Freezing of gait is associated with cognitive impairment in patients with Parkinson disease.

abstract：:Flupirtine is a centrally acting nonopioid analgesic with muscle-relaxant properties. Flupirtine has been found to activate inwardly rectifying potassium conductances and hence to indirectly inhibit the activation of NMDA receptors. NMDA receptor activation is crucial for the induction of long-term potentiation (LTP) ...

journal_title：Neuroscience letters

authors： Azad SC,Eder M,Simon W,Hapfelmeier G,Dodt HU,Zieglgänsberger W,Rammes G

更新日期：2004-11-11 00:00:00

abstract：:N-Methyl-d-Aspartate receptors (NMDARs) are present in both pyramidal neurons and interneurons of the hippocampus. These receptors play a key role in the structural plasticity of excitatory neurons, but to date little is known about their influence on the remodeling of interneurons. Among hippocampal interneurons, the...

journal_title：Neuroscience letters

authors： Pérez-Rando M,Castillo-Gómez E,Bellés M,Carceller H,Nácher J

更新日期：2017-09-29 00:00:00

abstract：:Recently, the gene called DAAO was reported to be associated with schizophrenia in the French Canadian populations. Here, we report a result obtained in the study of our large collection of 547 schizophrenia cases and 536 controls in the Chinese population. Six single-nucleotide polymorphisms (SNPs) were genotyped at ...

journal_title：Neuroscience letters

authors： Liu X,He G,Wang X,Chen Q,Qian X,Lin W,Li D,Gu N,Feng G,He L

更新日期：2004-10-21 00:00:00

abstract：:Muscarinic cholinoreceptors regulate the neurosecretion process in vertebrate neuromuscular junctions. The diversity of muscarinic effects on acetylcholine (ACh) secretion may be attributed to the different muscarinic subtypes involved in this process. In the present study, the location of five muscarinic receptor sub...

journal_title：Neuroscience letters

authors： Tsentsevitsky AN,Kovyazina IV,Nurullin LF,Nikolsky EE

更新日期：2017-05-10 00:00:00

abstract：:Anatomical relationships of hypothalamic cocaine- and amphetamine-regulated transcript (CART) with other hypothalamic neuropeptides were examined by using in situ hybridization histochemistry and immunohistochemistry. CART mRNA was found in various regions in rat hypothalamus, including the periventricular nucleus, pa...

journal_title：Neuroscience letters

authors： Li HY,Hwang HW,Hu YH

更新日期：2002-05-03 00:00:00

abstract：:Occurrence of neurocalcin, a calcium-binding protein with three EF hand motifs, was examined immunohistochemically in the rat olfactory epithelium and vomeronasal organ epithelium. Immunoreactivity was detected in receptor cells in these epithelia. Immunoreactions were distributed in cytoplasm associated with outer mi...

journal_title：Neuroscience letters

authors： Iino S,Kobayashi S,Okazaki K,Hidaka H

更新日期：1995-05-19 00:00:00

abstract：:Cuneo-thalamic projection cells in the rat were identified after injection of horseradish peroxidase into the contralateral thalamic nucleus ventralis posterolateralis. By light microscopy, labelled cells were 16-20 microm in diameter, round or oval in shape, distributed throughout the cuneate nucleus and concentrated...

journal_title：Neuroscience letters

authors： Tan CK,Lieberman AR

更新日期：1978-11-01 00:00:00

abstract：:Huntingtin-associated protein 1 (HAP1) interacts with the product of the Huntington's disease gene. To investigate the function of Hap1 in development and in the adult mouse, we have examined the expression of Hap1 by northern analysis and in situ hybridization histochemistry. Hap1 expression is first detected in the ...

journal_title：Neuroscience letters

authors： Dragatsis I,Dietrich P,Zeitlin S

更新日期：2000-03-17 00:00:00

abstract：:In this study, we investigated the eye movement and postural control performance in dyslexic children while reading text and performing Landolt reading when sitting and standing. Fifteen dyslexic and 15 non-dyslexic children were asked to sit in a chair while the eye movements were recorded, and were then asked to sta...

journal_title：Neuroscience letters

authors： Razuk M,Barela JA,Peyre H,Gerard CL,Bucci MP

更新日期：2018-11-01 00:00:00

abstract：:The effects of free fatty acids (FFAs) on growth hormone releasing hormone (GHRH) secretion by fetal rat cortical and hypothalamic neurons in monolayer culture have been investigated. Treatment with caprylic or oleic acids for 90 min, induced a dose-dependent increase in GHRH secretion. The stimulatory effect of capry...

