Abstract:
:The effect of antagonists on N-methyl-D-aspartate (NMDA)-induced response was investigated in isolated nucleus tractus solitarii (NTS) neurons freshly isolated from the rat using a conventional pathclamp technique. The NMDA-induced inward current consisted of an initial peak followed by a steady-state component. The competitive antagonists of NMDA receptor, D-2-amino-5-phosphonovalerate (APV), D-2-amino-4-phosphonoheptanoate (APH) and 3-3(2-carboxypiperazine-4-yl)propyl-1-phosphate (CPP), selectively suppressed the initial peak of NMDA-induced current more than the steady-state component at low concentrations. The non-competitive antagonists, MK-801, ketamine, Zn2+ and Mg2+, equally blocked both peak and steady-state components.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Nakagawa T,Shirasaki T,Tateishi N,Murase K,Akaike Ndoi
10.1016/0304-3940(90)90298-nsubject
Has Abstractpub_date
1990-05-31 00:00:00pages
169-74issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(90)90298-Njournal_volume
113pub_type
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