Abstract:
:Capsaicin, a neurotoxin which impairs some primary afferent nerve fibers, was locally applied to the mesenteric nerve trunks of adult guinea pigs. The effect of capsaicin was studied on contractile responses of the ileum to mesenteric nerve stimulation (20 Hz). Exposure of the mesenteric nerve to capsaicin (1 microM) irreversibly abolished the contractile response to mesenteric nerve stimulation, without influencing the resting tension and spontaneous motility of the ileum. However, if the mesenteric nerve had been incubated in a Ca-free medium containing EGTA (0.1 mM) or pretreated with Ruthenium red (10 microM), capsaicin only partially inhibited (about 30%), but did not abolish, the contractile response to the mesenteric nerve stimulation, thus indicating protection from desensitization.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Jin JG,Takaki M,Nakayama Sdoi
10.1016/0304-3940(89)90218-8subject
Has Abstractpub_date
1989-11-20 00:00:00pages
152-6issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(89)90218-8journal_volume
106pub_type
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