Abstract:
:Synaptic vesicle fusion events are essential for synaptic transmission. Membrane docking and fusion events are highly regulated processes requiring the participation of a large number of soluble N-ethylmaleimide-sensitive factors (SNAREs) and SNARE-interacting proteins. We report the neuronal expression of mammalian homologue of vacuolar protein sorting 16 (mVps16p) which exhibits a high homology to the yeast Vps16p, a component of Class C Vps. Western blot and immunohistochemical analyzes revealed that mVps16p is highly expressed in the various brain areas and developmental stages tested. The immunoreactivities of mVps16p colocalized with microtubule associated protein 2, but not glial fibrillary acidic protein. In the primary culture of cortical neurons, mVps16p immunoreactivities were observed in the cell body and the neuronal processes, and highly enriched in the axonal outgrowths.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Kim BY,Ueda M,Nakamura Y,Kohsaka S,Akazawa Cdoi
10.1016/j.neulet.2003.11.021keywords:
subject
Has Abstractpub_date
2004-01-30 00:00:00pages
217-20issue
3eissn
0304-3940issn
1872-7972pii
S0304394003013351journal_volume
355pub_type
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