Abstract:
:Cerebrospinal fluid concentration of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) was measured in normal developing rat from birth to postnatal day (PND) 21 by enzyme-linked immunosorbent assay. NGF levels were significantly higher than those of BDNF and NT-3 from PND 1-21. NGF levels decreased from PND 1-3 to PND 9. At PND 15 and 17, NGF levels peaked a second time and rapidly decreased to PND 21. BDNF peaked at PND 13-15, while NT-3 levels peaked at PND 7-9. Each of the three neurotrophins has its own characteristic pattern in changes in cerebrospinal fluid levels.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Xia YX,Ikeda T,Xia XY,Ikenoue Tdoi
10.1016/s0304-3940(00)00782-5keywords:
subject
Has Abstractpub_date
2000-02-25 00:00:00pages
220-2issue
3eissn
0304-3940issn
1872-7972pii
S0304394000007825journal_volume
280pub_type
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