Cysteinyldopamine is not incorporated into neuromelanin.

abstract：:Neurodegenerative disorders such as Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are characterized by impairment of autophagy. Cellular survival is dependent on efficient clearance of phosphorylated α-synuclein, which accumulates as fibrils in the neuronal cytoplasm as Lewy bodies (LBs). The forkhead b...

journal_title：Neuroscience letters

authors： Miki Y,Tanji K,Mori F,Utsumi J,Sasaki H,Kakita A,Takahashi H,Wakabayashi K

更新日期：2018-09-25 00:00:00

abstract：:The binding of the lectin soybean agglutinin (SBA) to the olfactory system of both the rat and mouse was investigated histochemically. SBA bound to fibers in the accessory olfactory nerve and to glomeruli in the accessory olfactory bulb. In addition, SBA binding sites were present in some, but not all, glomeruli in th...

journal_title：Neuroscience letters

authors： Key B,Giorgi PP

更新日期：1986-08-29 00:00:00

abstract：:In the injured brain, astrocytes become activated and increase GFAP expression; a phenomenon termed as astrogliosis. Previously, we have reported that DJ-1, a Parkinson's disease gene, positively regulates astrogliosis in the injured brain. Moreover, STAT3 is known to play a key role in the regulation of astrogliosis....

journal_title：Neuroscience letters

authors： Choi DJ,Kwon JK,Joe EH

更新日期：2018-10-15 00:00:00

abstract：:Rats with suprachiasmatic nuclei (SCN) lesions did not show increased sleep after triazolam (TRZ) injections at any dose from 0.2 to 1.6 mg/kg, whereas 0.4 mg/kg TRZ given intact rats in the middle of their activity phase significantly increased sleep. Across SCN-lesioned and intact rats, the amount of sleep before an...

journal_title：Neuroscience letters

authors： Edgar DM,Seidel WF,Martin CE,Sayeski PP,Dement WC

更新日期：1991-04-29 00:00:00

abstract：:The fine structure of striato-nigral efferent neurons, retrogradely labeled with HRP, was studied. The neuron showed a medium sized ovoid or tri-angular perikaryon. Short or medium lengthened granular endoplasmic reticula, having a tendency to wind and pile up in stacks were observed. This neurons corresponds to a typ...

journal_title：Neuroscience letters

authors： Kaiya H,Okinaga M,Namba M,Shoumura K,Watanabe S

更新日期：1979-09-01 00:00:00

abstract：:δ-Catenin is a component of the cadherin-catenin cell adhesion complex and its loss has been implicated in the mental retardation associated with the Cri du chat syndrome. We have previously demonstrated that loss of δ-catenin in a murine model during development results in excessive spine and synaptic density and fun...

journal_title：Neuroscience letters

authors： Yuan Y,Singh D,Arikkath J

更新日期：2013-03-01 00:00:00

abstract：:Recombinant retroviruses containing the cDNA for human tyrosine hydroxylase-1 and Escherichia coli lacZ gene were used to infect primary foetal ventral mesencephalon and cortical cultures from rat brain. Severe neuronal toxicity resulted 3-4 days after infection, glial cells seemed to be much more resistant. The toxic...

journal_title：Neuroscience letters

authors： Hurley MJ,Bradford HF,O'Hare K,Stern GM,Uchida K

更新日期：1996-12-06 00:00:00

abstract：:During horizontal optokinetic stimulation (moving random dot pattern) in freely standing cats, gaze, head, and eye movements were measured with the search coil technique. The position values ('beating field') were evaluated. Gaze position depended on stimulus direction and stimulus velocity; it shifted to where the st...

journal_title：Neuroscience letters

authors： Schweigart G

更新日期：1995-01-02 00:00:00

abstract：:The rat spinal cord slice preparation has been used to investigate the sensitivity of deep dorsal horn neurones to the excitatory amino acids N-methyl-D-aspartate (NMDA), quisqualate and L-glutamate. Intracellular recordings were made from 44 neurones in laminae III-VI of 14- to 16-day rats. Superfusion of quisqualate...

journal_title：Neuroscience letters

authors： King AE,Thompson SW,Urban L,Woolf CJ

更新日期：1988-07-08 00:00:00

abstract：:Changes in the activity of gamma-glutamyl transpeptidase (GGTP) and the effects of a subacute dose (150 mg/kg b.wt.) of methionine sulfoximine (MSO) on its activity were studied in cerebral cortex, cerebellum and brainstem of rats of 4 different age groups. GGTP activity increased with increasing age between days 10 a...

