Abstract：
:When locally infused, the potent vasoconstrictor, endothelin-1 (ET-1) produces partial ischemic damage in many regions of the brain, including the hippocampus. The hippocampus is known for a high density of glucocorticoid receptors and for the potent actions of stress and corticosterone to modulate function. The current experiment evaluates the effects of stress and corticosterone on the severity of memory impairment and anatomical pathology produced by hippocampal mini-stroke. Rats with ET-1-induced mini-stroke were exposed to mild restraint stress (1 h/day) or oral corticosterone (0.5 mg/kg) for 16 consecutive days. Spatial memory was then tested in the Morris water task (MWT) and the ziggurat task (ZT). The groups ET-1+stress and ET-1+corticosterone performed significantly better in both tasks than the ET-1-only group. This suggests that increasing corticosteroid levels alleviates the hippocampal stroke-induced memory deficits. Hippocampal volumetric assessment also revealed that both the post-stroke stress and corticosteroid treatment significantly decreased the volume of hippocampal damage. The findings support the view that elevated levels of corticosterone may exert neuroprotective effects in the hippocampus following stroke.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Faraji J,Lehmann H,Metz GA,Sutherland RJdoi
10.1016/j.neulet.2009.06.096subject
Has Abstractpub_date
2009-10-25 00:00:00pages
248-52issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(09)00883-0journal_volume
462pub_type
杂志文章abstract：:Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors which belong to the nuclear receptor family. We examined whether PPARalpha agonists and resveratrol, a polyphenol contained in grapes, protect the brain against ischemia. To investigate whether resveratrol activates PPARs, w...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2003.09.001
更新日期：2003-12-11 00:00:00
abstract：:We immunohistochemically examined the expression of glycogen synthase kinase-3beta (GSK-3beta) in the brains of Parkinson's disease (PD) patients. GSK-3beta was localized in punctate structures in the cytosol of subsets of neurons in the midbrain and upper pons. GSK-3beta was also localized in Lewy bodies (LBs) as was...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.10.104
更新日期：2009-01-09 00:00:00
abstract：:Following virus infection of the central nervous system, microglia become activated and undergo morphological as well as functional transformations, thereby initiating effective antiviral actions. Herein, we have examined the contribution of nuclear factor kappaB (NF-kappaB) and mitogen-activated protein kinase (MAPK)...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2006.12.058
更新日期：2007-03-13 00:00:00
abstract：:The localization of substance P (SP) and calcitonin gene-related peptide (CGRP) was studied in the untreated spinal cord of the frog using single or double immunohistochemical stainings. SP and CGRP appear to coexist in the primary afferent fibers and in the marginal and submarginal dorsal horn zones, as well as in th...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(87)90462-9
更新日期：1987-10-05 00:00:00
abstract：:Emotions organize human and animal behaviour by automatically adjusting their actions at multiple physiological and behavioural scales. Recently, pattern recognition techniques have emerged as an important tool for quantifying the neural, physiological, and phenomenological organization of emotions in humans. Here we ...
journal_title：Neuroscience letters
pub_type： 杂志文章,评审
doi：10.1016/j.neulet.2017.07.012
更新日期：2019-02-06 00:00:00
abstract：:Although first mentions about calcium disturbances in psychiatric diseases appeared more than 30 years ago, the most recent genomic and proteomic findings confirmed a significant role of Ca2+ and Ca2+-regulated pathways in development of neuropathological processes, including bipolar disorder and schizophrenia. Moreov...
