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Glutamate-induced calcium responses in rat primary cortical cultures are potentiated by co-administration of glutamate transport inhibitors.

Abstract：

:The effects of glutamate uptake inhibitors on the L-glutamate-induced increase in intracellular calcium concentrations were assessed in rat primary cortical cultures. The glutamate (10 microM)-induced rise in intracellular calcium concentrations was strongly and dose dependently increased and prolonged by simultaneous administration of micromolar concentrations of the reference glutamate transport inhibitors, L-trans-pyrrolidine-2,4-dicarboxylate (PDC) and D- or L-threo-beta-hydroxyaspartate. PDC in concentrations up to 10 microM showed no effect on intracellular calcium when administered alone. The anticancer drug tamoxifen, which was found to be effective as a glutamate transport inhibitor, did not increase but prolonged the cellular calcium response to glutamate, indicating that it had a different mechanism of action compared to that of standard glutamate transport inhibitors. The findings suggest that compounds which inhibit the glutamate transporter may potentiate the excitatory glutamatergic signal of cultured neurons when administered together with glutamate.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Freund WD,Grieshop B,Neumann U,Reddig S

doi

10.1016/0304-3940(95)11395-d

subject

Has Abstract

pub_date

1995-03-16 00:00:00

pages

61-4

issue

1

eissn

0304-3940

issn

1872-7972

pii

030439409511395D

journal_volume

188

pub_type

杂志文章

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