Abstract:
:The expression of neuronal nicotinic acetylcholine receptors (nAChRs) influenced by lipid peroxidation has been investigated. The results showed that exposure of PC12 cells to a free radical insult (FeSO(4)) induced concentration-dependent increase in level of MDA (malondialdehyde), and a significant decline in MTT [3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide] reduction. In cultured cells exposed to FeSO(4), a significant dose-dependent decrease in [(3)H] epibatidine binding sites was detected and a significant reduction in B(max) value was observed in the high affinity epibatidine binding site. These results demonstrate that lipid peroxidation in cellular membranes can induce a reduction in numbers of neuronal nAChRs.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Guan Z,Zhang X,Nordberg Adoi
10.1016/s0304-3940(00)01127-7keywords:
subject
Has Abstractpub_date
2000-06-09 00:00:00pages
163-6issue
3eissn
0304-3940issn
1872-7972pii
S0304394000011277journal_volume
286pub_type
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