Abstract:
:Following peripheral nerve section, the cell body and proximal axon undergo various physiological and morphological changes which may be associated with regrowth. We found that axotomy reduced the amplitude and duration of the afterhyperpolarization (AHP) of the action potential (AP) of bullfrog sympathetic neurones. In addition, the repolarization of the AP was slowed. The Ca2+-channel blocker, Cd2+ (200 microM) produced similar effects in normal cells by blocking the Ca2+-sensitive K+ conductances (gK, Ca) which contribute to the AHP and to AP repolarization. Although Ca2+-channel function was preserved after axotomy, Cd2+ did not affect axotomized neurones. This suggests that axotomy promotes a functional loss of gK, Ca which could reflect a regenerative response of the cell to injury.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Kelly ME,Gordon T,Shapiro J,Smith PAdoi
10.1016/0304-3940(86)90391-5subject
Has Abstractpub_date
1986-06-18 00:00:00pages
163-8issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(86)90391-5journal_volume
67pub_type
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