Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animals.

Abstract:

:DJ-1, the causative gene of a familial form of Parkinson's disease (PD), has been reported undergo oxidation preferentially at the 106th cysteine residue (Cys-106) under oxidative stress. Recently, it has been found that the levels of oxidized DJ-1 in erythrocytes of unmedicated PD patients are markedly higher than those in medicated PD patients and healthy subjects. In the present study, we examined the changes in oxidized DJ-1 levels in the brain and erythrocytes of PD animal models using specific antibodies against Cys-106-oxidized DJ-1. Treatment with PD model compounds such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine significantly elevated the levels of oxidized DJ-1 in erythrocytes. Immunohistochemical analysis also revealed that the number of oxidized DJ-1 antibody-positive cells in the substantia nigra of MPTP-treated mouse increased in a dose-dependent manner. These results suggest that the oxidative modification of DJ-1 in the brain and erythrocytes is involved in the pathogenesis of PD in animal models.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Akazawa YO,Saito Y,Hamakubo T,Masuo Y,Yoshida Y,Nishio K,Shichiri M,Miyasaka T,Iwanari H,Mochizuki Y,Kodama T,Noguchi N,Niki E

doi

10.1016/j.neulet.2010.08.007

subject

Has Abstract

pub_date

2010-10-15 00:00:00

pages

201-5

issue

3

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(10)01041-4

journal_volume

483

pub_type

杂志文章
  • Changes in dopamine release in caudate nuclei and substantia nigrae after electrical stimulation of the posterior interposate nucleus of cat cerebellum.

    abstract::The effect of unilateral electrical stimulation of the posterior interposate nucleus of the cerebellum was examined on the activity of the nigro-striatal dopaminergic pathways on both sides of the brain in alpha-chloralose anaesthetized cats. Push-pull cannulae were inserted into both caudate nuclei and both substanti...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(80)90079-8

    authors: Nieoullon A,Dusticier N

    更新日期:1980-04-01 00:00:00

  • Acute excitotoxicity in chick retina caused by the unusual amino acids BOAA and BMAA: effects of MK-801 and kynurenate.

    abstract::beta-N-Oxalylamino-L-alanine (BOAA) and beta-N-methylamino-L-alanine (BMAA) were tested for their ability to produce acute excitotoxicity in in embryonic chick retina. gamma-Aminobutyric acid (GABA) release and histology were monitored in retina treated with various concentrations of BOAA, BMAA, kainate (KA), N-methyl...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(89)90093-1

    authors: Zeevalk GD,Nicklas WJ

    更新日期:1989-07-31 00:00:00

  • MicroRNA profiling and the role of microRNA-132 in neurodegeneration using a rat model.

    abstract::MicroRNAs (miRs) are endogenous small RNAs that regulate gene expression at the post-transcriptional level by mediating mRNA degradation or transcriptional inhibition. MiRs were implicated in the pathogenesis of numerous neurodegenerative diseases, including Parkinson's disease (PD). In this study we analyzed the poss...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2013.08.001

    authors: Lungu G,Stoica G,Ambrus A

    更新日期:2013-10-11 00:00:00

  • Global and regional gray matter reductions in ADHD: a voxel-based morphometric study.

    abstract::Attention deficit hyperactivity disorder (ADHD) is a developmental disorder characterized by inattentiveness, motor hyperactivity and impulsivity. According to neuroimaging data, the neural substrate underlying ADHD seems to involve fronto-striatal circuits and the cerebellum. However, there are important discrepancie...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2005.07.020

    authors: Carmona S,Vilarroya O,Bielsa A,Trèmols V,Soliva JC,Rovira M,Tomàs J,Raheb C,Gispert JD,Batlle S,Bulbena A

    更新日期:2005-12-02 00:00:00

  • Non-coding RNA regulators of diabetic polyneuropathy.

    abstract::Diabetic polyneuropathy is a common and disturbing complication of diabetes mellitus, presenting patients and caregivers with a substantial disease burden. Emerging mechanisms which are underlying diabetes may provide novel pathways to understand diabetic polyneuropathy (DPN). Specifically, non-coding RNA molecules co...

    journal_title:Neuroscience letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.neulet.2020.135058

    authors: Meydan C,Üçeyler N,Soreq H

    更新日期:2020-07-13 00:00:00

  • A fractal analysis of pyramidal neurons in mammalian motor cortex.

