当前位置： SCI文献检索 > NEUROSCIENCE LETTERS期刊下所有文献 > Nitric oxide facilitates N-methyl-D-aspartate-induced burst firing in dopamine neurons from rat midbrain slices.

Nitric oxide facilitates N-methyl-D-aspartate-induced burst firing in dopamine neurons from rat midbrain slices.

Abstract：

:Dopamine (DA) neurons in the ventral tegmental area and substantia nigra pars compacta were induced to fire in bursts with application of N-methyl-D-aspartate (NMDA, 20 microM) and apamin (100 nM) while recording intracellularly in the rat brain slice. L-Arginine (300 microM), a substrate for nitric oxide (NO) production, increased both the number of spikes per burst and the magnitude of interburst hyperpolarizations. Nitric oxide synthase inhibitors N-nitro-L-arginine methyl ester (L-NAME, 100 microM), N-nitro-L-arginine, and 7-nitroindazole inhibited NMDA-induced burst firing by reducing the number of spikes per burst. Moreover, L-arginine (100 microM) reversed the inhibition of burst firing produced by L-NAME. These findings suggest that NO facilitates NMDA-induced burst firing in DA neurons.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Cox BA,Johnson SW

doi

10.1016/s0304-3940(98)00737-x

subject

Has Abstract

pub_date

1998-10-23 00:00:00

pages

131-4

issue

3

eissn

0304-3940

issn

1872-7972

pii

S030439409800737X

journal_volume

255

pub_type

杂志文章

相关文献

NEUROSCIENCE LETTERS文献大全
  • Regulation of the voltage-gated Ca2+ channel CaVα2δ-1 subunit expression by the transcription factor Egr-1.

    abstract：:It is well known that the CaVα2δ auxiliary subunit regulates the density of high voltage-activated Ca2+ channels in the plasma membrane and that alterations in their functional expression might have implications in the pathophysiology of diverse human diseases such as neuropathic pain. However, little is known concern...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2018.03.005

    authors： González-Ramírez R,Martínez-Hernández E,Sandoval A,Gómez-Mora K,Felix R

    更新日期：2018-04-23 00:00:00

  • RNAi blocks DYT1 mutant torsinA inclusions in neurons.

    abstract：:Early onset generalized dystonia is a dominantly inherited movement disorder caused by neuronal dysfunction without an apparent loss of neurons. The same single mutation (GAG deletion) causes most cases and results in loss of a glutamic acid (E) in the carboxy terminal region of torsinA (Delta302/303). To model the ne...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2005.10.098

    authors： Kock N,Allchorne AJ,Sena-Esteves M,Woolf CJ,Breakefield XO

    更新日期：2006-03-13 00:00:00

  • Sustained phosphorylation and activation of protein kinase B correlates with brain-derived neurotrophic factor and insulin stimulated survival of cerebellar granule cells.

    abstract：:Brain-derived neurotrophic factor (BDNF) and insulin promote the survival of 6-7 day old post-natal rat cerebellar granule cells. Previous studies using the PI3 kinase inhibitor, wortmannin and the over-expression of protein kinase B (PKB) have indicated that both PI3 kinase and PKB activation are central for insulin-...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(99)00166-4

    authors： Foulstone EJ,Tavaré JM,Gunn-Moore FJ

    更新日期：1999-04-02 00:00:00

  • Corticospinal excitability during painful self-stimulation in humans: a transcranial magnetic stimulation study.

    abstract：:We investigated changes in the corticospinal pattern of activity in healthy volunteers during sustained noxious and non-noxious mechanical stimulation of the first hand digit, resulting from active (self-stimulation) or passive (externally-induced) pressing against a sharp or blunted tip. The results indicate that, in...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2003.12.016

    authors： Fadiga L,Craighero L,Dri G,Facchin P,Destro MF,Porro CA

    更新日期：2004-05-06 00:00:00

  • Association of the CR1 polymorphism with late-onset Alzheimer's disease in Chinese Han populations: a meta-analysis.

    abstract：:It is well known that genetic variants play a critical role in the pathogenesis of Alzheimer's disease (AD). In 2009, a genome-wide association study (GWAS) demonstrated that a single nucleotide polymorphism (SNP), rs6656401, in complement receptor 1 (CR1) is significantly associated with late-onset Alzheimer's diseas...

    journal_title：Neuroscience letters

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.neulet.2012.08.032

    authors： Jin C,Li W,Yuan J,Xu W,Cheng Z

    更新日期：2012-10-03 00:00:00

  • Neuritogenic activity of peripheral nerve myelin proteins in Lewis rats.

