Abstract:
:Patients with schizophrenia are especially impaired in the detection of spatial location if the briefly presented target stimulus is followed by a mask in a close temporal proximity (target location backward masking (BM) paradigm). It has been suggested that this phenomenon is related to the impairment of low spatial and high temporal frequency-sensitive transient (magnocellular) visual channels. To test this hypothesis, we measured target location BM and visual contrast sensitivity (CS) in clinically remitted patients with schizophrenia. In the BM task, subjects were asked to indicate the position of letters appearing at four possible spatial locations. In the CS test, a two-alternative forced choice method was used to measure the minimal contrast level required for the detection of horizontal gratings set at low spatial and high temporal frequencies (0.5 cycle/degree and 8 Hz, respectively). We found that the schizophrenia patients with normal CSs (spared transient channel functions) showed a marked deficit in the target location BM task. This suggests that the abnormality of subcortical transient channels does not explain some visual information processing dysfunctions in schizophrenia. Instead, deficient cortical interactions of rapidly changing environmental signals may be involved.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Kéri S,Antal A,Szekeres G,Benedek G,Janka Zdoi
10.1016/s0304-3940(00)01473-7keywords:
subject
Has Abstractpub_date
2000-10-20 00:00:00pages
69-71issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(00)01473-7journal_volume
293pub_type
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