The loss of antinociceptive efficacy of spinal morphine in rats with nerve ligation injury is prevented by reducing spinal afferent drive.

abstract：:Alzheimer's Disease (AD) is a neurodegenerative disorder with a complex aetiology displayed by multiple pathogenic factors. The APOE varepsilon4 allele represents the only established genetic risk factor for sporadic AD; in addition, previous findings on three single nucleotide polymorphisms (SNPs) located on the APOE...

journal_title：Neuroscience letters

authors： Valenza A,Bizzarro A,Marra C,Lauria A,Guglielmi V,Rossi C,Tiziano FD,Brahe C,Masullo C

更新日期：2010-03-26 00:00:00

abstract：:An ionotropic glutamate receptor of the kainate subtype (GluR6) and a G-protein coupled metabotropic glutamate receptor (mGluR1 alpha) were expressed and studied in two insect cell lines: sf9 cells from Spodoptera frugiperda and MG1 cells from Trichoplusia ni. Application of kainate to GluR6-infected MG1 cells produce...

journal_title：Neuroscience letters

authors： Ross SM,Taverna FA,Pickering DS,Wang LY,MacDonald JF,Pennefather PS,Hampson DR

更新日期：1994-05-23 00:00:00

abstract：:Pain-related evoked potentials (PREP) is an established electrophysiological method to evaluate the signal transmission of electrically stimulated A-delta fibres. Although prerequisite for its clinical use, test-retest-reliability and side-to-side differences of bilateral stimulation in healthy subjects have not been ...

journal_title：Neuroscience letters

authors： Özgül ÖS,Maier C,Enax-Krumova EK,Vollert J,Fischer M,Tegenthoff M,Höffken O

更新日期：2017-04-24 00:00:00

abstract：:Turnover rates, as estimated from the accumulation of the intermediates, 3,4-dihydroxyphenylalanine (DOPA) and 5-hydroxytryptophan (5-HTP) following decarboxylase inhibition, were used to investigate the relationship between central catecholaminergic and serotonergic neurons and the development of hypertension in the ...

journal_title：Neuroscience letters

authors： Shum AY,Chen CS,Hsu SC,Chen CF

更新日期：1987-03-31 00:00:00

abstract：:The effects of glutamate uptake inhibitors on the L-glutamate-induced increase in intracellular calcium concentrations were assessed in rat primary cortical cultures. The glutamate (10 microM)-induced rise in intracellular calcium concentrations was strongly and dose dependently increased and prolonged by simultaneous...

journal_title：Neuroscience letters

authors： Freund WD,Grieshop B,Neumann U,Reddig S

更新日期：1995-03-16 00:00:00

abstract：:The left adrenal gland of the rat was perfused in vitro via the adrenal vein with Krebs-bicarbonate solution to study accumulation of exogenous catecholamines and secretion of endogenous norepinephrine and epinephrine by exposing the gland to various sympathomimetic agents. Perfusions with high concentrations of norep...

journal_title：Neuroscience letters

authors： Wakade AR,Wakade TD

更新日期：1984-09-07 00:00:00

abstract：RATIONALE:Some investigations have shown that the glutamate receptors play a critical role in cognitive processes such as learning and anxiety. OBJECTIVES:The possible involvement of the cholinergic system of the dorsal hippocampus in the anxiolytic-like response induced by MK-801, NMDA receptor antagonist, was invest...

journal_title：Neuroscience letters

authors： Zarrindast MR,Nasehi M,Piri M,Heidari N

更新日期：2011-11-14 00:00:00

abstract：:The effects of Sendai, a paramyxovirus, on the functional activity of 3 cell types, have been studied in vitro to establish whether a virus alone can cause pathophysiological changes. Neuronal cells are depolarized and suffer a loss of excitability which was attributed to an increase in membrane conductance. Spontaneo...

journal_title：Neuroscience letters

authors： Forda SR,Gillies G,Kelly JS,Micklem KJ,Pasternak CA

更新日期：1982-04-26 00:00:00

abstract：BACKGROUND:A single session of aerobic exercise is linked to faster motor responses; however, the effect on rate of short-term learning is less clear. The objective was to evaluate the influence of a single bout of aerobic exercise on the rate of short-term acquisition of a shape-letter association task requiring a mot...

journal_title：Neuroscience letters

authors： Sage MD,Beyer KB,Laylor M,Liang C,Roy EA,McIlroy WE

更新日期：2016-08-26 00:00:00

abstract：:Functionally active N-methyl-D-aspartate (NMDA) receptors on cat medullary respiratory neurones were revealed by local iontophoretic application of DL-2-amino-7-phosphonoheptanoic acid (AP7). Blockade of NMDA receptors by systemic administration of NMDA antagonists (MK-801, phencyclidine, ketamine, AP7) in vagotomized...