    abstract：:The neuritogenic activity of human peripheral nerve myelin proteins in Lewis rats was examined. Experimental allergic neuritis (EAN) was induced by human myelin fraction in all Lewis rats examined. Purified human P2 protein induced mild but definite EAN. None of purified P0 protein, total myelin lipids, gangliosides a...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(80)90287-6

    authors： Suzuki M,Kitamura K,Uyemura K,Ogawa Y,Ishihara Y,Matsuyama H

    更新日期：1980-10-02 00:00:00

  • In vivo activation and in situ BDNF-stimulated nuclear translocation of mitogen-activated/extracellular signal-regulated protein kinase is inhibited by ethanol in the developing rat hippocampus.

    abstract：:In order to test the hypothesis that ethanol (EtOH)-induced changes in growth factor signal transduction contribute to the teratogenic effects of EtOH in the developing brain, neonatal rat pups were administered a single dose of EtOH during the brain growth spurt (5 days of age, PN5). Hippocampal mitogen-activated/ext...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(99)00572-8

    authors： Davis MI,Szarowski D,Turner JN,Morrisett RA,Shain W

    更新日期：1999-09-10 00:00:00

  • Detection of 5-HT3R-A, a 5-HT3 receptor subunit, in submucosal and myenteric ganglia of rat small intestine using in situ hybridization.

    abstract：:Physiological and radioligand binding studies have demonstrated the existence of 5-HT3 receptors in the enteric nervous system. In order to determine if the cloned 5-HT3 receptor subunit, 5-HT3R-A, was expressed in the enteric nervous system of rats, we have performed in situ hybridization with 33P-labeled cRNA antise...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(94)11170-n

    authors： Johnson DS,Heinemann SF

    更新日期：1995-01-16 00:00:00

  • Preparation of an antiserum using a fusion protein produced by a cDNA for rat aromatic L-amino acid decarboxylase.

    abstract：:Aromatic L-amino acid decarboxylase (AADC) decarboxylates L-DOPA and 5-hydroxytryptophan into dopamine and serotonin, respectively. Starting from a rat AADC cDNA clone isolated in our laboratory, we produced a beta-galactosidase-AADC fusion protein in E. coli. It was purified from inclusion bodies and injected into a ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(93)90084-x

    authors： Krieger M,Tillet Y,Gros F,Thibault J

    更新日期：1993-04-16 00:00:00

  • The maturation of post-synaptic densities in chicken forebrain.

    abstract：:During normal post-hatch development and maturation in chicken forebrain there was a doubling in the average thickness of the post-synaptic densities (PSDs) in isolated synaptosomes, but no change in the average length of synaptic junctions. In the same period the concentration of the major post-synaptic density prote...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(84)90242-8

    authors： Rostas JA,Brent VA,Güldner FH

    更新日期：1984-04-06 00:00:00

  • Cerebrospinal fluid levels of alpha-tocopherol in patients with multiple sclerosis.

    abstract：:We compared cerebrospinal fluid (CSF) and serum levels, and the CSF/serum ratio of alpha-tocopherol (vitamin E), measured by HPLC, in 36 patients with multiple sclerosis (MS) and 32 matched controls. The mean CSF vitamin E levels and the CSF/serum vitamin E ratio did not differ significantly between the two study grou...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(98)00370-x

    authors： Jiménez-Jiménez FJ,de Bustos F,Molina JA,de Andrés C,Gasalla T,Ortí-Pareja M,Zurdo M,Porta J,Castellano-Millán F,Arenas J,Enríquez de Salamanca R

    更新日期：1998-06-12 00:00:00

  • Pragmatic inferences modulate N400 during sentence comprehension: evidence from picture-sentence verification.

    abstract：:The present study examines the online realization of pragmatic meaning using event-related potentials (ERPs). Participants read sentences including the English quantifier some, which has both a semantic meaning (at least one) and a pragmatic meaning (not all). Unlike previous ERP studies of this phenomenon, sentences ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2012.11.044

    authors： Hunt L 3rd,Politzer-Ahles S,Gibson L,Minai U,Fiorentino R

    更新日期：2013-02-08 00:00:00

  • Glyphosate exposure exacerbates the dopaminergic neurotoxicity in the mouse brain after repeated administration of MPTP.

    abstract：:Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder. Epidemiological studies suggest that the exposure of the herbicide glyphosate may influence the development of PD in humans. In this study, we examined whether the exposure of glyphosate can affect the reduction of dopamine transporter (...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2020.135032

    authors： Pu Y,Chang L,Qu Y,Wang S,Tan Y,Wang X,Zhang J,Hashimoto K

    更新日期：2020-06-21 00:00:00

  • Induction of giant depolarizing potentials by zinc in area CA1 of the rat hippocampus does not result from block of GABAB receptors.

