Abstract:
:Current-voltage (I-V) relationships of glutamate receptors activated by the non-NMDA receptor agonist, kainate (KA), were determined in Xenopus laevis oocytes injected with either calf or chick brain mRNA. In most injected oocytes (n = 44; 84%), I-V plots to 80 microM KA exhibited inward rectification; however, in some oocytes (n = 7; 16%), the KA-evoked membrane current showed only slight outward rectification. A comparison between the resting membrane properties of injected oocytes with the KA-evoked currents revealed that weak outward rectification was often observed in oocytes possessing predominant voltage-activated calcium-dependent chloride currents (ICl(Ca)). In these oocytes, replacement of extracellular calcium (2 mM Ca2+) with magnesium ions (Mg2+), or the addition of the chloride channel blocker, anthracene-9-carboxylic acid (500 microM to 1 mM A9C), reduced ICl(Ca) and also altered the nature of the KA I-V plot revealing inward rectification. It is proposed that the responses mediated by expressed non-NMDA receptors may be influenced by the activation of endogenous calcium-dependent membrane currents in Xenopus laevis oocytes.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Bowie D,Smart TGdoi
10.1016/0304-3940(93)90031-fsubject
Has Abstractpub_date
1993-03-05 00:00:00pages
4-8issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(93)90031-Fjournal_volume
151pub_type
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