journal_title：Neuroscience letters

authors： Foutz AS,Champagnat J,Denavit-Saubié M

更新日期：1988-05-03 00:00:00

abstract：:In rats, immunoreactivity was demonstrated in the brush border of the choroid plexus, in the wall of blood vessels in the brain, and in the brush border of the proximal tubules of the kidney, using the peroxidase-antiperoxidase technique (PAP) and an anti-pulmonary converting-enzyme antibody. These findings correlate ...

journal_title：Neuroscience letters

authors： Rix E,Ganten D,Schüll B,Unger T,Taugner R

更新日期：1981-03-10 00:00:00

abstract：BACKGROUND:Genetic factors may play important roles in the pathogenesis of Parkinson's disease, and more than 40 loci involved in Parkinson's disease have been identified. Due to differing allele frequencies across origins, the associations of these loci and sporadic Parkinson's disease in the Eastern Chinese populatio...

journal_title：Neuroscience letters

authors： Gao T,Zheng R,Ruan Y,Fang Y,Jin C,Cao J,Song Z,Tian J,Pu J,Zhang B

更新日期：2020-09-14 00:00:00

abstract：:Very recent studies in adult gerbils and rats have shown that exposure to sublethal ischemia can confer neuroprotection from subsequent lethal ischemic episodes. To determine if a similar phenomenon can be elicited during the perinatal period, we have developed a preconditioning regimen that involves exposure to normo...

journal_title：Neuroscience letters

authors： Gidday JM,Fitzgibbons JC,Shah AR,Park TS

更新日期：1994-02-28 00:00:00

abstract：:To examine postural stability of the head, slow, undetectable rotations of small amplitude were imposed about a vertical axis while human subjects maintained a stationary body. Six normal subjects were used. The rotations were imposed through an elastic linkage, and lasted 4 s. The amplitude of head rotation was small...

journal_title：Neuroscience letters

authors： Chan R,Rogers DK,McCloskey DI

更新日期：1996-08-23 00:00:00

abstract：:To determine whether a trans-synaptic mechanism triggered the effects of reserpine on adrenomedullary mRNAs encoding the norepinephrine transporter and tyrosine hydroxylase, we administered 10 mg/kg reserpine to rats after unilateral splanchnicotomy, and examined their adrenal medullas using quantitative in situ hybri...

journal_title：Neuroscience letters

authors： Cubells JF,Baker H,Volpe BT,Smith GP,Das SS,Joh TH

更新日期：1995-07-07 00:00:00

abstract：:Immunoreactive beta-endorphin is localized mainly in the synaptosome-enriched subcellular fraction from rat hypothalami. In this report, we demonstrate that release of immunoreactive beta-endorphin from the synaptosome-enriched subcellular fraction is increased by 150% in a medium containing high potassium. This stimu...

journal_title：Neuroscience letters

authors： Fukata J,Nakai Y,Imura H

更新日期：1980-08-01 00:00:00

abstract：:Treatment with dopamine and other dopamine D2 receptor agonists has been shown to induce cell death through activation of caspase-3 pathway. However, initial step that leads to the activation of caspase-3 in D2 receptor-mediated apoptotic pathway remains unclear. Recently, it was shown that a spliced variant of Galpha...

journal_title：Neuroscience letters

authors： López-Aranda MF,Navarro-Lobato I,López-Téllez JF,Blanco E,Masmudi-Martín M,Khan ZU

更新日期：2008-07-04 00:00:00

abstract：:After hypoxic-ischemic insult iron deposited in the brain catalyzes formation of reactive oxygen species. Newborn rats, showing reduced physiological body temperature and their hyperthermic counterparts injected with deferoxamine (DF), a chelator of iron, are protected both against iron-mediated neurotoxicity and agai...

journal_title：Neuroscience letters

authors： Kletkiewicz H,Nowakowska A,Siejka A,Mila-Kierzenkowska C,Woźniak A,Caputa M,Rogalska J

更新日期：2016-08-15 00:00:00

abstract：:Hypoxic-ischemic brain damage (HIBD) leads to acute death and chronic neurological dysfunction in neonates. To date, there is no satisfactory acknowledged strategy to provide neuroprotection completely. Verbascoside (VB) has been proved to possess antioxidative, anti aging and neuroprotective activities. The aim of th...

journal_title：Neuroscience letters

authors： Wei W,Lu M,Lan X,Liu N,Wang H,Du J,Sun T,Li Y,Yu J

更新日期：2019-10-15 00:00:00

abstract：:The chronic administration of phencyclidine-HCl (PCP-HCl), 10 mg/kg, for 6-7 days resulted in a significant increase in the striatal methionine-enkephalin level, although acute administration induced no change of methionine-enkephalin level in this area. The methionine-enkephalin levels in other areas investigated, i....