    abstract::Pyramidal neurons in the mammalian cerebral cortex can be described by a fractal dimension (Mandelbrot, 1982), which is an objective, quantitative measure of the complexity of their soma/dendritic borders. In the cat, the fractal dimensions of lamina V cells, which include pyramidal tract neurons (PTN), indicate that ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90240-t

    authors: Porter R,Ghosh S,Lange GD,Smith TG Jr

    更新日期:1991-09-02 00:00:00

  • The increase in morphine antinociceptive potency produced by carrageenan-induced hindpaw inflammation is blocked by naltrindole, a selective delta-opioid antagonist.

    abstract::Carrageenan-induced inflammation of the rat hindpaw has been used as a model for persistent pain of inflammatory origin. The induction of inflammation resulting from carrageenan injection in the rat hindpaw has been shown to elicit an increase in the antinociceptive potency of morphine, an effect postulated to be rela...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(94)11199-s

    authors: Ossipov MH,Kovelowski CJ,Porreca F

    更新日期:1995-01-30 00:00:00

  • The discharge of subthalamic neurons is modulated by inhibiting the nitric oxide synthase in the rat.

    abstract::The effects induced on the discharge of subthalamic spontaneously active neurons by inhibiting the enzyme nitric oxide synthase was studied in two groups of urethane-anesthetized rats. In the first group of animals (n = 10), the activity of subthalamic single units was recorded before and after the systemic administra...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2005.11.054

    authors: Sardo P,Ferraro G,Carletti F,D'Agostino S,La Grutta V

    更新日期:2006-04-03 00:00:00

  • Pentylenetetrazol-induced seizures increase [3H]L-2-amino-4-phosphonobutyrate binding in discrete regions of the rat brain.

    abstract::Convulsions were induced in rats by a single injection of pentylenetetrazol (PTZ) and [3H]L-2-amino-4-phosphonobutyrate ([3H]L-AP4) in vitro receptor autoradiography was used to evaluate the effects on the expression of group III metabotropic glutamate receptors. Significant increases by 60-80% in [3H]L-AP4 binding wa...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(99)00235-9

    authors: Thomsen C

    更新日期:1999-04-30 00:00:00

  • Ontogenetic changes in neuropeptide Y-like-immunoreactivity in the terminal nerve of the chum salmon and the cloudy dogfish, with special reference to colocalization with gonadotropin-releasing hormone-immunoreactivity.

    abstract::We observed ontogenetic changes of neuropeptide Y (NPY)-like-immunoreactivity in the terminal nerve (TN) of the chum salmon, a teleost, and the cloudy dogfish, an elasmobranch. In the chum salmon, NPY-like-immunoreactive (NPY-IR) cells first appeared in the olfactory placode of embryos at 16 days after fertilization, ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(96)12828-7

    authors: Chiba A,Oka S,Honma Y

    更新日期:1996-07-26 00:00:00

  • The formation of reactive oxygen species in a fraction of rat brain by metabolism of nitric oxide.

    abstract::The potential of nitric oxide for the induction of reactive oxygen species (ROS) has been evaluated in a cerebral synaptosomal fraction. Nitric oxide (NO) was generated using S-nitroso-N-acetylpenicillamine (SNAP). NO stimulated ROS production, assayed using a fluorescent probe. This stimulation was largely inhibited ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(94)90409-x

    authors: Bondy SC,Naderi S

    更新日期:1994-02-28 00:00:00

  • Absence of dystrophin in two patients with Becker type Xp21 muscular dystrophy.

    abstract::Two patients with Xp21 muscular dystrophy Becker type showed absence of dystrophin in muscle biopsy tested with 4 antibodies (polyclonal anti-60 kDa, monoclonal against the rod domain, the C-terminus and the N-terminus). DNA analysis did not detect any deletion in one patient and demonstrated deletion of exons 3-7 in ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(92)90769-4

    authors: Mongini T,Palmucci L,Doriguzzi C,Chiadoò-Piat L,Restagno G

    更新日期:1992-11-23 00:00:00

  • Localization of kappa-opioid binding sites in the guinea pig cerebellum.

    abstract::The cellular location of kappa-opioid binding sites in the guinea pig cerebellum has been investigated. kappa-Opioid sites were labelled using [3H]ethylketocyclazocine in the presence of mu- and delta-blocking ligands. In vitro autoradiography demonstrated that this kappa-opioid binding was localized predominantly in ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(88)90330-8

    authors: Bunn SJ,Wilkin GP

    更新日期:1988-01-11 00:00:00

  • Calcitonin gene-related peptide-mediated increase in K(+)-induced [(3)H]-dopamine release from rat caudal striatal slices.