journal_title：Neuroscience letters
pub_type： 杂志文章,评审
doi：10.1016/j.neulet.2017.08.005
更新日期：2018-01-10 00:00:00
abstract：:It is known that depolarization of cortical cells in vivo during cortical spreading depression (CSD) is accompanied by accumulation of cyclic AMP (cAMP). Under similar conditions in vitro adenosine release has been demonstrated. The present study investigates the possible role of adenosine in the mechanism of CSD. Top...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(77)90134-3
更新日期：1977-03-01 00:00:00
abstract：:By studying the binding of [3H]glycine and [3H]glutamate to rat synaptic membranes in the presence of 2-amino-5-phosphonovalerate (APV) and kynurenate (KYN) we have demonstrated that KYN is more potent than APV in displacing [3H]glycine, while an opposite order of potency was seen in displacing [3H]glutamate. Moreover...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(89)90402-3
更新日期：1989-01-30 00:00:00
abstract：:We have previously demonstrated that differences in neuropathic pain-like behaviors after sciatic nerve injury genetically maps to the major histocompatibility complex (MHC) in rats carrying RT1(c) or RT1(av1) haplotypes on the Piebald Virol Glaxo (PVG) background. In order to further explore the genetic contribution ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.07.027
更新日期：2008-09-19 00:00:00
abstract：:There is a growing interest for using quantitative EEG and LORETA current source density in clinical and research settings. Importantly, if these indices are to be employed in clinical settings then the reliability of these measures is of great concern. Neuroguide (Applied Neurosciences) is sophisticated software deve...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2012.04.035
更新日期：2012-06-14 00:00:00
abstract：:In lateral line and electrosensory systems of fish, the animal's own movements create unwanted stimulation that could interfere with the detection of biologically important signals. Here we report that an adaptive filter in the medullary nuclei of both senses suppresses self-stimulation. Second-order electrosensory ne...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(94)90007-8
更新日期：1994-06-20 00:00:00
abstract：:Topical application of horseradish peroxidase (HRP) to the ventral surface of the medulla oblongata revealed various cells with axons terminating near this region. Fibers traced from the ventral surface originated in the nucleus of the tractus solitarius and the dorsal nucleus of the vagus, both near the dorsal surfac...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(79)96054-3
更新日期：1979-05-01 00:00:00
abstract：:It was established that stimulation of the lateral hypothalamus (LH) can induce antinociception. Previous studies showed a role for the ventral tegmental area (VTA) and nucleus accumbens (NAc) in antinociception induced by LH stimulation through the orexinergic system. In this study, we tried to assess the involvement...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2015.05.047
更新日期：2015-07-10 00:00:00
abstract：:The effects have been investigated of anesthetic and convulsant barbiturates on the spontaneous and potassium-stimulated efflux of [3H]D-aspartate from rat cortex minislices. In concentrations (100 microM) which have previously been shown to alter calcium ATPase activity in synaptosomes, anaesthetic barbiturates depre...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(80)90324-9
更新日期：1980-06-01 00:00:00
abstract：:Distributions of 25 motor axons to 60 intrafusal muscle fibers of 10 poles of monkey spindle were reconstructed from serial 1 micron thick transverse sections of lumbrical muscles. About 44% of motor axons co-innervated two or more types of intrafusal fiber. The (dynamic) bag1 fiber shared motor innervation with the (...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(85)90092-8
更新日期：1985-01-07 00:00:00
abstract：:Previous studies on the effects of serotonin receptor 1A (5-HT1A) gene variation on treatment response in depression revealed inconsistent results with studies pointing towards a detrimental influence of the 5-HT1A-1019G allele on antidepressant treatment response, while others did not discern any involvement of 5-HT1...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.03.001
更新日期：2008-05-09 00:00:00
abstract：:In a light microscopic study the ferric ion-ferrocyanide staining of the squid giant axon was investigated. In other neurons this stain is known to indicate excitable membranes with high sodium channel density, such as the node of Ranvier or the initial segment. In the squid the stain reacted in small patches of the a...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(85)90055-2
更新日期：1985-06-12 00:00:00
abstract：:To determine whether diabetes mellitus alters the lipid order and composition of cerebral microvessels, streptozotocin-induced diabetic rats were studied after 5 weeks of chronic hyperglycemia. Diabetes did not affect membrane order or the thermotropic transition temperature of cerebral microvessels as determined from...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(92)90007-t