journal_title：Neuroscience letters

authors： Rao VL,Murthy CR

更新日期：1991-05-13 00:00:00

abstract：:Abnormal myelin gene expression in the central nervous system (CNS) is associated with many mental illnesses, including psychiatric disorders and drug addiction. We have previously shown that prenatal exposure to nicotine, the major psychoactive component in cigarette smoke, alters myelin gene expression in the CNS of...

journal_title：Neuroscience letters

authors： Cao J,Dwyer JB,Gautier NM,Leslie FM,Li MD

更新日期：2013-10-11 00:00:00

abstract：:Based on its proposed ability to block the effect of selective serotonin reuptake inhibitors (SSRIs) on the firing rate of serotonergic neurons, the 5-HT1A partial agonist/beta-adrenergic antagonist pindolol has been examined in clinical trials for its ability to enhance the efficacy of SSRIs. However, varying results...

journal_title：Neuroscience letters

authors： Rasmussen K,McCreary AC,Shanks EA

更新日期：2004-01-23 00:00:00

abstract：:In 16 rats, the extensor digitorum longus (EDL) - a fast muscle - was grafted, complete with its innervation, into the bed of the (removed) soleus - a slow muscle. Following the transposition, performed on one side only, EDL recovered and showed the contraction time of the contralateral EDL that served as control. How...

journal_title：Neuroscience letters

authors： Gutmann E

更新日期：1976-07-01 00:00:00

abstract：:Genetic factors play an important role in Parkinson's disease (PD) and vary from different races. A previous genome-wide association study (GWAS) identified 17 novel risk loci that were associated with PD in Caucasians. Several subsequent studies investigated the association between these loci and PD in Chinese popula...

journal_title：Neuroscience letters

authors： Hu X,Mao C,Hu Z,Zhang Z,Zhang S,Yang Z,Fan Y,Fan L,Zheng H,Yang J,Liu Y,Yuan Y,Wang Y,Shi C,Xu Y

更新日期：2020-04-23 00:00:00

abstract：:Chronic stress is well known to exacerbate pain. We tested the hypothesis that neonatal handling, which induces resilience to the negative impact of stress by increasing the quality and quantity of maternal care, attenuates the mechanical hyperalgesia produced by water-avoidance stress in the adult rat. Neonatal male ...

journal_title：Neuroscience letters

authors： Alvarez P,Levine JD,Green PG

更新日期：2015-03-30 00:00:00

abstract：:The biological clock of the suprachiasmatic nuclei drives numerous physiological and behavioural circadian rhythms. In this study, we addressed the question as to whether different components of the clock may control separately various circadian functions. Using the rat transpineal microdialysis tool, we analysed the ...

journal_title：Neuroscience letters

authors： Tritschler L,Saboureau M,Pévet P,Bothorel B

更新日期：2006-03-20 00:00:00

abstract：:The nucleus of the basal optic root (nBOR) is involved in the generation of the optokinetic response. Previous studies showed that most nBOR neurons exhibit direction-selectivity in response to largefield motion. We investigated the responses of pigeon nBOR neurons to drifting sine wave gratings of varying spatial and...

journal_title：Neuroscience letters

authors： Crowder NA,W Wylie DR

更新日期：2001-05-25 00:00:00

abstract：:l-Carnosine (β-alanyl-l-histidine), a dipeptide of the amino acids β-alanine and histidine, is found in mammalian tissues including those in the central nervous system and in skeletal muscles. In the present study, we examined the effects of intraduodenal (ID) injection of l-carnosine on splenic sympathetic nerve acti...

journal_title：Neuroscience letters

authors： Horii Y,Shen J,Fujisaki Y,Yoshida K,Nagai K

更新日期：2012-02-21 00:00:00

abstract：:The central projection of vestibular nerve fibers was investigated with anterograde axonal transport of wheatgerm agglutinin-horseradish peroxidase (WGA-HRP) and tritiated leucine following injection in the vestibular ganglion. Labeled fibers and terminal ramifications were observed throughout the vestibular complex, ...

journal_title：Neuroscience letters

authors： Gerrits NM,Epema AH,van Linge A,Dalm E

更新日期：1989-10-23 00:00:00

abstract：:Several evidences have pointed to biochemical alterations in some brain structures after experimental Status Epilepticus (SE). Thus, the effects of pilocarpine-induced SE on the glutamate binding in the hippocampus and cortex of Wistar rats were evaluated. Groups of animals were submitted to a 3h SE induced by intrahi...

journal_title：Neuroscience letters

authors： Cunha AO,Mortari MR,Carolino RO,Coutinho-Netto J,Dos Santos WF

更新日期：2007-08-31 00:00:00

abstract：:The effects of myelin basic protein (MBP) on the ventral root response in rat spinal cord in situ and on the spontaneous bioelectric activity of cultured rat Purkinje cells were investigated. Injection of 2 or 4 microl MBP (10(-4) M/l) into the motoneurone pool reduced the ventral root response to dorsal root stimulat...

