Abstract:
:The dopamine modulation of microiontophoretic application of antagonists of glutamate metabotropic synaptic transmission was studied in the sensory motor cortex of awake cats during instrumental conditioned reflex. The substances depressed the background and intensity of evoked impulse activity of pyramidal neurons of the sensory-motor cortex and provoked significant increases in the latency of impulse reaction and corresponding conditioned movements of animals. Simultaneous application of the antagonists and dopamine (DA) eliminated their depression of the background and evoked activity of neurons and decreased the latency of the impulse reactions and movements. Similar qualitative effects were observed in experiments with simultaneous application of biccuculine and (RS)-alpha-methyl-4-carboxyphenylglycine. It is supposed that the DA modulation in the brain consists in stabilizing the background and evoked activity of cortical neurons during reduced intensity of metabotropic glutamatergic synaptic transmission. Such modulation can be important when considering some pathological disorders of glutamatergic transmission.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Storozhuk VM,Khorevin VI,Rozumna NM,Villa AE,Tetko IVdoi
10.1016/j.neulet.2003.11.039keywords:
subject
Has Abstractpub_date
2004-02-12 00:00:00pages
127-30issue
2eissn
0304-3940issn
1872-7972pii
S0304394003013673journal_volume
356pub_type
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