The loss of antinociceptive efficacy of spinal morphine in rats with nerve ligation injury is prevented by reducing spinal afferent drive.


:Nerve ligation injury in rats may represent a useful model of some clinical neuropathic pains. Activation of N-methyl-D-aspartate (NMDA) receptors may maintain central sensitivity and contribute to neuropathic pain. Here, nerve injury was produced by unilateral ligation of the L5 and L6 spinal roots of the sciatic nerve of rats. Catheters were inserted for intrathecal ( or local delivery of drugs at the site of nerve ligation. Acute nociception was measured by the 55 degrees C water tail flick test in sham-operated and nerve-injured rats, and allodynia was determined by measuring response to von Frey filaments. In sham-operated rats, morphine (30 micrograms, produced a 60 +/- 14.4% MPE (maximal possible effect). MK-801 pretreatment did not alter tail-flick latency or morphine antinociception in sham-operated rats. In nerve-injured rats, morphine (30 micrograms, produced a significantly lower antinociceptive effect than in controls (34 +/- 6.3% MPE). While MK-801 alone did not alter tail-flick latency in nerve-injured rats, it significantly enhanced the antinociceptive effect of morphine to 84 +/- 16.0% MPE. Bupivacaine (0.2 ml, 0.75% w/v) at the site of injury also significantly increased the efficacy of morphine (100 +/- 0% MPE) without affecting tail flick latency alone. Bupivacaine administered at the site of injury also produced a significant antiallodynic effect of 94 +/- 7.4% MPE. The reduction in antinociceptive efficacy of morphine in nerve injured rats may be due, in part, to an ongoing spontaneous activity initiated by ectopic foci at the site of injury, and possible NMDA receptor-mediated activity of spinal neurons.


Neurosci Lett


Neuroscience letters


Ossipov MH,Lopez Y,Nichols ML,Bian D,Porreca F




Has Abstract


1995-10-20 00:00:00














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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Clément G,Deguine O

    更新日期:2010-01-04 00:00:00

  • Inhibitory action of acetylcholine, baclofen and GTP-gamma-S on calcium channels in adult rat sensory neurons.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Formenti A,Sansone V

    更新日期:1991-10-14 00:00:00

  • Neuroprotective effects of Buyang Huanwu Decoction on neuronal injury in hippocampus after transient forebrain ischemia in rats.

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    pub_type: 杂志文章


    authors: Li XM,Bai XC,Qin LN,Huang H,Xiao ZJ,Gao TM

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Tanaka J,Saito H,Seto K

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Patla AE

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Athreya DN,Van Orden G,Riley MA

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Gemba H,Miki N,Sasaki K

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Gonzálo-Sanz LM,Insausti R

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Kasten MR,Fan Y,Schulz PE

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Raymond V,Hamon A,Grau Y,Lapied B

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    pub_type: 杂志文章


    authors: Chang CK,Tsai CY,Lin LS,Jou SB,Liao SS,Cheng JT

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  • Substances released during tetanic stimulation of rabbit neocortex induce neurite growth in PC-12 cells and long-term potentiation in guinea pig hippocampus.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Sastry BR,Chirwa SS,May PB,Maretić H

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  • Prestin expression in the cochlea of the reeler mouse.

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    pub_type: 杂志文章


    authors: Zheng J,Richter CP,Cheatham MA

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    abstract::Transcranial pulsed current stimulation (tPCS) and transcranial direct current stimulation (tDCS) are two noninvasive neuromodulatory brain stimulation techniques whose effects on human brain and behavior have been studied individually. In the present study we aimed to quantify the effects of tDCS and tPCS, individual...

    journal_title:Neuroscience letters

    pub_type: 杂志文章,随机对照试验


    authors: Thibaut A,Russo C,Morales-Quezada L,Hurtado-Puerto A,Deitos A,Freedman S,Carvalho S,Fregni F

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Errington ML,Dashwood MR

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Huang RC,Lin JY

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Magnusson A,Höglund U,Sjöquist M

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  • Excitatory pathways from Forel's field H to head elevator motoneurones in the cat.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Isa T,Itouji T,Sasaki S

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Mastrodimou N,Thermos K

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Bitting L,Sutin EL,Watson FL,Leard LE,O'Hara BF,Heller HC,Kilduff TS

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Kesh S,Kannan RR,Sivaji K,Balakrishnan A

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Yamauchi S,Kurosu A,Hitosugi M,Nagai T,Oohira A,Tokudome S

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