Rate dependency of the human cortical network subserving executive functions during generation of random number series--a functional magnetic resonance imaging study.

Abstract:

:In a random number generation (RNG) task subjects are instructed to generate the numbers 1-10 in a random fashion. RNG performance is assumed to involve executive functions, as it requires controlled response generation and suppression of habitual responses. To investigate cerebral structures involved in RNG associated executive functions we investigated functional magnetic resonance imaging in eight healthy subjects while performing an RNG task at two different response rates (1 and 2 Hz). During the 1 Hz condition an activation was detected bilaterally in the dorsolateral prefrontal cortex (BA 9/46), the lateral premotor cortex (BA 6), the anterior cingulate (BA 32), the inferior and superior parietal cortex (BA 7/40) and the cerebellar hemispheres. In the 2 Hz condition behavioural data showed higher counting tendencies reflecting poorer executive control. In parallel, a homogenous diminution of the activity in the involved cortical areas was obtained. This finding would support the theory of a cortical network involved in executive functions consisting of distinct brain regions working together rather than a distinct fronto-cortical functional localisation.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Daniels C,Witt K,Wolff S,Jansen O,Deuschl G

doi

10.1016/s0304-3940(03)00496-8

keywords:

subject

Has Abstract

pub_date

2003-07-10 00:00:00

pages

25-8

issue

1

eissn

0304-3940

issn

1872-7972

pii

S0304394003004968

journal_volume

345

pub_type

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