Differential neurotrophin levels in cerebrospinal fluid and their changes during development in newborn rat.

Abstract:

:Cerebrospinal fluid concentration of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) was measured in normal developing rat from birth to postnatal day (PND) 21 by enzyme-linked immunosorbent assay. NGF levels were significantly higher than those of BDNF and NT-3 from PND 1-21. NGF levels decreased from PND 1-3 to PND 9. At PND 15 and 17, NGF levels peaked a second time and rapidly decreased to PND 21. BDNF peaked at PND 13-15, while NT-3 levels peaked at PND 7-9. Each of the three neurotrophins has its own characteristic pattern in changes in cerebrospinal fluid levels.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Xia YX,Ikeda T,Xia XY,Ikenoue T

doi

10.1016/s0304-3940(00)00782-5

keywords:

subject

Has Abstract

pub_date

2000-02-25 00:00:00

pages

220-2

issue

3

eissn

0304-3940

issn

1872-7972

pii

S0304394000007825

journal_volume

280

pub_type

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