journal_title：Neuroscience letters

authors： Honegger CG,Gähwiler BH,Isler H

更新日期：1977-05-01 00:00:00

abstract：:To assess cortical activity during pain perception, regional cerebral blood flow (rCBF) studies were done in humans using single photon emission computed tomography (SPECT) with the radiotracer Tc99m-HMPAO and magnetic resonance imaging localization. Normalized SPECT data were analyzed by region of interest and change...

journal_title：Neuroscience letters

authors： Apkarian AV,Stea RA,Manglos SH,Szeverenyi NM,King RB,Thomas FD

更新日期：1992-06-22 00:00:00

abstract：:Differential performance over a wide range of possible postural coordination modes was investigated using 16 ankle-hip relative phase patterns from 0 degrees to 337.5 degrees. Participants were instructed to produce each coordination mode with and without real time visual feedback. Feedback consisted of a Lissajous fi...

journal_title：Neuroscience letters

authors： Faugloire E,Bardy BG,Merhi O,Stoffregen TA

更新日期：2005-02-10 00:00:00

abstract：:We investigated the effects of a representative anti-epileptic or anti-psychotic drug, carbamazepine (CBZ), on the induction of long-term potentiation (LTP) in the perforant path-dentate gyrus pathway in 15 chronically prepared rabbits. Pharmacokinetically injected low-dose CBZ, which produced steady serum levels of 2...

journal_title：Neuroscience letters

authors： Kubota T,Jibiki I,Fukushima T,Kurokawa K,Yamaguchi N

更新日期：1994-03-28 00:00:00

abstract：:Infection of the snail Lymnaea stagnalis with the schistosome parasite Trichobilharzia ocellata results in inhibition of reproduction and in giant growth. Parasite-related effects on the neuroendocrine centres that control these processes were studied electrophysiologically. Haemolymph from infected snails reduced the...

journal_title：Neuroscience letters

authors： Hordijk PL,de Jong-Brink M,ter Maat A,Pieneman AW,Lodder JC,Kits KS

更新日期：1992-03-02 00:00:00

abstract：:Neuromelanin (NM)-containing dopaminergic neurons in the substantia nigra are selectively vulnerable in Parkinson's disease (PD), suggesting the involvement of NM in the pathogenesis. NM is composed of protein, lipid, trace metals and melanin component, a mixture of eumelanin produced from dopamine (DA)-quinone and ph...

journal_title：Neuroscience letters

authors： Naoi M,Yi H,Maruyama W,Inaba K,Shamoto-Nagai M,Akao Y,Gerlach M,Riederer P

更新日期：2009-11-13 00:00:00

abstract：:There is little information available on the mechanisms underlying the neuroprotective actions of the organoselenium compound ebselen. In this study, we sought to determine the relationship between alterations in the expression of Bcl-2 and Bax proteins and intracellular levels of calcium and the protective effects of...

journal_title：Neuroscience letters

authors： Xu JH,Hu HT,Liu Y,Qian YH,Liu ZH,Tan QR,Zhang ZJ

更新日期：2006-05-22 00:00:00

abstract：:Afferent baroreceptor information is transmitted to the nucleus tractus solitarius (NTS) in the dorsal medulla where glutamate is thought to be the primary neurotransmitter. However, the subtypes of glutamate receptors involved in the baroreflex remain to be established. The present study compared the distribution of ...

journal_title：Neuroscience letters

authors： Botsford SA,Dean C,Hopp FA,Seagard JL

更新日期：1999-02-12 00:00:00

abstract：:Noradrenaline (NA)- and neuropeptide Y (NPY)-containing cell bodies were found to occur in high numbers (>75% of all cells were positive) in the human superior cervical ganglion and distributed homogeneously throughout the ganglion and showed colocalisation. A few cell bodies were VIP-immunoreactive (-ir) (less than 5...

journal_title：Neuroscience letters

authors： Tajti J,Möller S,Uddman R,Bodi I,Edvinsson L

更新日期：1999-03-26 00:00:00

abstract：:We examined the caudate spindle in control and pargyline-pretreated rats following bilateral application of 3 doses (15, 50 and 150 micrograms/site) of dopamine (DA) into the caudate nucleus. The highest dose of DA (150 micrograms) suppressed the spindle, whereas lower doses (15, 50 micrograms) enhanced the spindle in...

journal_title：Neuroscience letters

authors： Okuyama S,Hashimoto S,Aihara H

更新日期：1985-08-16 00:00:00