    abstract::The calcitonin-gene receptor peptide (alphaCGRP) receptor is present in high levels in the caudal striatum of the rat. Previous behavioural experiments have highlighted a possible correlation between alphaCGRP-mediated effects and the dopaminergic system. In this study, we examined the effect of alphaCGRP on K(+)-evok...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(01)02056-0

    authors: Maneuf YP,McKnight AT

    更新日期:2001-09-14 00:00:00

  • The time course of GABA action on the crayfish stretch receptor: evidence for a saturable GABA uptake.

    abstract::The conductance increase induced by bath application of GABA has been measured in voltage-clamped stretch-receptor neurones of crayfish. A rapid conductance increase was obtained only at GABA concentrations above 3.3 X 10(-4) M. The response to lower GABA concentrations (between 10(-4) and 10(-6) M) developed slowly o...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(84)90521-4

    authors: Deisz RA,Dose M,Lux HD

    更新日期:1984-06-29 00:00:00

  • Pressor, dipsogenic, natriuretic and kaliuretic response to central carbachol in rats with lesion of the medial septal area.

    abstract::In the present study we investigated the effect of electrolytic lesion of the medial septal area (MSA) on the dipsogenic, natriuretic, kaliuretic and pressor responses elicited by intracerebroventricular (i.c.v.) injection of the cholinergic agonist carbachol. Freely moving rats with sham or MSA lesion (1-7 days and 1...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90300-i

    authors: Luiz AC,Saad WA,Camargo LA,Renzi A,De Luca Junior LA,Menani JV

    更新日期:1991-11-11 00:00:00

  • Shared motor innervation between dynamic and static intrafusal muscle fibers in the monkey.

    abstract::Distributions of 25 motor axons to 60 intrafusal muscle fibers of 10 poles of monkey spindle were reconstructed from serial 1 micron thick transverse sections of lumbrical muscles. About 44% of motor axons co-innervated two or more types of intrafusal fiber. The (dynamic) bag1 fiber shared motor innervation with the (...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(85)90092-8

    authors: Kucera J

    更新日期:1985-01-07 00:00:00

  • A possible homologue of the suprachiasmatic nucleus in the hypothalamus of lampreys (Lampetra fluviatilis L.).

    abstract::This study in lampreys (Lampetra fluviatilis L.) is concerned with the phylogenetic age of the suprachiasmatic nucleus of the hypothalamus which in mammals receives input from the retinohypothalamic tract and acts as circadian pacemaker. Tracing experiments with the fluorescent dye DiI demonstrated a retinohypothalami...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:

    authors: Weigle C,Wicht H,Korf HW

    更新日期:1996-10-18 00:00:00

  • Acetylcholine activates a nicotinic receptor and an inward current in dorsal motor nucleus of the vagus neurons in vitro.

    abstract::This study examines the effect of acetylcholine (Ach) on parasympathetic vagal neurons in the dorsal motor nucleus of the vagus (DMNX). Patch-clamp techniques were utilized to examine voltage and ligand-gated currents in visualized DMNX neurons in an in vitro slice. Ach (100 microM) activated an inward current, -196.4...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(95)11807-9

    authors: Neff RA,Hansen MK,Mendelowitz D

    更新日期:1995-08-11 00:00:00

  • Gastrin releasing peptide-induced satiety is associated with hypothalamic and brainstem changes in chicks.

    abstract::Gastrin releasing peptide (GRP) is involved in the stimulation of gastric acid release from the stomach. It also mediates effects on feeding behavior. It is associated with anorexigenic effects in both mammalian and avian species, but the mechanism of action is unknown in any species. The aim of the present study was ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2019.134529

    authors: Bohler M,Dougherty C,Tachibana T,Gilbert ER,Cline MA

    更新日期:2019-11-20 00:00:00

  • Exploring vocal recovery after cranial nerve injury in Bengalese finches.

    abstract::Songbirds and humans use auditory feedback to acquire and maintain their vocalizations. The Bengalese finch (Lonchura striata domestica) is a songbird species that rapidly modifies its vocal output to adhere to an internal song memory. In this species, the left side of the bipartite vocal organ is specialized for prod...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2012.12.016

    authors: Urbano CM,Peterson JR,Cooper BG

    更新日期:2013-02-08 00:00:00

  • Hippocampal seizures and striatal regulation: a possible functional pathway.

    abstract::Experimental findings have suggested the possibility of a functional relationship between the basal ganglia and the hippocampus. Previous research has revealed a predominantly inhibitory action of the caudate nucleus (CN) and an excitatory effect of the globus pallidus (GP) on electrically induced hippocampal afterdis...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(86)90526-4

    authors: La Grutta V,Sabatino M,Ferraro G,Liberti G,La Grutta G

    更新日期:1986-12-23 00:00:00

  • In vivo regulation of acetylcholine release via adenosine A1 receptor in rat cerebral cortex.

