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Response of risperidone treatment may be associated with polymorphisms of HTT gene in Chinese schizophrenia patients.

Abstract：

:Serotonin transporter (5-HTT) is a key component of the serotonergic neurotransmitter system. Few studies have focused on polymorphisms of the serotonin transporter and antipsychotic response and, in particular, there have so far been no published studies on the association between the serotonin transporter and response to risperidone. This study examined the relationship between two polymorphisms of the serotonin transporter and the efficacy of risperidone treatment in 129 patients with schizophrenia. Our results revealed that patients with l allele of HTTRLP showed a greater improvement than those without l allele on the overall brief psychiatric rating scale (BPRS) (P=0.025). But no such relationship was found for the HTTVNTR. In haplotype analysis, the frequency of L-12 haplotype showed a significant difference between the responder group and the non-responder group (P=0.005). Our study has, for the first time, produced evidence that the potential for therapy in patients with schizophrenia is related to the HTTRLP polymorphism in the HTT gene and haplotype L-12 may help to predict risperidone treatment efficiency.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Wang L,Yu L,He G,Zhang J,Zhang AP,Du J,Tang RQ,Zhao XZ,Ma J,Xuan JK,Xiao Y,Gu NF,Feng GY,Xu MQ,Xing QH,He L

doi

10.1016/j.neulet.2006.09.014

subject

Has Abstract

pub_date

2007-02-27 00:00:00

pages

1-4

issue

1

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(06)00945-1

journal_volume

414

pub_type

杂志文章

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