Axotomy affects calcium-sensitive potassium conductance in sympathetic neurones.

Abstract:

:Following peripheral nerve section, the cell body and proximal axon undergo various physiological and morphological changes which may be associated with regrowth. We found that axotomy reduced the amplitude and duration of the afterhyperpolarization (AHP) of the action potential (AP) of bullfrog sympathetic neurones. In addition, the repolarization of the AP was slowed. The Ca2+-channel blocker, Cd2+ (200 microM) produced similar effects in normal cells by blocking the Ca2+-sensitive K+ conductances (gK, Ca) which contribute to the AHP and to AP repolarization. Although Ca2+-channel function was preserved after axotomy, Cd2+ did not affect axotomized neurones. This suggests that axotomy promotes a functional loss of gK, Ca which could reflect a regenerative response of the cell to injury.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Kelly ME,Gordon T,Shapiro J,Smith PA

doi

10.1016/0304-3940(86)90391-5

subject

Has Abstract

pub_date

1986-06-18 00:00:00

pages

163-8

issue

2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(86)90391-5

journal_volume

67

pub_type

杂志文章
  • Hyperpolarizing shift of the M-current activation curve after washout of muscarine in bullfrog sympathetic neurons.

    abstract::The mechanism underlying the over-recovery of an M-type potassium current following the washout of muscarine (20 microM) has been examined. Whole-cell recordings were made from single neurons dissociated from bullfrog sympathetic ganglia. During over-recovery, the maximum M-conductance decreased by about 2.8 nS while ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(96)12495-2

    authors: Tokimasa T,Simmons MA,Schneider CR,Akasu T

    更新日期:1996-03-29 00:00:00

  • Two types of A-current differing in voltage-dependence are expressed by neurons of the rat neostriatum.

    abstract::Transient potassium currents of the A type are thought to be important in a number of physiological processes of excitable cells, including spike repolarization and synaptic integration. This functional diversity may reflect the contribution of distinct subtypes of A channel to cellular behavior. Using the whole-cell ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(89)90122-5

    authors: Surmeier DJ,Bargas J,Kitai ST

    更新日期:1989-09-11 00:00:00

  • Does the neuropathology of human patients with variant Creutzfeldt-Jakob disease reflect haematogenous spread of the disease?

    abstract::To test the hypothesis that the distribution of the pathology in variant Creutzfeldt-Jakob disease (vCJD) represents haematogenous spread of the disease, we studied the spatial correlation between the vacuolation, prion protein (PrP) deposits, and the blood vessel profiles in the cerebral cortex, hippocampus, dentate ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(03)00696-7

    authors: Armstrong RA,Cairns NJ,Ironside JW,Lantos PL

    更新日期:2003-09-04 00:00:00

  • Asymmetries of prefrontal cortex in human episodic memory: effects of transcranial magnetic stimulation on learning abstract patterns.

    abstract::Functional neuroimaging suggests asymmetries of memory encoding and retrieval in the prefrontal lobes, but different hypotheses have been presented concerning the nature of prefrontal hemispheric specialization. We studied an associative memory task involving pairs of Kanji (Chinese) pictographs and unfamiliar abstrac...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(01)02573-3

    authors: Epstein CM,Sekino M,Yamaguchi K,Kamiya S,Ueno S

    更新日期:2002-03-01 00:00:00

  • Long-duration, frequency-dependent motor responses evoked by ventrolateral funiculus stimulation in the neonatal rat spinal cord.

    abstract::Three variations of the in vitro neonatal rat spinal cord preparation were used to investigate motor responses to stimulation of the ventrolateral funiculus (VLF). In a partially hemisected spinal cord preparation, stimuli elicited frequency-dependent activity in lumbar ventral roots that outlasted the stimulus train ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(95)99208-m

    authors: Magnuson DS,Schramm MJ,MacLean JN

    更新日期:1995-06-09 00:00:00

  • Involvement of neurotrophin-3 (NT-3) in the functional elimination of synaptic contacts during neuromuscular development.

    abstract::Confocal immunohistochemistry shows that neurotrophin-3 (NT-3) and its receptor tropomyosin-related tyrosin kinase C (trkC) are present in both neonatal (P6) and adult (P45) mouse motor nerve terminals in neuromuscular junctions (NMJ) colocalized with several synaptic proteins. NT-3 incubation (1-3h, in the range 10-2...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2010.02.040

    authors: Garcia N,Santafé MM,Tomàs M,Lanuza MA,Besalduch N,Tomàs J

    更新日期:2010-04-05 00:00:00

  • Mast cells in nerve end neuromas of mice.