    abstract::The roles of the endogenous adenosine on acetylcholine release via adenosine A1 receptor were investigated in rat cerebral cortex using brain microdialysis. Oral administration of KF15372 (8-dicyclopropylmethyl-1,3-dipropylxanthine), a novel selective adenosine A1 receptor antagonist, at doses of 1.25, 5, and 20 mg/kg...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(96)12632-x

    authors: Kurokawa M,Shiozaki S,Nonaka H,Kase H,Nakamura J,Kuwana Y

    更新日期:1996-05-17 00:00:00

  • Somatotopical relationships between cortical activity and reflex areas in reflexology: a functional magnetic resonance imaging study.

    abstract::We examined the somatotopical relationship between cortical activity and sensory stimulation of reflex areas in reflexology using functional magnetic resonance imaging. Three reflex areas on the left foot, relating to the eye, shoulder, and small intestine were stimulated during the experiment. A statistical analysis ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2008.10.022

    authors: Nakamaru T,Miura N,Fukushima A,Kawashima R

    更新日期:2008-12-19 00:00:00

  • The glycine site modulates NMDA-mediated changes of intracellular free calcium in cultures of hippocampal neurons.

    abstract::Recent evidence indicates that the N-methyl-D-aspartate (NMDA) receptor-channel complex contains a glycine subunit whose activation may be necessary for channel operation. It has been previously shown that stimulation of the NMDA receptor leads to an increase in intracellular ionic Ca2+ [( Ca2+]i); therefore, we exami...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(90)90071-g

    authors: Oliver MW,Shacklock JA,Kessler M,Lynch G,Baimbridge KG

    更新日期:1990-07-03 00:00:00

  • A possible retinal information route to the circadian pacemaker through pretectal areas in the hagfish, Eptatretus burgeri.

    abstract::By recording the locomotor activity rhythm of hagfish, Eptatretus burgeri, in which surgical lesions of the pretectal areas were made, we searched for the route of light information from the eyes to the circadian pacemaker, which is considered to be located in the preoptic nucleus. The entrainment of circadian activit...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(95)11645-d

    authors: Ooka-Souda S,Kadota T,Kabasawa H,Takeuchi H

    更新日期:1995-06-16 00:00:00

  • Interamygdaloid connections in the rat studied by the horseradish peroxidase method.

    abstract::Neurons of the rat amygdaloid body were labeled with horseradish peroxidase following its injection into contralateral nuclei of the amygdala. The results strongly suggest that there is a contralateral amygdaloid projection from the basal (dorsal and ventral) nuclei of amygdala; it terminates in the medial, central an...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(81)90416-x

    authors: Nitecka L,Amerski L,Narkiewicz O

    更新日期:1981-10-01 00:00:00

  • Synaptic terminals from an identified motoneuron in locust muscle: comparison between first instar larva and adult.

    abstract::Dimensions and innervation of muscle fibers in locust jumping muscle from 1st instar larva and adult are compared. Fibers innervated by only one motoneuron were investigated. During postembryonic development, the size, but not the number, of muscle fibers increases. The number of synaptic contacts per fiber increases ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(81)90436-5

    authors: Walther C

    更新日期:1981-12-23 00:00:00

  • Aglycemia and ischemia depress monosynaptic and polysynaptic reflexes in neonatal rat spinal cord in vitro by involving different types of 5-hydroxytryptamine receptors.

    abstract::Involvement of 5-hydroxytryptaminergic (5-HT) system for aglycemia- and ischemia-induced depression of the spinal reflexes was evaluated. The monosynaptic (MSR) and polysynaptic (PSR) reflex potentials were elicited in the ventral root by stimulating the corresponding dorsal root in an isolated spinal cord from neonat...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2004.09.033

    authors: Deshpande SB,Jha A

    更新日期:2004-11-30 00:00:00

  • Effects of ambient lighting on visual discrimination, forward masking and attentional facilitation.

    abstract::Differences between neural processing underling day and night vision occur at initial transduction steps. However, comparison of a visual task performance in photopic versus scotopic situations has an intrinsic problem: ambient light levels directly affect the contrast between stimuli and background. By using a simple...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2005.09.033

    authors: Kihara AH,Tsurumaki AM,Ribeiro-do-Valle LE

    更新日期:2006-01-23 00:00:00