    abstract：:The possibility that zinc (Zn2+) induces giant depolarizing potentials (GDPs) by blocking pre- and postsynaptic gamma-aminobutyric acidB (GABAB) receptors in area CA1 of rat hippocampal slices was investigated. Monosynaptic GABAA receptor-mediated fast and GABAB receptor-mediated late inhibitory postsynaptic potential...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(92)90439-e

    authors： Lambert NA,Levitin M,Harrison NL

    更新日期：1992-02-03 00:00:00

  • Morphine does not reduce the intraspinal release of calcitonin gene-related peptide in the cat.

    abstract：:In anaesthetised cats, antibody microprobes were used to measure the release of immunoreactive calcitonin gene-related peptide (irCGRP) in the lumbar dorsal horn during stimulation of non-nociceptive or nociceptive primary afferent fibres. Release of irCGRP was detected in the substantia gelatinosa, where immunostaini...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(90)90684-2

    authors： Morton CR,Hutchison WD

    更新日期：1990-09-18 00:00:00

  • Ontogenesis of the pinealo-retinal neuronal connection in albino rats.

    abstract：:It was accepted for a long time that in mammals there is only retinofugal neuronal connection between the eye and the pineal body (PB). In our previous paper we described that nerve cells were present in hamster PB and these neurons could establish a reverse connection with the retina through a transsynaptic pathway. ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2017.12.007

    authors： Csáki Á,Vereczki V,Lukáts Á,Boldogkői Z,Sebestyén A,Puskár Z,Köves K

    更新日期：2018-02-05 00:00:00

  • Does barbiturate anesthesia modify the neuronal properties of the somatosensory thalamus? A single-unit study related to nociception in the awake-pentobarbital-treated rat.

    abstract：:By means of extracellular recordings, we studied thalamic ventrobasal complex neurons of rats tested first awake, and then anesthetized with pentobarbital. In both conditions, we found two groups of units in both states. The first group, displaying a spontaneous bursting activity, was not obviously responding to perip...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(95)11847-p

    authors： Montagne-Clavel J,Olivéras JL

    更新日期：1995-08-18 00:00:00

  • Genistein enhances proteasomal degradation of the short isoform of FLIP in malignant glioma cells and thereby augments TRAIL-mediated apoptosis.

    abstract：:Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising cancer drug. One obstacle in TRAIL-based therapies is that many cancer cells, including gliomas, are resistant towards TRAIL. In this study one glioblastoma cell line, one human short-term glioblastoma culture and human astrocytes were tre...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2009.02.018

    authors： Siegelin MD,Siegelin Y,Habel A,Gaiser T

    更新日期：2009-04-03 00:00:00

  • Voluntary resistance running induces increased hippocampal neurogenesis in rats comparable to load-free running.

    abstract：:Recently, we reported that voluntary resistance wheel running with a resistance of 30% of body weight (RWR), which produces shorter distances but higher work levels, enhances spatial memory associated with hippocampal brain-derived neurotrophic factor (BDNF) signaling compared to wheel running without a load (WR) [17]...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2013.01.005

    authors： Lee MC,Inoue K,Okamoto M,Liu YF,Matsui T,Yook JS,Soya H

    更新日期：2013-03-14 00:00:00

  • Benzodiazepine receptors are not involved in the neurotoxicity and anti-electroshock activity of phenytoin in mice.

    abstract：:The present study was undertaken to investigate whether benzodiazepine receptors are involved in either the anticonvulsant activity of phenytoin against supramaximal seizures or maximal threshold seizures induced by electroshock or the neurotoxicity of phenytoin. Ro 15-1788, a benzodiazepine receptor antagonist, rever...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(85)90505-1

    authors： Chweh AY,Swinyard EA,Wolf HH

    更新日期：1985-06-24 00:00:00

  • Changes in human diaphragmatic electromyogram with positive pressure breathing.

    abstract：:An increase in diaphragmatic electromyogram (EMG) recorded via oesophageal electrodes during positive pressure breathing has been reported to indicate an increase in the neural outflow to the muscle. However, using similar techniques, the size of compound muscle action potentials produced by supramaximal phrenic nerve...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(86)90442-8

    authors： McKenzie DK,Gandevia SC

    更新日期：1986-09-25 00:00:00

  • Two patterns of firing in human neocortical neurons.

