. ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(03)00397-5

    authors： Poncelet M,Maruani J,Calassi R,Soubrié P

    更新日期：2003-06-12 00:00:00

  • Somatostatin-like immunoreactive neurons in the hippocampus: an immunocytochemical study in the rat.

    abstract：:Using antibodies to somatostatin in combination with the avidin-biotin immunohistochemical method, the laminar distribution and morphology of somatostatin-like (SOM-L) immunoreactive cells have been studied in the hippocampal formation of the rat. SOM-L positive cells are present throughout the longitudinal axis of th...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(82)90185-9

    authors： Köhler C,Chan-Palay V

    更新日期：1982-12-31 00:00:00

  • A Parkinson's disease gene, DJ-1, regulates astrogliosis through STAT3.

    abstract：:In the injured brain, astrocytes become activated and increase GFAP expression; a phenomenon termed as astrogliosis. Previously, we have reported that DJ-1, a Parkinson's disease gene, positively regulates astrogliosis in the injured brain. Moreover, STAT3 is known to play a key role in the regulation of astrogliosis....

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2018.08.025

    authors： Choi DJ,Kwon JK,Joe EH

    更新日期：2018-10-15 00:00:00

  • N-methyl-D-aspartate receptor and L-type voltage-gated Ca2+ channel activation mediate proline-rich tyrosine kinase 2 phosphorylation during cerebral ischemia in rats.

    abstract：:Cerebral ischemia induces rapid efflux of glutamate into the extracellular space contributing to excessive activation of glutamate receptors in postsynaptic cells, particularly N-methyl-D-aspartate (NMDA) receptors, which triggers the neuron lesion through calcium overload. Our studies indicated that cerebral ischemia...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2003.10.076

    authors： Guo J,Meng F,Fu X,Song B,Yan X,Zhang G

    更新日期：2004-01-30 00:00:00

  • Neural correlates of transmeatal cochlear laser (TCL) stimulation in healthy human subjects.

    abstract：:Transmeatal cochlear laser (TCL) treatment has recently been proposed as a therapeutic procedure for cochlear dysfunction such as chronic cochlear tinnitus or sensorineural hearing loss. The aim of this study was to investigate whether TLC has any influence on the central nervous system using functional MRI with healt...

    journal_title：Neuroscience letters

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.neulet.2006.08.049

    authors： Siedentopf CM,Ischebeck A,Haala IA,Mottaghy FM,Schikora D,Verius M,Koppelstaetter F,Buchberger W,Schlager A,Felber SR,Golaszewski SM

    更新日期：2007-01-16 00:00:00

  • Immunohistochemical study of advanced glycation end products in aging and Alzheimer's disease brain.

    abstract：:Advanced glycation end products (AGEs) in the brain were immunohistochemically examined in Alzheimer's disease (AD) and aging using anti-AGE antibody recognizing mainly carboxymethyllysine. AGE positive staining diffusely located in the neuronal perikarya of hippocampus and parahippocampus in AD and aged brains withou...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(96)13275-4

    authors： Takedo A,Yasuda T,Miyata T,Mizuno K,Li M,Yoneyama S,Horie K,Maeda K,Sobue G

    更新日期：1996-12-27 00:00:00

  • Hypothalamic neurons projecting to the rat caudal medulla oblongata, examined by immunoperoxidase staining of retrogradely transported horseradish peroxidase.

    abstract：:Horseradish peroxidase (HRP), injected into the rat caudal medulla oblongata, was detected by immunoperoxidase staining in 120 microns frozen sections, allowing examination of both the distribution and morphology of transporting neurons. In the hypothalamus, several groups of HRP-labeled neurons could be distinguished...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(80)90270-0

    authors： Sofroniew MV,Schrell U

    更新日期：1980-10-02 00:00:00

  • Regional and cellular distribution of bleomycin hydrolase mRNA in human brain: comparison between Alzheimer's diseased and control brains.

    abstract：:Genetic polymorphism of human bleomycin hydrolase (hBH) has been reported to be associated with the risk of sporadic Alzheimer's disease (AD). The regional and cellular distribution of mRNA encoding hBH in the brain from controls and patients with AD was examined using in situ hybridization. A hybridization signal, in...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(00)00802-8

    authors： Malherbe P,Faull RL,Richards JG

    更新日期：2000-03-03 00:00:00