    abstract::The volume density of mast cells was estimated in nerve end neuromas at various time-points after transection of the left sciatic nerve of 6-week-old mice. After an initial reduction in the amount of mast cells there was a steady increase with numerous cells in 6-month-old neuromas. The variation in amount of mast cel...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(86)90497-0

    authors: Nennesmo I,Reinholt F

    更新日期:1986-09-12 00:00:00

  • Six-month cultured cerebral organoids from human ES cells contain matured neural cells.

    abstract::Recently, researchers have developed protocols for human cerebral organoids using human pluripotent stem cells, which mimic the structure of the developing human brain. Existing research demonstrated that human cerebral organoids which undergo short cultivation periods, contain astrocytes, neurons, and neural stem cel...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2018.01.040

    authors: Matsui TK,Matsubayashi M,Sakaguchi YM,Hayashi RK,Zheng C,Sugie K,Hasegawa M,Nakagawa T,Mori E

    更新日期:2018-03-23 00:00:00

  • Stria terminalis conveys a facilitatory estrogen effect on female rat lordosis reflex.

    abstract::The effects of bilateral cut of the stria terminalis (ST) on the dosage of estradiol benzoate (EB) needed to induce the lordosis reflex in the ovariectomized female rat were examined. Seven different doses ranging 0.5-20 micrograms were given s.c. in oil, daily for 2 days in a counterbalanced order, at 3-week interval...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(94)11173-g

    authors: Takeo T,Kudo M,Sakuma Y

    更新日期:1995-01-23 00:00:00

  • GABA receptors distribution in rat substantia nigra.

    abstract::The perikarya of the dopaminergic and non-dopaminergic neurons contained in the substantia nigra were selectively destroyed by a proper, local injection of 6-hydroxydopamine or kainic acid, respectively. Both lesions resulted in a marked decrease of the nigral GABA-binding sites. The effect of 6-hydroxydopamine was re...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(81)90007-0

    authors: De Montis GM,Olianas MC,Mulas G,Lloyd KG,Tagliamonte A

    更新日期:1981-05-29 00:00:00

  • An anatomical study of the origin of sympathetic and sensory innervation of the elbow and knee joint in the monkey.

    abstract::The origin of sympathetic and sensory innervation of the elbow and knee joint was studied by the intra-axonal transport method. After injection of WGA-HRP into the elbow and knee joint unilaterally in adult monkeys (macaca fascicularis), labelled cells were observed ipsilaterally in both the sympathetic and dorsal roo...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90790-z

    authors: Wiberg M,Widenfalk B

    更新日期:1991-06-24 00:00:00

  • Prevention by maternal pancreatic islet transplantation of hypothalamic malformation in offspring of diabetic mother rats is already detectable at weaning.

    abstract::Exposure to gestational diabetes (GD) in rats leads to dysplasia of the ventromedial hypothalamic nucleus (VMN), decisively involved into the regulation of body weight and metabolism. Recently, we have shown here that VMN malformation is absent in adult offspring of GD mothers treated by pancreatic islet transplantati...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2003.08.066

    authors: Harder T,Franke K,Fahrenkrog S,Aerts L,Van Bree R,Van Assche FA,Plagemann A

    更新日期:2003-12-11 00:00:00

  • Cortico-muscular coherence parallels coherence of postural tremor and MEG during static muscle contraction.

    abstract::Corticokinematic coherence (CKC), i.e., coherence calculated between MEG and an accelerometer signal, recording movement kinematics, can be used for functional mapping of the sensorimotor cortex. Cortical sources of CKC, induced by both voluntary and passive movements, localize at the proximity of sensorimotor cortex....

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2015.06.034

    authors: Airaksinen K,Lehti T,Nurminen J,Luoma J,Helle L,Taulu S,Pekkonen E,Mäkelä JP

    更新日期:2015-08-18 00:00:00

  • Leucine-enkephalin-like immunoreactive afferent fibers to pudendal motoneurons in the cat.

    abstract::Leucine-enkephalin-like immunoreactive (ENK-LI) afferent fibers to the feline homologue of the Onuf's nucleus (pudendal motoneurons) originate mainly from lamina X of the sacral cord. They make synaptic contacts chiefly upon dendrites of pudendal motoneurons; the synaptic terminals most often contain pleomorphic synap...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(85)90409-4

    authors: Konishi A,Itoh K,Sugimoto T,Yasui Y,Kaneko T,Takada M,Mizuno N

    更新日期:1985-10-24 00:00:00

  • Gene expression of the nicotinic acetylcholine receptor alpha 4 subunit in the frontal cortex in Parkinson's disease patients.

