Abstract:
:The present study examined effects of high altitude exposure, which leads to development of hypoxia, on epiplexus cells associated with the choroid plexus in adult rats. At 2-5 h following exposure, epiplexus cells expressing inducible nitric oxide synthase (iNOS) were commonly observed. Increased expression of complement type 3 receptors (CR3) and major histocompatibility complex class II (MHC II) antigens was also observed 4-14 days after altitude exposure. It is suggested that the early expression of iNOS in epiplexus cells following an altitude exposure may protect the choroid plexus and ventricles from damage caused by reactive oxygen species during reoxygenation. The enhanced expression of CR3 receptors and MHC II antigens at later time intervals may be involved in protection of cerebral ventricular system from any infection that may accompany or follow altitude exposure.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Wang D,Kaur Cdoi
10.1016/s0304-3940(00)01070-3keywords:
subject
Has Abstractpub_date
2000-05-19 00:00:00pages
197-200issue
3eissn
0304-3940issn
1872-7972pii
S0304394000010703journal_volume
285pub_type
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