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Does adenosine participate in the mechanism of spreading depression?

Abstract：

:It is known that depolarization of cortical cells in vivo during cortical spreading depression (CSD) is accompanied by accumulation of cyclic AMP (cAMP). Under similar conditions in vitro adenosine release has been demonstrated. The present study investigates the possible role of adenosine in the mechanism of CSD. Topically applied adenosine penetrated the cortical tissue and induced enhancement of cAMP levels up to 70% above control, but failed to elicit CSD. Threshold of K(+) to evoke CSD was not affected by adenosine. No EEG or slow potential changes were produced by adenosine. Thus adenosine does not seem to play an active role in the mechanism of CSD.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Ueda M,Krivánek J

doi

10.1016/0304-3940(77)90134-3

subject

Has Abstract

pub_date

1977-03-01 00:00:00

pages

177-80

issue

3-4

eissn

0304-3940

issn

1872-7972

pii

0304-3940(77)90134-3

journal_volume

4

pub_type

杂志文章

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