Dopamine modulation of glutamate metabotropic receptors in conditioned reaction of sensory motor cortex neurons of the cat.

Abstract:

:The dopamine modulation of microiontophoretic application of antagonists of glutamate metabotropic synaptic transmission was studied in the sensory motor cortex of awake cats during instrumental conditioned reflex. The substances depressed the background and intensity of evoked impulse activity of pyramidal neurons of the sensory-motor cortex and provoked significant increases in the latency of impulse reaction and corresponding conditioned movements of animals. Simultaneous application of the antagonists and dopamine (DA) eliminated their depression of the background and evoked activity of neurons and decreased the latency of the impulse reactions and movements. Similar qualitative effects were observed in experiments with simultaneous application of biccuculine and (RS)-alpha-methyl-4-carboxyphenylglycine. It is supposed that the DA modulation in the brain consists in stabilizing the background and evoked activity of cortical neurons during reduced intensity of metabotropic glutamatergic synaptic transmission. Such modulation can be important when considering some pathological disorders of glutamatergic transmission.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Storozhuk VM,Khorevin VI,Rozumna NM,Villa AE,Tetko IV

doi

10.1016/j.neulet.2003.11.039

keywords:

subject

Has Abstract

pub_date

2004-02-12 00:00:00

pages

127-30

issue

2

eissn

0304-3940

issn

1872-7972

pii

S0304394003013673

journal_volume

356

pub_type

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