Abstract:
:The chronic administration of phencyclidine-HCl (PCP-HCl), 10 mg/kg, for 6-7 days resulted in a significant increase in the striatal methionine-enkephalin level, although acute administration induced no change of methionine-enkephalin level in this area. The methionine-enkephalin levels in other areas investigated, i.e. the medulla oblongata/pons, the midbrain, the hypothalamus and the cortex, were unchanged after chronic PCP treatment. These results suggest that chronic administration of PCP alters the enkephalinergic neuronal activity in the striatum.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Nabeshima T,Hiramatsu M,Amano M,Furukawa H,Kameyama Tdoi
10.1016/0304-3940(83)90506-2subject
Has Abstractpub_date
1983-05-27 00:00:00pages
69-74issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(83)90506-2journal_volume
37pub_type
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