journal_title：Neuroscience letters

authors： Señaris RM,Lewis MD,Lago F,Dominguez F,Scanlon MF,Dieguez C

更新日期：1992-01-20 00:00:00

abstract：:Mutations in the hairless (hr) gene of mice result in hair follicle and other epithelial defects. The hr gene is expressed at high levels in the brain where it probably participates in the survival and maintenance of some neuronal populations, but whether it also supports glial populations of the central nervous syste...

journal_title：Neuroscience letters

authors： San Jose I,García-Atares N,Pelaez B,Cabo R,Esteban I,Vega JA,Represa J

更新日期：2001-08-24 00:00:00

abstract：:Sleep fragmentation due to intermittent nocturnal arousal resulting in a reduction of total sleep time and sleep efficiency is a common symptom among people with Alzheimer's disease (AD) and elderly people with normal cognitive function. Although epidemiological studies have indicated an association between sleep frag...

journal_title：Neuroscience letters

authors： Minakawa EN,Miyazaki K,Maruo K,Yagihara H,Fujita H,Wada K,Nagai Y

更新日期：2017-07-13 00:00:00

abstract：:Strychnine-sensitive glycine-activated currents and gamma-aminobutyric acid (GABA)-activated currents were compared in two types of neurons acutely isolated from striatal slices by vibrodissociation: large cells, presumably cholinergic giant aspiny neurons (GAN) and medium sized cells, presumed medium spiny neurons (M...

journal_title：Neuroscience letters

authors： Sergeeva OA

更新日期：1998-02-27 00:00:00

abstract：:A peptide consisting of residues 25-35 of the amyloid beta protein was applied to single neurons while monitoring membrane current by whole cell voltage clamp recording. Within minutes of direct exposure of a neuron to the amyloid beta peptide, a paroxysmal increase in neuronal membrane conductance was observed. This ...

journal_title：Neuroscience letters

authors： Simmons MA,Schneider CR

更新日期：1993-02-19 00:00:00

abstract：:We evaluated the modulation of baroreceptor reflex (BRR) response by locus coeruleus (LC) in adult, male Sprague-Dawley rats anesthetized with urethane (1.5 g/kg, i.p.). Under an electrical stimulation condition that did not appreciably alter the basal systemic arterial pressure and heart rate, the LC significantly su...

journal_title：Neuroscience letters

authors： Chan JY,Jang SF,Chan SH

更新日期：1992-09-14 00:00:00

abstract：:It is uncertain if the several brain areas in response to presemantic picture processing are functionally homogeneous. Subjects were asked to discriminate visual stimulus pairs and event-related potentials (ERPs) were recorded from the scalp. A line-drawing picture (S1) was followed by another stimulus (S2) 600 ms lat...

journal_title：Neuroscience letters

authors： Wang Y,Tang X,Kong J,Zhuang D,Li S

更新日期：1998-12-04 00:00:00

abstract：:Using a specific radioimmunoassay (RIA), we have quantitated the hypothalamic and extrahypothalamic distribution of vasoactive intestinal polypeptide (VIP) in the rat brain. Highest concentrations of VIP were found in cerebral cortex, suprachiasmatic nucleus, and medial amygdaloid nucleus. Lower concentrations were fo...

journal_title：Neuroscience letters

authors： Samson WK,Said SI,McCann SM

更新日期：1979-05-01 00:00:00

abstract：:Alpha-2 macroglobulin (A2M) is a component of Lewy bodies, a hallmark of Parkinson's disease (PD). In 159 PD patients and 190 normal controls, we studied two A2M polymorphisms by the polymerase chain reaction-restriction fragment length polymorphism method: a five-nucleotide deletion at the 5' splice site of exon 18; ...

journal_title：Neuroscience letters

authors： Nicoletti G,Annesi G,Tomaino C,Spadafora P,Pasqua AA,Annesi F,Serra P,Caracciolo M,Messina D,Zappia M,Quattrone A

更新日期：2002-08-02 00:00:00

abstract：:The effects of glutamate uptake inhibitors on the L-glutamate-induced increase in intracellular calcium concentrations were assessed in rat primary cortical cultures. The glutamate (10 microM)-induced rise in intracellular calcium concentrations was strongly and dose dependently increased and prolonged by simultaneous...

journal_title：Neuroscience letters

authors： Freund WD,Grieshop B,Neumann U,Reddig S

更新日期：1995-03-16 00:00:00

abstract：:Experiments using functional magnetic resonance imaging (fMRI) play a fundamental role in affective neuroscience. When placed in an MR scanner, some volunteers feel safe and relaxed in this situation, while others experience uneasiness and fear. Little is known about the basis and consequences of such inter-individual...

journal_title：Neuroscience letters

authors： Mutschler I,Wieckhorst B,Meyer AH,Schweizer T,Klarhöfer M,Wilhelm FH,Seifritz E,Ball T

