Abstract:
:Reduction of non-protein-bound iron (NPBI) using iron chelators may attenuate hypoxia-ischemia-induced reperfusion injury of the brain. This study investigated whether administration of low-dose deferoxamine and allopurinol, both having NPBI-chelating properties, reduced hypoxia-ischemia-induced NPBI formation in plasma effluent from the brain and in cerebral cortical tissue. Twenty-one newborn lambs underwent severe hypoxia-ischemia. Upon reperfusion and reoxygenation the lambs received either a placebo (n = 7), or deferoxamine 2.5 mg/kg (n = 7) or allopurinol 20 mg/kg (n = 7). The post-hypoxic-ischemic NPBI levels in plasma were significantly lower after deferoxamine but not after allopurinol as compared to placebo-treated lambs. Cortical NPBI levels in both deferoxamine and allopurinol-treated lambs were significantly lower than NPBI levels in placebo-treated lambs. We conclude that deferoxamine effectively lowers NPBI in plasma effluent from the brain, and that both, deferoxamine and allopurinol, lower NPBI in cortical brain tissue.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Shadid M,Buonocore G,Groenendaal F,Moison R,Ferrali M,Berger HM,van Bel Fdoi
10.1016/s0304-3940(98)00303-6subject
Has Abstractpub_date
1998-05-22 00:00:00pages
5-8issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(98)00303-6journal_volume
248pub_type
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