Abstract：
:Galanin (GAL) is distributed in sympathetic nerves in the cat, and exogenous GAL inhibits cardiac vagal action and lowers blood pressure in this species. This study on anaesthetised cats compares the effects on cardiac vagal action and blood pressure of human, rat and porcine GAL. Human GAL has only recently been sequenced. It is of particular interest as it is not C-terminally amidated, unlike porcine and rat GAL. Many regulatory peptides require a C-terminal amide group for their action. However, human GAL showed similar biological activity to the other (amidated) GALs here. Omission of a single amino acid (Ser6) from rat GAL significantly attenuated both cardiovascular actions studied here.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ulman LG,Evans HF,Iismaa TP,Potter EK,McCloskey DI,Shine Jdoi
10.1016/0304-3940(92)90659-ukeywords:
subject
Has Abstractpub_date
1992-02-17 00:00:00pages
105-8issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(92)90659-Ujournal_volume
136pub_type
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2009-09-18 00:00:00
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更新日期：2019-07-27 00:00:00
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pub_type： 杂志文章
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更新日期：2009-04-10 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2017-03-16 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2005-03-11 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1979-06-01 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1987-02-24 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章,评审
doi：10.1016/j.neulet.2018.10.015
更新日期：2020-05-01 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1998-01-02 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2014.09.042
更新日期：2014-11-07 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1981-09-25 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2012.04.065
更新日期：2012-06-19 00:00:00
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journal_title：Neuroscience letters
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pub_type： 杂志文章,评审
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更新日期：2007-08-31 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.05.029
更新日期：2008-07-25 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(92)90600-c
更新日期：1992-12-07 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.06.061
更新日期：2004-09-16 00:00:00
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journal_title：Neuroscience letters
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更新日期：2001-11-09 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2013.12.060
更新日期：2014-02-21 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2006.09.071
更新日期：2006-12-20 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(93)90836-a
更新日期：1993-09-03 00:00:00