    abstract：:Intracellular recordings were made in slices of human neocortex removed for surgical treatment of epilepsy. In response to prolonged suprathreshold current injection, regular spiking neurons (67.5% of sample) responded by repetitive firing throughout the stimulus from all membrane potentials. Bursting neurons (32.5% o...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(90)90860-c

    authors： Foehring RC,Wyler AR

    更新日期：1990-03-14 00:00:00

  • Pitrazepin, a novel GABAA antagonist.

    abstract：:Pitrazepin is a potent new GABA antagonist which differs from bicuculline in its chemical structure and its interaction with both [3H]muscimol and [3H]flunitrazepam binding sites, whereby the potency of pitrazepin in displacing [3H]muscimol exceeds that of bicuculline by at least a factor of 10. In physiological exper...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(84)90244-1

    authors： Gähwiler BH,Maurer R,Wüthrich HJ

    更新日期：1984-04-06 00:00:00

  • Statistical learning is lasting and consistent over time.

    abstract：:Implicit detection of statistical regularities is thought to be a ubiquitous facet of cognition; yet, we know little about statistical learning (SL) over time. A recent study showed that visual SL can be observed at 24 h post stimulus (Kim et al., 2009 [14]). Here we sought to obtain a finer-grained picture of visual ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2012.04.045

    authors： Arciuli J,Simpson IC

    更新日期：2012-05-31 00:00:00

  • Mechanism of methionine-enkephalin modulation of glutamatergic transmission in the rat striatum.

    abstract：:The effect of methionine-enkephalin (Met-Enk) on responses of rat brain neostriatum neurones to microiontophoretic application of glutamate was studied in experiments with extracellular recording of spike activity. Met-Enk administered by microiontophoresis was shown to depress the glutamate-induced responses. In para...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(85)90053-9

    authors： Kuznetsov VI,Godukhin OV

    更新日期：1985-06-12 00:00:00

  • Enhancement of cell viability after treatment with polyunsaturated fatty acids.

    abstract：:Attention-deficit/hyperactivity disorder (ADHD) is highly prevalent in children and adolescents and both environmental and genetic factors play major roles. Polyunsaturated fatty acids (PUFAs) are postulated to contribute to the development of the infant brain and an imbalance in these may increase the risk of ADHD. I...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2013.11.023

    authors： Bartl J,Walitza S,Grünblatt E

    更新日期：2014-01-24 00:00:00

  • Metabolomic analysis to detect urinary molecular changes associated with bipolar depression.

    abstract：:Bipolar disorder (BD) is a debilitating mental disorder with complex clinical manifestations and low diagnostic accuracy. Depressive episodes are most common in the course of BD with high comorbidity and suicide rates, which present greater clinical challenges than mania and hypomania episodes. However, there are no o...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2020.135515

    authors： Ren Y,Chen ZZ,Sun XL,Duan HJ,Tian JS,Wang JY,Yang H

    更新日期：2021-01-18 00:00:00

  • Ca2+ imaging of cricket protocerebrum responses to air current stimulation.

    abstract：:Crickets (Gryllus bimaculatus) use the cercal sensory system at the rear of the abdomen to detect air currents and direct predator avoidance behavior. Sensory information regarding the direction and dynamic properties of air currents is processed within the terminal abdominal ganglion, and conveyed by ascending giant ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2014.10.042

    authors： Ogawa H,Kajita Y

    更新日期：2015-01-01 00:00:00

  • Retinal ganglion cell survival is mediated by cell contact with immature rat astroglia.

    abstract：:The survival of identified retinal ganglion cells (RGGs) in vitro increased when they were plated over subcultured monolayers of astrocytes. Immunofluorescence labelling of these monolayers showed that over 85% of the cells were glial fibrillary acidic protein (GFAP) positive and consisted of large, flat immature astr...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(85)90512-9

    authors： McCaffery CA,Raju TR,Bennett MR

    更新日期：1985-06-24 00:00:00

  • Electroacupuncture alleviates surgery-induced cognitive dysfunction by increasing α7-nAChR expression and inhibiting inflammatory pathway in aged rats.

    abstract：:Postoperative cognitive dysfunction (POCD) is a common disorder of cognitive functions in aged patients following anesthesia and surgery. α7-nicotinic acetylcholine receptors (α7-nAChR) plays a regulatory role in cognitive processes and is involved in cognitive deficits. This study aims to observe the effect of electr...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2017.08.043

    authors： Liu PR,Zhou Y,Zhang Y,Diao S

    更新日期：2017-10-17 00:00:00