    abstract::Cognitive impairment in Parkinson's disease is accompanied by a marked decrease of cerebrocortical nicotinic receptors. To study the putative site of impaired receptor synthesis, frontal cortices of Parkinson patients with cognitive dysfunction have been screened for the expression of the nicotinic receptor alpha 4 su...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(95)11367-6

    authors: Schröder H,de Vos RA,Jansen EN,Birtsch C,Wevers A,Lobron C,Nowacki S,Schröder R,Maelicke A

    更新日期:1995-03-10 00:00:00

  • Distribution of the pro-opiomelanocortin-immunoreactive axons in relation to the serotoninergic neurons in the dorsal raphe nucleus of the rat.

    abstract::The anatomical relationships between pro-opiomelanocortin-containing axons and serotonin neurons in the nucleus raphe dorsalis (NRD) of the rat were examined at the light microscope level with antibodies against CLIP (corticotropin-like intermediate lobe peptide), alpha-MSH (alpha-melanocyte-stimulating hormone) and s...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90217-h

    authors: Zheng Z,Léger L,Cespuglio R,Jouvet M

    更新日期:1991-09-02 00:00:00

  • Gene expression and association analysis of the epithelial membrane protein 1 gene in major depressive disorder in the Japanese population.

    abstract::The epithelial membrane protein 1 (EMP1) plays a role in neuronal differentiation and neurite outgrowth, which are involved in the pathogenesis of major depressive disorder (MDD). We sought to determine whether the EMP1 gene is implicated in MDD. We determined the mRNA expression levels of the EMP1 gene in peripheral-...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2010.12.001

    authors: Nakataki M,Iga J,Numata S,Yoshimoto E,Kodera K,Watanabe SY,Song H,Ueno S,Ohmori T

    更新日期:2011-02-04 00:00:00

  • Using virtual reality to analyze links between handball thrower kinematics and goalkeeper's reactions.

    abstract::This work investigates the design of a new method to evaluate the importance of visual elements taken into account by a handball goalkeeper facing a thrower. Virtual reality was used to design and reproduce standardised situations in a controlled environment. Under such conditions, it was possible to isolate for inves...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2004.09.023

    authors: Bideau B,Multon F,Kulpa R,Fradet L,Arnaldi B,Delamarche P

    更新日期:2004-11-30 00:00:00

  • Stress and corticosterone enhance cognitive recovery from hippocampal stroke in rats.

    abstract::When locally infused, the potent vasoconstrictor, endothelin-1 (ET-1) produces partial ischemic damage in many regions of the brain, including the hippocampus. The hippocampus is known for a high density of glucocorticoid receptors and for the potent actions of stress and corticosterone to modulate function. The curre...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2009.06.096

    authors: Faraji J,Lehmann H,Metz GA,Sutherland RJ

    更新日期:2009-10-25 00:00:00

  • Xenon fails to inhibit capsaicin-evoked CGRP release by nociceptors in culture.

    abstract::To investigate whether the xenon-induced inhibition of the transient receptor potential vanilloid type 1 (TRPV1) ion channel in rat dorsal root ganglion (DRG) neurons reduces nociceptive processing, we examined the effect of xenon in reducing the release of calcitonin gene-related peptide (CGRP) from those neurons. We...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2011.05.051

    authors: Calcott G,White JP,Nagy I

    更新日期:2011-07-20 00:00:00

  • Time of day differences in IL1beta and TNFalpha mRNA levels in specific regions of the rat brain.

    abstract::Interleukin-1beta (IL1beta) and tumor necrosis factor-alpha (TNFalpha) are involved in several physiological functions regulated by brain. The current studies were performed to determine whether a diurnal rhythm of IL1beta and TNFalpha mRNAs, determined by real time RT-PCR, existed in specific brain regions linked to ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2003.07.019

    authors: Cearley C,Churchill L,Krueger JM

    更新日期:2003-11-27 00:00:00

  • Nitric oxide plasma concentration associated with cognitive impairment in patients with recurrent depressive disorder.

    abstract:BACKGROUND/AIM:Depressive disorders are multifactorial diseases, in which cognitive impairment is one of the characteristic feature. One of the molecules that regulate of various cognitive, emotional and behavioural processes is nitric oxide (NO), synthesized from l-arginine by a family of isoformic enzymes known as ni...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2012.01.018

    authors: Talarowska M,Gałecki P,Maes M,Orzechowska A,Chamielec M,Bartosz G,Kowalczyk E

    更新日期:2012-02-29 00:00:00

  • Neuronal intranuclear inclusions in spinocerebellar ataxia type 2: triple-labeling immunofluorescent study.

