Abstract：
:It is debated whether non-affected relatives of patients with affective disorders share a specific brain structure endophenotype. Aim of this work is to explore the medial temporal morphology in affected and non-affected members of a family with mood disorders. Hippocampi and amygdalae were manually traced from the 3D magnetic resonance imaging of five affected family members, 10 non-affected relatives, and 15 unrelated matched controls. Affected and non-affected relatives were characterized by larger left amygdalae (18%, p=0.030), smaller right hippocampus (up to 18%, p<0.0005), and reduced hippocampal asymmetry (p<0.001) than controls. Abnormal, albeit non significant, positive correlations of MTL volumes with age were observed, with the exception of smaller volume of the left hippocampus with advancing age (r=-0.76) in the affected relatives. These data add to the evidence that abnormal medial temporal structures may constitute an endophenotype for affective disorders.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Boccardi M,Almici M,Bresciani L,Caroli A,Bonetti M,Monchieri S,Gennarelli M,Frisoni GBdoi
10.1016/j.neulet.2009.10.067subject
Has Abstractpub_date
2010-01-04 00:00:00pages
93-7issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(09)01412-8journal_volume
468pub_type
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