Abstract:
:Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors which belong to the nuclear receptor family. We examined whether PPARalpha agonists and resveratrol, a polyphenol contained in grapes, protect the brain against ischemia. To investigate whether resveratrol activates PPARs, we performed a cell-based transfection activity assay using luciferase reporter plasmid. PPARalpha and PPARgamma were activated by resveratrol in primary cortical cultures and vascular endothelial cells. Resveratrol (20 mg/kg, 3 days) reduced infarct volume by 36% at 24 h after middle cerebral artery occlusion in wild-type mice. The PPARalpha agonists fenofibrate (30 mg/kg, 3 days) and Wy-14643 (30 mg/kg, days) exerted similar brain protection. However, resveratrol and fenofibrate failed to protect the brain in PPARalpha knockout mice. The data indicate that PPARalpha agonists protect the brain through PPARalpha.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Inoue H,Jiang XF,Katayama T,Osada S,Umesono K,Namura Sdoi
10.1016/j.neulet.2003.09.001keywords:
subject
Has Abstractpub_date
2003-12-11 00:00:00pages
203-6issue
3eissn
0304-3940issn
1872-7972pii
S0304394003010802journal_volume
352pub_type
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