Abstract:
:The Nef protein of human immunodeficiency virus type 1 (HIV-1) is abundantly expressed in HIV-1-infected astrocytes and shares amino acid sequence homology to alpha-scorpion toxins which bind to potassium channels. Here we report effects of recombinant Nef and alpha-scorpion toxins on membrane potassium transport in human U251 astroglioma cells. 86Rb+ was utilized as a tracer for potassium movements and potassium channel activity was studied by single-channel patch-clamp techniques. Results showed inactivation of a large-conductance potassium channel when Nef was added to the inner leaflet of the cell membrane of inside-out patches of U251 cells. Extracellular addition of Nef or alpha-scorpion toxins to intact glial cells did not alter potassium transport.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Kort JJ,Jalonen TOdoi
10.1016/s0304-3940(98)00495-9subject
Has Abstractpub_date
1998-07-17 00:00:00pages
1-4issue
1eissn
0304-3940issn
1872-7972pii
S0304394098004959journal_volume
251pub_type
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