    abstract::Spinocerebellar ataxia type 2 (SCA2) is associated with an expansion of CAG/polyglutamine-repeat of a gene of unknown function. We performed an immunohistochemical study to identify the immunolocalization of the disease protein ataxin-2 in normal and SCA2 patients. Although normal and expanded ataxin-2 were ubiquitous...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(99)00656-4

    authors: Koyano S,Uchihara T,Fujigasaki H,Nakamura A,Yagishita S,Iwabuchi K

    更新日期:1999-10-01 00:00:00

  • Greater electroencephalographic coherence between left and right temporal lobe structures during increased geomagnetic activity.

    abstract::Interhemispheric coherence for 19 channel EEG activity collected over a three year period from 184 men and women who relaxed in a quiet, darkened chamber showed significant increased coherence between caudal temporal regions for the 11 Hz frequency band during increased (>∼8 nT) global geomagnetic activity at the time...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2013.11.024

    authors: Saroka KS,Caswell JM,Lapointe A,Persinger MA

    更新日期:2014-02-07 00:00:00

  • Global motion perception is associated with motor function in 2-year-old children.

    abstract::The dorsal visual processing stream that includes V1, motion sensitive area V5 and the posterior parietal lobe, supports visually guided motor function. Two recent studies have reported associations between global motion perception, a behavioural measure of processing in V5, and motor function in pre-school and school...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2017.08.062

    authors: Thompson B,McKinlay CJD,Chakraborty A,Anstice NS,Jacobs RJ,Paudel N,Yu TY,Ansell JM,Wouldes TA,Harding JE,CHYLD Study Team.

    更新日期:2017-09-29 00:00:00

  • PIN1-842G/C and -667T/C polymorphisms are not associated with the susceptibility of Alzheimer's disease: pooled analysis of epidemiologic studies.

    abstract::Associations between PIN1 gene polymorphisms and Alzheimer's disease (AD) risk remain controversial, possibly because single studies often lack sufficient statistical power. In this study, we performed a meta-analysis to evaluate the association of two commonly studied PIN1 polymorphisms, -842G/C and -667T/C, with the...

    journal_title:Neuroscience letters

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.neulet.2012.12.026

    authors: Cao L,Wang F,Ge H,Wu PC,Qu P,Chen GH,Gao ZL

    更新日期:2013-02-22 00:00:00

  • Nitrous oxide and xenon increase noradrenaline release in the cerebral cortex in vivo and in vitro.

    abstract::Noradrenaline in the central nervous system plays an important role in regulating physiological functions, and is a key mechanistic component of general anesthesia. The purpose of this present study was to determine if nitrous oxide and xenon modulate noradrenaline release in the cerebral cortex. We performed a series...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2009.11.074

    authors: Yoshida H,Kushikata T,Tose R,Kudo M,Kudo T,Hirota K

    更新日期:2010-01-22 00:00:00

  • Nicergoline facilitates vestibular compensation in aged male rats with unilateral labyrinthectomy.

    abstract::The ergoline derivatives, nicergoline (NIC) or dihydroergocristine (DHE) were administered at various doses (0.1, 0.5 and 1 mg/kg) to aged male rats subjected to labyrinth unilateral lesion (LBX). The nystagmus rate appeared to be lower in animals treated with DHE or NIC 1mg/kg than in saline-injected rats, when obser...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(99)00328-6

    authors: Rampello L,Drago F

    更新日期:1999-05-28 00:00:00

  • Serotonergic and non-serotonergic projections from the interpeduncular nucleus to the ventral hippocampus in the rat.

    abstract::The localization of serotonin and non-serotonin-containing cell bodies in the interpeduncular nucleus of the rat that project to the hippocampal formation was studied using the technique of retrograde tracing of Granular Blue and immunohistochemistry on the same sections. The results indicate that the caudal magnocell...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(84)90256-8

    authors: Groenewegen HJ,Steinbusch HW

    更新日期:1984-09-28 00:00:00

  • The glutamate receptor of the Qp-type activates protein kinase C and is regulated by protein kinase C.

    abstract::In striatal neurons in primary culture quisqualate potently stimulated the formation of inositol phosphates via a metabotropic receptor we recently termed Qp in order to distinguish it from the classical ionotropic quisqualate receptor termed Qi. Here we show that 10 microM of quisqualate activated in a rapid and tran...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(90)90553-l

    authors: Manzoni OJ,Finiels-Marlier F,Sassetti I,Blockaert J,le Peuch C,Sladeczek FA

    更新日期:1990-02-05 00:00:00