journal_title：Neuroscience letters

authors： Nabeshima T,Hiramatsu M,Amano M,Furukawa H,Kameyama T

更新日期：1983-05-27 00:00:00

abstract：:A comparison has been made of the effects of carbon monoxide (CO) or nitrogen (N2) exposure on synaptic transmission in the hippocampal slice. CA1 field potentials, evoked by Schaffer collateral stimulation, were unaffected by superfusion of slices with artificial cerebral spinal fluid (ACSF) equilibrated with either ...

journal_title：Neuroscience letters

authors： Doolette DJ,Kerr DI

更新日期：1992-04-13 00:00:00

abstract：:Push-pull cannulae were acutely positioned through previously implanted guides in the globus pallidus of unanesthetized freely moving cats and rats. During slow-flow perfusions, enkephalin release was detected in resting conditions and increased more than 3-fold when both 50 mM K+ and 1.8 mM Ca2+ were present in the p...

journal_title：Neuroscience letters

authors： Bayon A,Shoemaker WJ,Lugo L,Azad R,Ling N,Drucker-Colin RR,Bloom FE

更新日期：1981-06-12 00:00:00

abstract：:The extracellular signal-regulated kinase (ERK) is enriched in the central nervous system, including the dopamine responsive regions such as the striatum and medial prefrontal cortex (mPFC). The kinase is sensitive to changing cellular and synaptic input and is implicated in the regulation of synaptic transmission and...

journal_title：Neuroscience letters

authors： Mao LM,Wang JQ

更新日期：2019-04-23 00:00:00

abstract：:Caffeine is a widely consumed substance that elicits psychomotor stimulant effects and also displays addictive properties. In order to assess the effect of caffeine on striatal neuropeptide mRNA expression, male rats were injected (i.p.) with caffeine at 20, 40 or 80 mg/kg of body weight twice daily for 9 consecutive ...

journal_title：Neuroscience letters

authors： Datta U,Noailles PA,Kraft M,Zhang Y,Angulo JA

更新日期：1997-08-01 00:00:00

abstract：:To isolate the footedness contribution from the hemispheric visual asymmetry contribution to the upright postural control, seven right and six left-footed healthy women were asked to balance on each unipodal stance on an unstable platform for each visual hemispaces. We compared lateral deviations of the centre of pres...

journal_title：Neuroscience letters

authors： Golomer E,Mbongo F

更新日期：2004-09-02 00:00:00

abstract：:We investigated a possible involvement of the prion protein in ventilatory control in four groups of mice, those deficient for the prion protein (PrP(c)), those overexpressing the prion protein, and two groups of genetically and age-matched controls. Ventilatory patterns of unrestrained mice were measured in a whole-b...

journal_title：Neuroscience letters

authors： Boudinot E,Tremblay P,Champagnat J,Foutz AS

更新日期：2002-04-26 00:00:00

abstract：:In the last decade, several genes have been linked to Parkinson's disease (PD), including GIGYF2, ATP13A2 and GBA. To explore whether mutations in these genes contribute to development of PD in the Brazilian population, we screened 110 patients with early-onset PD. No clearly pathogenic mutations were identified in AT...

journal_title：Neuroscience letters

authors： Dos Santos AV,Pestana CP,Diniz KR,Campos M,Abdalla-Carvalho CB,de Rosso AL,Pereira JS,Nicaretta DH,de Carvalho WL,Dos Santos JM,Santos-Rebouças CB,Pimentel MM

更新日期：2010-11-19 00:00:00

abstract：:We investigated the consequences of a progressive damage to the muscular system on the organization of anticipatory postural adjustments (APA) in children with Duchenne muscular dystrophy (DMD). We used a bimanual load-lifting task requiring the stabilization of the forearm position despite its voluntary or imposed un...

journal_title：Neuroscience letters

authors： Jover M,Schmitz C,Bosdure E,Chabrol B,Assaiante C

更新日期：2006-08-07 00:00:00

abstract：:A digoxigenin-labeled antisense 42-mer oligonucleotide was used for the localization of the dopamine D2 receptor mRNA in the rat brain. The digoxigenin label was identified with alkaline phosphatase conjugated sheep-anti-digoxigenin. In good analogy with the known terminal fields of the dopaminergic system, various nu...

journal_title：Neuroscience letters

authors： Brouwer N,Van Dijken H,Ruiters MH,Van Willigen JD,Ter Horst GJ

更新日期：1992-08-17 00:00:00

abstract：:Methyl-CpG binding protein 2 (MECP2) is a chromosome-binding protein that regulates the development and maintenance of brain circuits. Altered function of the protein product of MECP2 plays an important role in the etiology of many neurodevelopmental disorders. Mutations involving a loss of function are implicated in ...

journal_title：Neuroscience letters

authors： Tropea D,Mortimer N,Bellini S,Molinos I,Sanfeliu A,Shovlin S,McAllister D,Gill M,Mitchell K,Corvin A

更新日期：2016-05-16 00:00:00