Abstract:
:Immunomorphological staining demonstrates that class I major histocompatibility complex (MHC)-coded antigen expression can be selectively induced on otherwise class I-negative rat nerve cells by peripheral axotomy. Induction of class I as well as class II antigen expression was simultaneously seen on non-neural cells in the immediate vicinity of the injured nerve cells. As nerve regeneration after axotomy includes growth of new nerve cell processes and formation of new nerve cell contacts, the present findings raise the question of a role for MHC-coded molecules in cell-cell interactions during nerve cell growth.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Maehlen J,Schröder HD,Klareskog L,Olsson T,Kristensson Kdoi
10.1016/0304-3940(88)90733-1subject
Has Abstractpub_date
1988-09-23 00:00:00pages
8-13issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(88)90733-1journal_volume
92pub_type
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