Response of epiplexus cells associated with the choroid plexus in the lateral ventricles of adult rats to high altitude exposure.

Abstract:

:The present study examined effects of high altitude exposure, which leads to development of hypoxia, on epiplexus cells associated with the choroid plexus in adult rats. At 2-5 h following exposure, epiplexus cells expressing inducible nitric oxide synthase (iNOS) were commonly observed. Increased expression of complement type 3 receptors (CR3) and major histocompatibility complex class II (MHC II) antigens was also observed 4-14 days after altitude exposure. It is suggested that the early expression of iNOS in epiplexus cells following an altitude exposure may protect the choroid plexus and ventricles from damage caused by reactive oxygen species during reoxygenation. The enhanced expression of CR3 receptors and MHC II antigens at later time intervals may be involved in protection of cerebral ventricular system from any infection that may accompany or follow altitude exposure.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Wang D,Kaur C

doi

10.1016/s0304-3940(00)01070-3

keywords:

subject

Has Abstract

pub_date

2000-05-19 00:00:00

pages

197-200

issue

3

eissn

0304-3940

issn

1872-7972

pii

S0304394000010703

journal_volume

285

pub_type

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