Ruthenium red prevents capsaicin-induced neurotoxic action on sensory fibers of the guinea pig ileum.

Abstract:

:Capsaicin, a neurotoxin which impairs some primary afferent nerve fibers, was locally applied to the mesenteric nerve trunks of adult guinea pigs. The effect of capsaicin was studied on contractile responses of the ileum to mesenteric nerve stimulation (20 Hz). Exposure of the mesenteric nerve to capsaicin (1 microM) irreversibly abolished the contractile response to mesenteric nerve stimulation, without influencing the resting tension and spontaneous motility of the ileum. However, if the mesenteric nerve had been incubated in a Ca-free medium containing EGTA (0.1 mM) or pretreated with Ruthenium red (10 microM), capsaicin only partially inhibited (about 30%), but did not abolish, the contractile response to the mesenteric nerve stimulation, thus indicating protection from desensitization.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Jin JG,Takaki M,Nakayama S

doi

10.1016/0304-3940(89)90218-8

subject

Has Abstract

pub_date

1989-11-20 00:00:00

pages

152-6

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(89)90218-8

journal_volume

106

pub_type

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