更新日期：2014-11-07 00:00:00

abstract：:P2X receptors (P2XRs) are a family of ATP-gated ionic channels that are expressed in numerous excitable and non-excitable cells. Despite the great advance on the structure and function of these receptors in the last decades, there is still lack of specific and potent antagonists for P2XRs subtypes, especially for the ...

journal_title：Neuroscience letters

authors： Coddou C,Sandoval R,Hevia MJ,Stojilkovic SS

更新日期：2019-01-18 00:00:00

abstract：:The cells of the entorhinal cortex receive a dense innervation of serotonergic fibres from the Raphe nuclei and express a high density of 5-hydroxytryptamine 1A (5-HT1A) receptors. We investigated the effects of serotonin on excitatory synaptic transmission in principal cells from entorhinal cortex layers II and III w...

journal_title：Neuroscience letters

authors： Schmitz D,Empson RM,Gloveli T,Heinemann U

更新日期：1995-04-28 00:00:00

abstract：:The effect of antagonists on N-methyl-D-aspartate (NMDA)-induced response was investigated in isolated nucleus tractus solitarii (NTS) neurons freshly isolated from the rat using a conventional pathclamp technique. The NMDA-induced inward current consisted of an initial peak followed by a steady-state component. The c...

journal_title：Neuroscience letters

authors： Nakagawa T,Shirasaki T,Tateishi N,Murase K,Akaike N

更新日期：1990-05-31 00:00:00

abstract：:The involvement of glutamate receptors in the central transmission of somatosympathetic reflexes was studied by examining, in anesthetized rats, the effects of MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist, and CNQX, a non-NMDA receptor antagonist, on two reflex components, the A- and C-reflexes evoked in...

journal_title：Neuroscience letters

authors： Nagata O,Li WM,Sato A

更新日期：1995-12-08 00:00:00

abstract：:We performed an experiment in which we challenged postural stability in 12 healthy subjects by providing artificial delayed visual feedback. A monitor at eye-height presented subjects with a visual representation of the location of their center-of-pressure (COP) and they were instructed to position their COP as accura...

journal_title：Neuroscience letters

authors： van den Heuvel MR,Balasubramaniam R,Daffertshofer A,Longtin A,Beek PJ

更新日期：2009-03-06 00:00:00

abstract：:Murine Prickle1 and Prickle2 belong to the planar cell polarity genes. Prickle2 but not Prickle1 gene expression was induced in C1300 neuroblastoma cells during neurite-like process formation induced by retinoic acid (RA). Over-expression of Prickle1 or Prickle2 in C1300 cells induced striking neurite-like process for...

journal_title：Neuroscience letters

authors： Fujimura L,Watanabe-Takano H,Sato Y,Tokuhisa T,Hatano M

更新日期：2009-12-18 00:00:00

abstract：:We describe a novel and powerful extracellular method for the staining of a single neuron identified by electrophysiological criteria. This single-unit technique involves the use of glass micro-electrodes (tip diameter: 1.5-2.5 microns) filled with a saline solution (NaCl; 0.5 M) containing 1.5% of biocytin or Neurobi...

journal_title：Neuroscience letters

authors： Pinault D

更新日期：1994-04-11 00:00:00

abstract：:Transient cognitive and behavioral stabilization of patients with Alzheimer's disease (AD) is the main goal of acetylcholinesterase inhibitor (AChEI) therapy. Response to treatment is variable and it is usually assessed clinically via neuropsychological scales. Functional neuroimaging could ideally permit the objectiv...

journal_title：Neuroscience letters

authors： Ferreri F,Pasqualetti P,Määttä S,Ponzo D,Guerra A,Bressi F,Chiovenda P,Del Duca M,Giambattistelli F,Ursini F,Tombini M,Vernieri F,Rossini PM

更新日期：2011-04-01 00:00:00

abstract：:Intracellular recordings were used to study the contribution of nicotinic and P2X receptors to synaptic transmission to morphologically identified myenteric neurons of guinea-pig ileum. Hexamethonium (100 microM) abolished fast excitatory synaptic potentials (EPSPs) in all orally projecting neurons, but fast EPSPs in ...

journal_title：Neuroscience letters

authors： Johnson PJ,Shum OR,Thornton PD,Bornstein JC

更新日期：1999-05-14 00:00:00

abstract：:Spontaneous openings of acetylcholine receptor channels were investigated using Xenopus myotomal muscle cells in culture and patch clamp recording methods. Two classes of channels with conductances close to 40 and 60 pS and reversal potentials near 0 mV were found to open in the absence of agonist. The open time of th...

journal_title：Neuroscience letters

authors： Rojas L,Zuazaga C

更新日期：1991-04-01 00:00:00