Effects of near-ultraviolet light on the nocturnal serotonin N-acetyltransferase activity of rat pineal gland.

Abstract:

:Effects of near-ultraviolet (UV-A; 325-390 nm, peak at 365 nm) light on the activity of the pineal serotonin N-acetyltransferase (NAT; a penultimate and key regulatory enzyme in melatonin biosynthesis) were examined in rats. Acute exposure of dark-adapted animals to UV-A radiation produced a marked suppression of NAT activity of the pineal gland, the effect being dependent on exposure time. The decrease in the night-time NAT activity evoked by a 1-min pulse of UV-A light (as well as by a 15-s pulse of broad-band visible light) gradually deepened during the first 40 min of treatment of animals with constant darkness, then the enzyme activity began to rise reaching control values by 3 h. Treatment of rats with a protein synthesis inhibitor, cycloheximide, attenuated this night-driven reactivation of the pineal NAT activity. The presented results provide evidence that UV-A light is a powerful signal capable of controlling melatonin biosynthesis in rat pineal gland.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Zawilska JB,Rosiak J,Nowak JZ

doi

10.1016/s0304-3940(98)00085-8

subject

Has Abstract

pub_date

1998-02-27 00:00:00

pages

49-52

issue

1-3

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(98)00085-8

journal_volume

243

pub_type

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