更新日期：1992-10-12 00:00:00
abstract：:The pigment of human substantia nigra, neuromelanin, has been thought to be derived from dopamine. To examine the genesis of neuromelanin, we advanced a new hypothesis that neuromelanin is formed by oxidation of dopamine and cysteinyldopamine. On the basis of this hypothesis, synthetic neuromelanins were obtained by t...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(91)90336-r
更新日期：1991-09-30 00:00:00
abstract：:Noradrenaline in the central nervous system plays an important role in regulating physiological functions, and is a key mechanistic component of general anesthesia. The purpose of this present study was to determine if nitrous oxide and xenon modulate noradrenaline release in the cerebral cortex. We performed a series...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2009.11.074
更新日期：2010-01-22 00:00:00
abstract：:The effect of partial isomerization of dietary alpha-linolenic acid on the monoaminergic neurotransmitters in piglets was studied. After feeding the animals for 14 days with diets containing or not trans alpha-linolenic acid, neurotransmitters related to the monoaminergic function were quantified in the frontal cortex...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(02)00879-0
更新日期：2002-10-18 00:00:00
abstract：:While alpha- and beta-synuclein largely overlap in their expression in the vertebrate brain, only alpha-synuclein accumulates in the fibrillar aggregates typical of Parkinson's disease. It is thus critical to have immunological reagents that distinguish between these two protein isoforms. The monoclonal antibody Syn-1...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(03)00781-x
更新日期：2003-10-02 00:00:00
abstract：:Single-site variants in the calmodulin-binding domain of RC3/neurogranin were heterologously expressed in Xenopus oocytes to examine their effects on serotonin-evoked currents. RC3 variants serine36 -->alanine (Ser36-->Ala), serine36-->glycine (Ser36-->Gly), and phenylalanine37-->tryptophan (Phe37-->Trp), which bind c...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(96)13203-1
更新日期：1996-11-29 00:00:00
abstract：:Suicide is a major contributor to the morbidity and mortality of schizophrenia, accounting for approximately 10% of deaths in these patients. Genetic factors have been reported to modulate the risk for suicide, although the precise mechanism and magnitude of the genetic contribution are unknown. Further, suicide attem...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2010.11.079
更新日期：2011-02-11 00:00:00
abstract：:We determined the effect of naloxone and morphine on the differentiation of pheochromocytoma cell, the PC12 cells, induced by nerve growth factor (NGF). PC12 cells were grown in medium containing NGF with or without the addition of naloxone or morphine for up to 10-day treatments. NGF-induced morphological differentia...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(98)00528-x
更新日期：1998-08-07 00:00:00
abstract：:Spontaneous openings of acetylcholine receptor channels were investigated using Xenopus myotomal muscle cells in culture and patch clamp recording methods. Two classes of channels with conductances close to 40 and 60 pS and reversal potentials near 0 mV were found to open in the absence of agonist. The open time of th...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(91)90092-8
更新日期：1991-04-01 00:00:00
abstract：:We analyzed event-related potential (ERP) correlates of numerical and alphabetical positional judgements. Sixteen subjects classified whether acoustically presented numbers (1, 4, 6 or 9) were smaller or larger than 5 or whether phonemes (a, d, f or i) stood before or after letter 'e' in the alphabet. Stimulus non-spe...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.02.038
更新日期：2004-04-22 00:00:00
abstract：:An anti-Fos protein antiserum was used to elucidate the diurnal expression of Fos protein in the normal and degenerate rd/rd mice retina. We have found that Fos expression is stimulated in cells of both inner nuclear layer (INL) and ganglion cell layer (GCL) at the onset of light period and reaches its maximum after 2...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(97)00595-8
更新日期：1997-09-05 00:00:00
abstract：:Cerebrospinal fluid concentration of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) was measured in normal developing rat from birth to postnatal day (PND) 21 by enzyme-linked immunosorbent assay. NGF levels were significantly higher than those of BDNF and NT-3 from PND ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(00)00782-5
更新日期：2000-02-25 00:00:00
abstract：:Outcome following traumatic brain injury (TBI) is in large part determined by the combined action of multiple processes. In order to better understand the response of the central nervous system to injury, we utilized an antibody array to simultaneously screen 507 proteins for altered expression in the injured hippocam...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2006.11.060
更新日期：2007-02-08 00:00:00
